Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02512679
Details
2017-02-27
Interventional
2
[1 Refs]
20 
Cyclophosphamid…
Anemia, Diamond… Genetic Disease… Granulomatous D… Immunologic Def… Lymphoprolifera… Metabolic Disea… Thalassemia Wiskott-Aldrich… Allogeneic Tran… Bone Marrow Tra… Chronic Granulo… Combined Immune… Diamond-Blackfa… Genetic Disease… Pediatrics Peripheral Bloo… Stem Cell Trans… X-linked Lympho…
Optimal dose obtained for engraftment and minimizing toxicity
De-escalation was not ensued. All enrolled subjects engrafted without toxicity for dose level one.
NCT01989091
Details
2017-02-27
Interventional
3270 
Heparin
Dialysis Cathet…
Did not meet predetermined primary endpoint
-
NCT01601704
Details
2017-02-27
Interventional
38910 
Bupropion hydro…
Overweight Obesity
-
The study was terminated early. Outcome measures data is based on the 50% interim analysis, designated as the primary analysis. Safety data is based on all available data at the time of database lock, which occurred after the 50% interim analysis.
NCT01967199
Details
2017-02-24
Interventional
4175 
Everolimus Paclitaxel
Coronary Resten…
-
-
NCT01899690
Details
2017-02-24
Interventional
40 
Anti-Bacterial … Cephalexin Clindamycin
Communicable Di… Infections Inflammation Complications; …
The study was withdrawn prior to IRB approval.
-
NCT00171938
Details
2017-02-24
Interventional
230 
Imatinib Mesyla…
Glioblastoma
-
-
NCT01493505
Details
2017-02-23
Interventional
31015 
Carboplatin Paclitaxel Trebananib
Carcinoma, Ovar… Fallopian Tube … Ovarian Neoplas… Fallopian Tube … Ovarian Cancer Peritoneal Canc…
Amgen Administrative Decision - termination of LTFU
-
NCT00841945
Details
2017-02-23
Interventional
3334 
Doxorubicin Prednisone Rituximab Vincristine
Lymphoma B Cell Lymphoma
other drugs other studies
-
NCT00637780
Details
2017-02-23
Interventional
42 
Sulfasalazine
Arthritis Arthritis, Juve… Arthritis, Juve…
Study terminated on 13 April 2016 for business reasons. No safety and/or efficacy concerns contributed to the termination of the study
The study was terminated prematurely and only 2 participants were enrolled and completed the study.
NCT00470535
Details
2017-02-23
Interventional
218 
Erlotinib Hydro…
Pancreatic Neop… Pancreatic Canc…
This study was terminated earlier due to a phase III study that showed this drug inferior to sorafenib
This study was terminated earlier due to a phase III study that showed this drug was not better than sorafenib
NCT00240981
Details
2017-02-23
Interventional
4
[1 Refs]
209 
Testosterone
Hypogonadism Muscular Diseas… Sarcopenia
Higher incidence of cardiovascular events in the testosterone arm of the trial. Decision taken by the DSMB on December 31st, 2009.
-
NCT02723981
Details
2017-02-20
Interventional
40 
Anticoagulants Clopidogrel Dabigatran Rivaroxaban Vitamin K Vitamins
Angina Pectoris Angina, Stable Angina, Unstabl… Coronary Diseas… NSTEMI STEMI Stable Angina Unstable Angina
Regulatory authority approval for the initial study design could not be obtained
-
NCT01621477
Details
2017-02-20
Interventional
234 
Antilymphocyte … Busulfan Clofarabine Cyclophosphamid… Cytarabine Mycophenolic Ac… Plerixafor Tacrolimus Thymoglobulin
Hematologic Neo… Leukemia Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Myelodysplastic… Neoplasms Precursor Cell … Sarcoma, Myeloi… Acute Lymphobla… Acute Myelocyti… Chronic Myelocy… Hodgkin or Non-… Juvenile Myelom… Myelodysplastic…
Study was terminated in August 2016 due to replacement by a new study.
-
NCT01574248
Details
2017-02-17
Interventional
433 
Icatibant
Angioedema ACE Inhibitor-a…
DSMC recommended discontinuation for futility and feasibility
-
NCT01338857
Details
2017-02-17
Interventional
212 
Sorafenib
Astrocytoma Glioma Neurofibroma Neurofibromatos… Neurofibromatos… Recurrence Recurrent or Pr… Recurrent or Pr… neurofibromatos…
Sorafenib ineffective for tx of recurrent or progressive PLGA
-
NCT01179594
2009-017602-36
Details
2017-02-17
Interventional
40 
Entecavir Interferon-alph… Peginterferon a…
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch…
This study was canceled for operational reasons.
-
NCT00250692
Details
2017-02-17
Interventional
30 
Nitrous Oxide
Analgesic Affec…
unknown - no record of study conduct in departmental archive
-
NCT02254551
Details
2017-02-16
Interventional
27 
Bortezomib
Multiple Myelom… Neoplasms, Plas…
Safety lead-in data did not support continuation of study.
Early termination of study during dose-escalation did not support continuation of study.
NCT02716090
Details
2017-02-15
Interventional
30 
Adapalene Benzoyl Peroxid…
Acne Vulgaris
Due to budget limitations, the company decided to withdraw this study.
-
NCT01838642
Details
2017-02-15
Interventional
23 
Ponatinib
Thyroid Disease… Thyroid Neoplas…
Recruiting halted prematurely and will not resume. New study to open soon.
-