Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02801799
Details
2017-03-30
Interventional
160 
Ropivacaine
Pain, Postopera… Anaesthesia Other Acute Pos…
The trial was comprised of two parts. After the first part we could repudiate our hypothesis. Thus, no reason to carry on with the second part of the trial.
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NCT01351792
2010-022895-30
Details
2017-03-30
Interventional
3113 
Budesonide, For…
Lung Diseases Lung Diseases, … Pulmonary Disea… Chronic Obstruc…
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NCT01206101
2009-013090-18
Details
2017-03-30
Interventional
23 
Liraglutide
Diabetes Mellit… Diabetes Mellit… Diabetes
The decision to close the NN2211-3619 trial was based on the very low recruitment rate as well as challenges relating to trial execution and study completion.
Due to the premature termination of the trial prior to islet cell transplantation in any randomised subject, no results are available.
NCT00738699
Details
2017-03-30
Interventional
2415 
Albumin-Bound P… Farletuzumab Paclitaxel
Carcinoma, Ovar… Ovarian Neoplas… Ovarian Cancer
study did not meet pre-specified criteria for continuation following interim futility analysis
This study was prematurely terminated by the sponsor following results of the preplanned futility analysis showing the study was unlikely to meet its statistically-defined coprimary endpoints.
NCT02087241
Details
2017-03-29
Interventional
222 
Adavosertib Carboplatin Pemetrexed
Carcinoma, Non-… Lung Neoplasms Previously Untr…
The sponsor decided to terminate the study.
The study was terminated on June 1, 2015 by the sponsor. The Primary Outcome Measure (Progression Free Survival) was not assessed and the randomised portion of the study was not done.
NCT02015663
Details
2017-03-29
Interventional
432 
Tobramycin
Cystic Fibrosis Fibrosis
-
Due to premature termination, summaries and analyses planned in the protocol were eliminated in the statistical analysis plan prior to database lock. No inferential analysis will be provided.
NCT01475266
Details
2017-03-29
Interventional
2/351 
Apaziquone
Urinary Bladder… Bladder Cancer
Sponsor's decision
-
NCT00807612
Details
2017-03-29
Interventional
1/249 
Antibodies, Mon… Carboplatin Paclitaxel
Carcinoma, Non-… Lung Neoplasms Advanced Squamo…
Study was closed due to administrative decision
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NCT01940536
Details
2017-03-28
Interventional
40 
Tranexamic Acid
Fractures, Bone Hemorrhage Hip Fractures Blood Loss Hip Fracture
Possible change in study protocol
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NCT01589861
Details
2017-03-28
Interventional
1/2-
Lapatinib
Breast Neoplasm… Breast Cancer
Data analysis
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NCT00553735
Details
2017-03-28
Interventional
48 
Cyclosporine Cyclosporins Lubricant Eye D…
Dry Eye Syndrom… Graft vs Host D… Keratoconjuncti… Dry Eye
High number of withdrawals, appt. no-shows, or those lost to follow-up.
The study was terminated early due to a high number of patients who withdrew themselves, failed to show for their appointments, or were lost to follow-up.
NCT00526643
2005-005631-97
Details
2017-03-28
Interventional
3
[1 Refs]
57 
Gemcitabine
Carcinoma, Non-… Lung Neoplasms Non-Small Cell …
scarce enrolment and presentation of positive results of similar study in June 2012.
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NCT00208403
Details
2017-03-28
Interventional
436 
Polymethyl Meth…
Necrosis Avascular Necro… Osteoarthritis Post-traumatic …
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NCT00863512
Details
2017-03-27
Interventional
334 
Docetaxel Gemcitabine Pemetrexed Vinorelbine
Carcinoma, Non-… Lung Neoplasms Lung Cancer
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NCT02721511
Details
2017-03-24
Interventional
1/20 
Furosemide
Heart Failure Acute Decompens…
Investigator decision based on new device information.
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NCT01118013
Details
2017-03-24
Interventional
26 
Antilymphocyte … Busulfan Fludarabine Fludarabine pho… Methotrexate Mycophenolic Ac… Tacrolimus
Leukemia Lymphoma Lymphoprolifera… Multiple Myelom… Myelodysplastic… Myelodysplastic… Myeloproliferat… Neoplasms Neoplasms, Plas… Plasmacytoma Preleukemia Syndrome Lymphoprolifera… Multiple Myelom… Myelodysplastic…
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NCT00711698
Details
2017-03-24
Interventional
20 
Analgesics, Opi…
Anemia, Sickle … Sickle Cell Dis… Vaso-occlusive …
technical difficulties coordinating study
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NCT01564095
Details
2017-03-23
Interventional
2/3
[1 Refs]
25 
Pharmaceutical … Tacrolimus Tryptophan
Ischemia Liver Diseases Reperfusion Inj… Wounds and Inju… Graft Dysfuncti… Graft Failure Ischemia Reperf… Poor Graft Qual… Terminal Liver …
Missing evidence of the effectiveness of the study medication
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NCT00609765
Details
2017-03-23
Interventional
21 
Bevacizumab Dexamethasone Doxorubicin Fluorouracil Ondansetron Streptozocin
Endocrine Gland… Pancreatic Canc…
Development of new chemotherapy standard of care for treatment rendered the trial obsolete.
This trial only enrolled one patient and was closed because of development of a new chemotherapy standard of care for treatment of this cancer which we felt rendered the trial obsolete. The trial was open for only 7 months.
NCT00176488
Details
2017-03-23
Interventional
231 
Epirubicin Vinorelbine
Breast Neoplasm… Breast Cancer
Competing studies
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