Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02894515
2016-000405-37
Details
2016-11-11
Interventional
10 
(2-(6-fluoro-1H…
Bioequivalence
The study was withdrawn based on new efficacy data from another study
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NCT00369915
Details
2016-11-10
Interventional
217 
Butylscopolammo… Scopolamine
Bipolar Disorde… Depression Depressive Diso… Bipolar Depress… Unipolar Depres…
-
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NCT01774604
Details
2016-11-04
Interventional
3449 
Indomethacin
Pancreatitis Post-ERCP Acute…
Futility
The study was terminated due to indomethacin's lack of efficacy after 449 patients had been enrolled. Thus the study may be underpowered to draw conclusions about the role of indomethacin in preventing post ERCP pancreatitis
NCT01702714
2012-003376-39
Details
2016-11-04
Interventional
10 
Carboplatin Gemcitabine Paclitaxel
Carcinoma, Non-… Lung Neoplasms Neoplasm Metast… Non-Squamous No…
Project Team decision
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NCT01579864
2011-000370-59
Details
2016-11-03
Interventional
46 
Rocuronium Succinylcholine
Anesthesia
recent publication (Ghezel-Ahmadi. Thorac Cardiovasc Surg. 2014 Nov 21)
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NCT01151943
2010-019662-88
Details
2016-11-03
Interventional
477 
Anesthetics Anesthetics, Lo…
Cesarean Sectio…
The study has been halted prematurely beacuse of the occurence of convulsions in one case after TAP block.
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NCT01114997
Details
2016-11-03
Interventional
432 
Esmolol Lidocaine
Constipation Vomiting Nausea Pain
The early report didn't show any benefit.
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NCT00819169
Details
2016-11-03
Interventional
1/289 
Conatumumab
Colorectal Canc… Locally Advance… Metastatic Canc… Non-Small Cell … Ovarian Cancer Pancreatic Canc… Sarcoma Solid Tumors
Sponsor decision - subjects rolled over to protocol 20101116
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NCT01516476
Details
2016-11-02
Interventional
22 
Liraglutide
Diabetes Mellit… Diabetes Mellit… Diabetes Mellit…
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NCT01423539
Details
2016-11-02
Interventional
20 
Bendamustine Hy… Navitoclax Rituximab
Lymphoma Lymphoma, B-Cel… Lymphoma, Large… Diffuse Large B…
The NAVIGATE study has been terminated due to non-safety related reasons.
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NCT01260194
Details
2016-11-02
Interventional
44 
Trastuzumab
Stomach Neoplas… Gastric Cancer
-
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NCT01179113
Details
2016-11-02
Interventional
433 
Esmolol
Laminectomy
The preliminary result didn't show any benefit.
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NCT01051011
Details
2016-11-02
Interventional
3370 
Glucagon-Like P… Insulin Glargin… Metformin
Diabetes Mellit… Diabetes Mellit… Diabetes Mellit…
high discontinuation rates mainly due to GI tolerability and implementation of risk mitigation plan to address hypersensitivity reactions
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NCT00985374
2008-005806-38
Details
2016-11-02
Interventional
111 
Everolimus
Neoplasms
-
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NCT00845910
Details
2016-11-02
Interventional
222 
Bevacizumab Capecitabine Docetaxel
Breast Neoplasm… Breast Cancer
To be confirmed
-
NCT00811993
Details
2016-11-02
Interventional
1104 
Bevacizumab Capecitabine Carboplatin Cetuximab Docetaxel Erlotinib Hydro… Etoposide Gemcitabine Irinotecan Sorafenib Temozolomide Trastuzumab
Neoplasms
-
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NCT01882075
Details
2016-10-31
Interventional
42 
Hydroxyethyl St…
Anesthesia
Dysfonction of the device
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NCT00427973
Details
2016-10-31
Interventional
2
[1 Refs]
17 
Cediranib
Carcinoma Carcinoma, Hepa… Liver Neoplasms Adult Primary H… Advanced Adult … Localized Unres… Recurrent Adult…
The study was stopped prior to 2nd stage.
Despite reaching the prespecified goal for the first stage of the trial, the study was stopped and did not proceed to the second stage after reviewing the development program of cediranib by AstraZeneca for reasons unrelated to this study.
NCT01701297
2010-022886-92
Details
2016-10-28
Interventional
210 
Trimethoprim, S…
Ascites Fibrosis Liver Cirrhosis Peritonitis Decompensated C…
Unable to obtain QP release certification from the manufacturer (VSL3) for shipment of IMP
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NCT00346749
Details
2016-10-28
Interventional
4-
Fluticasone Salmeterol Xina… Xhance
Lung Diseases Lung Diseases, … Pulmonary Disea…
The study was terminated due to difficulties with finding sites and subjects willing to participate.
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