Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01148966
Details
2017-02-15
Interventional
16 
Aminolevulinic …
Astrocytoma Brain Neoplasms Glioblastoma Glioma Gliosarcoma Oligodendroglio… Adult Anaplasti… Adult Anaplasti… Adult Giant Cel… Adult Glioblast… Adult Gliosarco… Adult Mixed Gli… Recurrent Adult…
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NCT00722436
Details
2017-02-15
Interventional
420 
Tranexamic Acid
Craniosynostose… Bleeding Craniosynostosi…
Study dose changed based on recent publications
Study terminated because two studies published during the trial demonstrated efficacy of tranexamic acid at a lower dose.
NCT00052598
Details
2017-02-15
Interventional
1/27 
Aldesleukin Interleukin-2
Blast Crisis Leukemia Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Myelodysplastic… Preleukemia Recurrence Syndrome Accelerated Pha… Acute Myeloid L… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Blastic Phase C… Childhood Chron… Childhood Myelo… Recurrent Adult… Recurrent Child… Relapsing Chron… Secondary Acute…
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NCT02242409
Details
2017-02-14
Interventional
24 
Albumin-Bound P… Gemcitabine Paclitaxel
Pancreatic Neop… Pancreatic Canc…
Testing of combination no longer relevant
-
NCT02167360
Details
2017-02-14
Interventional
20 
Tisagenlecleuce…
Leukemia Leukemia, Lymph… Precursor Cell … B-cell Acute Ly… Refractory B-ce… Relapsed B-cell…
Did not enroll
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NCT01299701
Details
2017-02-14
Interventional
17 
Vadimezan
Neoplasms Advanced Solid …
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NCT01264341
2010-020664-38
Details
2017-02-14
Interventional
239 
Bevacizumab MTOR Inhibitors Sirolimus Temsirolimus
Kidney Neoplasm… Kidney Cancer
Based on the developments in the treatment of recurrent metastatic renal cancer, the study treatment is no longer considered to be the best treatment option
-
NCT01204333
Details
2017-02-14
Interventional
2/367 
Heparin
Intracranial Th… Sinus Thrombosi… Thrombosis Venous Thrombos…
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NCT01489319
Details
2017-02-10
Interventional
147 
Salicylsalicyli… Sodium Salicyla…
Polycystic Ovar… Syndrome
The PI left Indiana University. The findings served as preliminary data for a recently awarded NIH R01 grant.
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NCT01470651
Details
2017-02-10
Interventional
426 
Modafinil
Hepatitis Hepatitis A Hepatitis C
European Medicines Agency issued a drug/drug interaction: sofosbuvir/modafinil
It is difficult to attribute side effects to Armodafinil or placebo given patients were undergoing Hepatitis C Treatment throughout the trial.
NCT00635024
Details
2017-02-10
Interventional
21 
Antilymphocyte … Melphalan
Multiple Myelom… Neoplasms, Plas… Plasmacytoma Multiple Myelom…
Due to competing trials, this study is permanenlty closed to patient acrrual.
After 1 patient was recruited, this trial temporarily closed to allow the first dose of Anti-thymocyte Globulin to be split over two days. Before the modification was written, it was decided to permanently close this study due to competing trials.
NCT00585221
Details
2017-02-10
Interventional
28 
Imatinib Mesyla… Peginterferon a…
Gastrointestina… Neoplasms Cancer Brain Solid Tumors
PI terminated at the recommendation of DSMC & IRB
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NCT00434993
Details
2017-02-10
Interventional
2/3282 
Albuterol Dimercaprol
Acute Lung Inju… Lung Injury Respiratory Dis… Respiratory Dis… Respiratory Dis…
Stopped for futility by DSMB
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NCT02299271
Details
2017-02-09
Interventional
472 
Ropivacaine
Osteoarthritis,… Pain, Postopera… Osteoarthritis …
Preliminary analysis showed no difference between groups.
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NCT02076893
Details
2017-02-09
Interventional
464 
Gabapentin Ibuprofen Tramadol
Pain
Interim analysis results indicated need to recruit beyond scope of budget.
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NCT03044379
Details
2017-02-08
Interventional
10 
Dapivirine
HIV 1 Infection
Current program is on hold, not for safety reason
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NCT00448682
Details
2017-02-07
Interventional
225 
Docetaxel Floxuridine Leucovorin Levoleucovorin Oxaliplatin
Stomach Neoplas… Gastric Cancer
-
The study was terminated prematurely by the University of Miami Institutional Review Board. The results have not been analyzed.
NCT00133796
Details
2017-02-07
Interventional
240 
Trastuzumab
Breast Neoplasm… BREAST CANCER
Closed to accrual 4/19/2006 / Study doesn't qualify for reporting.
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NCT00082225
Details
2017-02-07
Interventional
14 
Antibodies
Lymphoma
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NCT00087620
Details
2017-02-03
Interventional
4-
Capecitabine
Breast Neoplasm… Breast Cancer
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