Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04915950
Details
2023-12-22
Interventional
213 
APD791
Neoplasm Metast… Raynaud Disease Scleroderma, Di… Scleroderma, Sy… Sclerosis Raynaud's Pheno…
Business decision
This study was terminated early due to a business decision that was not due to any safety concerns. The number of participants was smaller than originally planned and only summary statistics were therefore generated for primary and secondary outcome measures.
NCT04450316
Details
2023-12-22
Interventional
2-
Naltrexone
Cystitis Cystitis, Inter… Somatoform Diso… Syndrome Bladder Pain Sy… Interstitial Cy…
Study temporarily suspended awaiting research personnel to resume recruitment
-
NCT05932667
Details
2023-12-21
Interventional
21 
Fulvestrant
Breast Neoplasm… Advanced or Met…
Financial partner providing study drug could no longer support the trial
-
NCT04425629
2020-003690-21
Details
2023-12-21
Interventional
310078 
Casirivimab and…
COVID-19
Emerging SARS-CoV-2 variants impacting susceptibility to study drug
Nasal and saliva sample collection was discontinued early in the study because nasopharyngeal samples were determined to be more reliable for quantitative analysis, as such endpoints related to nasal or saliva samples were not analyzed. The Phase 1/2 SAP does not specify any analyses related to nasal and saliva samples collections
NCT04267939
2018-003930-34
Details
2023-12-21
Interventional
114 
Niraparib
Carcinoma, Ovar… Ovarian Neoplas… Advanced Solid … Ovarian Cancer
There was no anticipated benefit of the experimental combination as tested over available standard therapies; therefore Sponsor has decided to terminate the investigation.
-
NCT03640481
Details
2023-12-21
Interventional
2159 
Belumosudil
Bronchiolitis O… Graft vs Host D… Chronic Graft-v…
The sponsor has decided to prematurely terminate the study due to the challenges encountered in recruiting adolescent participants. This decision was made without any safety concerns.
-
NCT00579969
Details
2023-12-21
Interventional
230 
Latanoprost Timolol
Glaucoma
Study stopped and data not analyzed
-
NCT03954041
2018-003858-24
Details
2023-12-20
Interventional
292 
Glyburide
Brain Contusion Contusions
Early completed due to strategic considerations, not for efficacy or safety reasons.
Early termination of trial due to strategic considerations, not for efficacy or safety reasons.
NCT02603146
Details
2023-12-20
Interventional
2144 
Hydroxychloroqu…
Arthritis Arthritis, Rheu… Healthy Partici… Rheumatoid Arth…
Enrollment was closed before reaching the target. In the 1st interim analysis after enrollment closure, the follow up & treatment of active participants were stopped early due to evidence of futility.
Enrollment closed at 144 randomized participants before reaching the target of 200 due to slow participant accrual. The decision was supported by a revised power analysis suggesting sufficient power for the study with reduced numbers assuming a clinically-relevant difference in RA rates between arms (50% risk for placebo & 25% risk for HCQ). In the 1st interim analysis after enrollment closure, the follow up & treatment of the active participants were stopped early due to evidence of futility.
NCT04714619
Details
2023-12-19
Interventional
22 
Anastrozole Letrozole
Breast Neoplasm… Advanced Breast…
Sponsor decision
-
NCT04151563
2018-004283-65
Details
2023-12-19
Interventional
1/20 
Docetaxel Ipilimumab Nivolumab Ramucirumab
Carcinoma, Non-… Lung Neoplasms Carcinoma, Non-…
Business objectives have changed
-
NCT03871829
2018-004185-34
Details
2023-12-19
Interventional
288 
BB 1101 Dexamethasone Dexamethasone a…
Multiple Myelom… Neoplasms, Plas…
The decision was made to discontinue the 54767414MMY2065 study as the Data Review Committee recommendation was early stop of the study for futility.
-
NCT02531854
Details
2023-12-19
Interventional
20 
Pemetrexed
Carcinoma Carcinoma, Non-…
Study was withdrawn per sponsor decision
-
NCT02153437
Details
2023-12-19
Interventional
17 
Sotalol
Atrial Fibrilla…
-
-
NCT05687110
Details
2023-12-18
Interventional
1-
Novobiocin
Neoplasms Metastatic Mali… Unresectable Ma…
Other - FDA Clinical Hold
-
NCT05330884
Details
2023-12-18
Interventional
3-
BCG Vaccine
Latent Tubercul… Tuberculosis Tuberculosis In…
changes in protocol
-
NCT04515329
Details
2023-12-18
Interventional
40 
Cyclosporine Cyclosporins Lubricant Eye D…
Dry Eye Syndrom… Keratoconjuncti… Dry Eye
No participants were enrolled. Study never started.
-
NCT04506554
Details
2023-12-18
Interventional
2-
Nivolumab
Urinary Bladder… Muscle-Invasive…
Slot availability
-
NCT04359017
Details
2023-12-18
Interventional
40 
Lidocaine
Hematoma Radius Fracture… Lidocaine Pediatrics Radius Fracture…
Sponsoring staff have left institution
-
NCT03794583
Details
2023-12-18
Interventional
341 
Treprostinil
Hypertension Hypertension, P… Lung Diseases Lung Diseases, … Pulmonary Disea… Chronic Obstruc… Pulmonary Hyper…
Sponsor's decision
Per sponsor decision, the study was terminated early.