Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02528877
Details
2016-09-14
Interventional
10 
Fludarabine Fludarabine pho… Mechlorethamine Melphalan Nitrogen Mustar… Sirolimus Tacrolimus
Graft vs Host D… Leukemia Leukemia, Myelo… Leukemia, Myelo… Neoplasm Metast… Primary Myelofi… Acute Myeloid L… Primary Myelofi… Secondary Acute… Secondary Myelo…
The study design was revised so a new protocol will be opened.
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NCT01865175
Details
2016-09-14
Interventional
40 
Iron
Iron Deficienci… Iron Deficiency
Institution required IND, although FDA did not, so institution did not allow enrollment
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NCT01077947
Details
2016-09-13
Interventional
40 
Anesthetics
Back Pain Low Back Pain Discogenic Pain
Internal
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NCT01121757
Details
2016-09-12
Interventional
211 
Azacitidine Lenalidomide
Lymphoma Lymphoma, B-Cel… Lymphoma, Folli… Follicular Lymp… Marginal Zone L…
The study closed temporarily in February 2012 pending analysis of samples collected. In October, 2012, Celgene requested closure of the study.
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NCT00190476
Details
2016-09-12
Interventional
3-
Docetaxel
Carcinoma, Non-… Lung Neoplasms Non-small-cell …
-
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NCT02894554
Details
2016-09-09
Interventional
419 
Lamivudine Telbivudine
HBsAg-positive …
clinical myalgia
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NCT02654730
Details
2016-09-09
Interventional
2/361 
Artemisinins Artenimol Piperaquine Primaquine
Malaria
Enrollment took longer than anticipated; it was financially and logistically impossible to recruit the final cohort (G6PDd 0.4mg/kg PQ).
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NCT00922532
Details
2016-09-09
Interventional
30 
Nitric Oxide
Hypertension Hypertension, P… Hypoxia Respiratory Ins… Hypoxic Respira…
Company decision not to pursue prior to submission
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NCT02222207
2012-003763-22
Details
2016-09-08
Interventional
252 
Ranibizumab
Macular Degener… Wet Macular Deg…
-
As the study was prematurely terminated since pre-defined proof of concept (PoC) criteria were not met in Part A, hence part B was not initiated. Part B related end points and data were not reported since it is not conducted.
NCT00973271
Details
2016-09-01
Interventional
30 
Atorvastatin Fenofibrate Fenofibric acid
Hypertriglyceri…
Did not continue with development of DCCR in Very High Triglycerides
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NCT00901823
Details
2016-09-01
Interventional
10 
Choline Diazoxide
Hypertriglyceri…
Did not support the planned development of DCCR in the new indication
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NCT01882387
Details
2016-08-31
Interventional
20 
Angiotensin I (…
Graft vs Host D… Hematologic Neo… Hematologic Mal…
Change in drug product development strategy
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NCT01882374
Details
2016-08-31
Interventional
20 
Angiotensin I (…
Graft vs Host D… Hematologic Neo… Hematologic Mal…
Change in drug product development strategy
-
NCT01584362
Details
2016-08-30
Interventional
1
[3 Refs]
0 
Oxfendazole
Neurocysticerco… Taeniasis Tenia Solium In…
study conducted under Clinical Trials Agreement as NIAID registration NCT02234570
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NCT00676559
Details
2016-08-26
Interventional
10 
Ranibizumab
Edema Macular Edema Diabetic Macula…
Unrelated serious adverse events involving one of the proposed medications
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NCT02876770
Details
2016-08-24
Interventional
112 
Melatonin
Motor Activity
-
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NCT02120274
Details
2016-08-24
Interventional
485 
Hydroxocobalami… Vitamin B 12 Vitamin D Vitamins
Communicable Di… Flaviviridae In… Hepatitis Hepatitis A Hepatitis C Hepatitis C, Ch… Infections RNA Virus Infec… Virus Diseases
New Brazilian Guidelines for Viral Hepatitis C and Coinfetions. It does not include the treatment of chronic HCV Metavir < F3 and abandon the use of interferon.
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NCT02030574
Details
2016-08-24
Interventional
22 
Gemcitabine
Urinary Bladder… Bladder Cancer Invasive Bladde…
The study is being closed to accrual secondary to low accrual and an interest in opening up a different trial.
The study has been terminated secondary to low accrual and an interest in opening up a different trial; more tailored to Physician interests and patient need.
NCT00404703
Details
2016-08-24
Interventional
237 
Bevacizumab
Carcinoma, Non-… Lung Neoplasms Non-Small Cell …
Primary (safety) endpoint reached
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NCT00771056
Details
2016-08-22
Interventional
223 
Hydroxychloroqu…
Leukemia Leukemia, Lymph… Leukemia, Lymph… B-Cell Chronic …
study suspended while data is reviewed for safety and efficacy.
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