Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02142192
2014-000917-30
Details
2016-09-29
Interventional
22 
Natalizumab
Multiple Sclero… Sclerosis Relapsing Multi…
Sponsor's decision.
-
NCT02000375
2012-003510-13
Details
2016-09-29
Interventional
220 
Dehydroepiandro…
Breast Neoplasm… Neoplasms Androgen Recept… Estrogen Recept… Estrogen Recept… Metastatic Brea… Progesterone Re… Progesterone Re…
Due to slow recruitment and recent new published data
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NCT00781326
Details
2016-09-29
Interventional
49 
Nimodipine
Depression Depressive Diso…
Final cost of study medication was significantly greater than initial estimate,
Study was terminated for administrative reasons at the end of Phase I (open label antidepressant treatment). No subjects entered Phase II (Nimodipine vs Placebo).
NCT02172001
Details
2016-09-28
Interventional
30 
Iron isomaltosi…
Anemia Anemia, Iron-De… Deficiency Dise… Iron Deficienci… Iron Deficiency…
Study design not adequate
-
NCT02862145
Details
2016-09-27
Interventional
1/20 
Dexamethasone
Melanoma
5 immune related serious adverse events in Phase 1 study
-
NCT02123498
Details
2016-09-26
Interventional
40 
Omeprazole Pantoprazole Ranitidine Ranitidine bism…
Gastroesophagea… Laryngopharynge… Eustachian Tube…
IRB not approved
-
NCT01724918
Details
2016-09-26
Interventional
272 
Lacosamide
Epilepsies, Par… Epilepsy Focal Epilepsy
Time limitation for recruitment exceeded. 72 of 90 estimated sample recruited.
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NCT00281931
Details
2016-09-26
Interventional
2-
Cyclophosphamid… Fludarabine Fludarabine pho… Rituximab
Leukemia Leukemia, Proly… Prolymphocytic …
-
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NCT02823106
Details
2016-09-23
Interventional
10 
Choline Cytidine Diphos… Verapamil
Ischemia Ischemic Stroke
Study put on clinical hold by FDA. Sponsor decided to no pursue the study.
-
NCT00862706
Details
2016-09-23
Interventional
40 
Telbivudine
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch… Hepatitis, Chro… Compensated Chr…
Stopped with Patients
-
NCT02047747
Details
2016-09-22
Interventional
24 
Dacomitinib
Brain Neoplasms Neoplasm Metast… Brain Cancer
slow enrollment
-
NCT00190554
Details
2016-09-22
Interventional
3-
Cisplatin Fluorouracil
Carcinoma Carcinoma, Squa… Esophageal Neop… Esophageal Squa…
-
-
NCT02573935
2014-002187-32
Details
2016-09-20
Interventional
258 
Clarithromycin
Multiple Myelom… Neoplasms, Plas…
Suspected side effects to the combination of clarithromycin and VCD (bortezomib, cyclophosphamide and dexamethasone)
-
NCT00446602
Details
2016-09-20
Interventional
20 
Epoetin Alfa
Myelodysplastic… Preleukemia Syndrome Anemia
Due to company decision to focus resources on a larger, controlled study in this patient population.
-
NCT00336700
Details
2016-09-19
Interventional
225 
Erlotinib Hydro… Gemcitabine
Pancreatic Neop… Pancreatic Canc…
Study published November 2010 and no further work will be done
-
NCT02903901
Details
2016-09-16
Interventional
40 
Melatonin
Delirium Emergence Delir…
Investigator found that a new study drug that is FDA approved would be superior to melatonin
-
NCT00920153
Details
2016-09-16
Interventional
3442 
Bleomycin Carmustine Cytarabine Dacarbazine Dexamethasone Doxorubicin Etoposide Gemcitabine Ifosfamide Liposomal doxor… Melphalan Methylprednisol… Mitoguazone Vincristine Vindesine Vinorelbine
Hodgkin Disease Lymphoma
Other new drugs
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NCT02780830
Details
2016-09-15
Interventional
10 
Ibrutinib
Lymphoma Lymphoma, B-Cel… Lymphoma, Large… Core: Relapsed … Module 1: Non-G…
Study D2276C00001 was not started. No patients were enrolled. The sponsor decided to pursue an alternate design.
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NCT01986218
Details
2016-09-15
Interventional
136 
BMS-986115
Various Advance…
(Non-safety reason, business objectives have changed)
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NCT00926627
2007-005117-18
Details
2016-09-15
Interventional
232 
Bosentan
Hypertension, P… Sarcoidosis Sarcoidosis, Pu… Pulmonary Hyper…
Not enough patients with the specified criteria could not
-