Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02231164
Details
2017-03-21
Interventional
312 
Docetaxel Nintedanib
Carcinoma, Non-…
-
The sponsor cancelled this trial prematurely. Thus, enrollment for 1199.128 was significantly less than what was planned (800 planned vs. 12 entered). Therefore, the objectives of this study could not be fully assessed.
NCT01845025
2012-004854-27
Details
2017-03-21
Interventional
4827 
Fluticasone Formoterol Fuma… Xhance
Asthma Persistent Asth…
Due to the action to withdraw the Foradil Aerolizer NDA in US; study was discontinued. This was a commercial reason and not due to any change in benefit-risk.
-
NCT00907166
Details
2017-03-21
Interventional
1/26 
Gemcitabine
Carcinoma Pancreatic Neop… Cancer Pancreatic Canc… Pancreatic Carc…
Suspended trial was not restarted.
-
NCT00745823
Details
2017-03-21
Interventional
3775 
Emtricitabine, … Raltegravir Pot…
HIV
Primary efficacy analysis at Week 48 did not demonstrate non-inferiority of raltegravir 800 mg once daily versus raltegravir 400 mg twice daily
The study was terminated before the 96-week efficacy analysis. Adverse event data were collected for the entire treatment period up to a maximum of Week 108, which defines the Overall Study period.
NCT00496366
Details
2017-03-21
Interventional
211 
Capecitabine Lapatinib
Breast Neoplasm… Advanced Breast… Breast Cancer HER2/Neu-positi… Metastatic Brea…
-
-
NCT00464763
Details
2017-03-21
Interventional
30 
Dexmedetomidine
Delirium
The incidence of post-operative delirium observed from interim blinded data in DEX-06-09 was significantly lower than the current literature in this population.
-
NCT00443729
Details
2017-03-21
Interventional
3355 
Lopinavir Raltegravir Pot… Ritonavir
HIV Infections HIV Infection
Primary efficacy analysis at Week 24 did not demonstrate non-inferiority of raltegravir versus lopinavir (+) ritonavir
Study was terminated after the primary efficacy analysis at Week 24 did not demonstrate non-inferiority of MK0518 versus KALETRA™.
NCT00443703
Details
2017-03-21
Interventional
3352 
Lopinavir Raltegravir Pot… Ritonavir
HIV Infections HIV Infection
primary efficacy analysis at Week 24 did not demonstrate non-inferiority of raltegravir versus lopinavir (+) ritonavir
The reason for early termination: Study was terminated after the primary efficacy analysis at Week 24 did not demonstrate non-inferiority of MK0518 versus KALETRA™.
NCT02670317
2015-005273-20
Details
2017-03-20
Interventional
21 
Cyclophosphamid… Doxorubicin Ibrutinib Obinutuzumab Prednisone Vincristine
Lymphoma Lymphoma, B-Cel…
GA101-CHOP not advantage from rituximab-CHOP
-
NCT01207765
Details
2017-03-20
Interventional
28 
Antibodies, Mon…
Multiple Myelom… Neoplasms, Plas…
changes in practice
Study ended at end of stage 1
NCT02676310
Details
2017-03-17
Interventional
153 
Bimatoprost
Alopecia Alopecia Areata Alopecia, Andro… Baldness
-
-
NCT01504659
Details
2017-03-16
Interventional
2/35 
Ketamine
Bipolar Disorde…
Administrative issues
-
NCT01145326
Details
2017-03-16
Interventional
2/30 
Lidocaine
Pain Perception Phlebotomy
The device is undergoing further study in China, per FDA requirements.
-
NCT01943188
Details
2017-03-15
Interventional
12 
Cyclophosphamid…
Carcinoma Carcinoma, Rena… Clear Cell Rena… Recurrent Renal… Stage IV Renal …
-
-
NCT01155791
Details
2017-03-15
Interventional
12 
Docetaxel Prednisone
Neoplasm Metast… Prostatic Neopl… Urologic Neopla… Prostate Cancer Prostate Cancer…
-
-
NCT01089595
Details
2017-03-15
Interventional
25 
Imatinib Mesyla… Nilotinib
Neoplasm Metast… GIST Metastatic Dise…
Novartis is ending their research program for Nilotinib in GIST.
Trial ended early due to industry support of provision of nilotinib was discontinued.
NCT00571194
Details
2017-03-15
Interventional
17 
Pravastatin
Kidney Failure,… End Stage Renal…
-
-
NCT00263211
Details
2017-03-15
Interventional
248 
Aspirin Clopidogrel
Breast Neoplasm…
Stopped due to low percentage of patients with detectable CTCs at baseline.
Inclusion of patients with no or few CTC's limited ability to distinguish anti-platelet therapeutic effect. Early termination because of low probability of reaching statistical significance for primary outcome
NCT01357655
2011-000083-10
Details
2017-03-14
Interventional
270 
Dasatinib
Leukemia
No participants enrolled in this trial could receive the SMO antagonist as a recommended phase 2 dose was not determined by a different, concurrently-run trial.
No recommended phase 2 dose of the SMO antagonist was determined (in a separate trial). It was decided to discontinue enrollment and end this trial early. The decision was not made due to any new safety signals for dasatinib or the SMO antagonist.
NCT00692003
2007-003557-91
Details
2017-03-14
Interventional
321 
Zonisamide
Seizures Epilepsy
Sponsor's decision
This study was terminated early at the Sponsor's discretion. When this study was discontinued, only 6 subjects had been treated. Data from the 5 subjects treated with zonisamide were insufficient to draw firm conclusions regarding efficacy.