Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

Filter:

Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
Free Text
Annotations

7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02011347
2012-003001-97
Details
2017-04-06
Interventional
367 
Ketamine
Anesthesia
-
-
NCT01611675
Details
2017-04-06
Interventional
13 
Leflunomide Vemurafenib
Melanoma
Adverse Events
-
NCT01480232
Details
2017-04-06
Interventional
2345 
Nicotine
Tobacco Use Dis… Nicotine Depend… Smoking Cessati…
Study has been put on clinical hold by FDA
-
NCT01424033
Details
2017-04-06
Interventional
2/35 
Acetylcysteine N-monoacetylcys…
Connective Tiss… Lung Diseases Lung Diseases, … Connective Tiss… Interstitial Lu…
Departure of study team
Five subjects were consented. Study was terminated prior to conclusion due to departure of PI.
NCT00687544
Details
2017-04-06
Interventional
411 
Peginterferon a… Ribavirin
Hepatitis Hepatitis A Hepatitis C Hepatitis C, Ch… Infections HIV Infections Hepacivirus
-
The study was terminated early due to low enrollment. The primary and secondary outcomes were not evaluated. A formal safety analysis was not performed for the 11 participants enrolled in the study.
NCT02527174
Details
2017-04-05
Interventional
10 
Cytarabine Idarubicin
Leukemia Leukemia, Eryth… Leukemia, Megak… Leukemia, Monoc… Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo…
Volasertib no longer available
-
NCT02382523
Details
2017-04-05
Interventional
40 
Adrenocorticotr…
Glomerulonephri… Kidney Diseases Proteinuria IgA Nephropathy
There were no subjects enrolled locally on this study since it opened. Local IRB closure has been requested.
-
NCT02321384
2014-002297-36
Details
2017-04-05
Interventional
1100 
Midazolam Ritonavir
Healthy Volunte…
-
-
NCT02210949
Details
2017-04-05
Interventional
47 
Epoetin Alfa
Anemia, Iron-De… Iron Deficienci… Heart; Dysfunct…
Low inclusion rate
-
NCT02058303
Details
2017-04-05
Interventional
490 
Bupivacaine
Finger Injuries Hand Injuries Wounds and Inju… Wrist Injuries
PI leaving instutition
-
NCT00588900
Details
2017-04-05
Interventional
25 
Cediranib Irinotecan
Colorectal Neop… Colorectal Canc…
-
-
NCT00360776
NCT00331591
Details
2017-04-05
Interventional
225 
Tipifarnib
Leukemia Leukemia, Large… Leukemia, Lymph… Leukemia, Lymph… Stage III Chron… Stage IV Chroni… T-cell Large Gr…
-
-
NCT02159040
Details
2017-04-04
Interventional
21 
Azacitidine Deferasirox
Myelodysplastic… Preleukemia High Risk MDS
-
No conclusion pertaining to efficacy and/or safety was drawn, only one patient was randomized to the study and their study participation was terminated prematurely due to fatal outcome of SAE.Only one patient in trial.No analysis will ever be done.
NCT01923623
Details
2017-04-04
Interventional
40 
Ropivacaine
Ankle Fractures Fractures, Bone Ankle Fracture …
Study was redesigned and taken over by a ph.D-student
-
NCT01364259
Details
2017-04-04
Interventional
317 
Amifostine
Neuralgia Trigeminal Neur…
Patterns of practice changed and this technique is no longer used.
-
NCT01173848
Details
2017-04-04
Interventional
319 
Cholecalciferol Ergocalciferols Vitamin D
Kidney Diseases Renal Insuffici… Chronic Kidney …
-
Adverse Events were not logged by study arms. Early termination of the study lead to small numbers of subjects analyzed.
NCT01607645
Details
2017-03-31
Interventional
27 
Azacitidine Cytarabine Decitabine Idarubicin
Anemia, Refract… Anemia, Refract… Leukemia Leukemia, Eryth… Leukemia, Megak… Leukemia, Monoc… Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Myelodysplastic… Adult Acute Meg… Adult Acute Mon… Adult Acute Mon… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Erythrole… Adult Pure Eryt… Previously Trea… Recurrent Adult… Refractory Anem…
The study was terminated early because there were other competing protocols.
Early termination due to similar competing protocol, which made statistical evaluation of primary endpoint and any meaningful evaluation of secondary time points not feasible.
NCT01090128
Details
2017-03-31
Interventional
127 
Albumin-Bound P… Cyclophosphamid… Doxorubicin Paclitaxel
Breast Neoplasm… Stages II-III B…
Drug Manufacturer withdrew support for studies not in metastatic breast cancer
-
NCT00761228
Details
2017-03-31
Interventional
2-
Apomorphine
Brain Injuries Brain Injuries,… Persistent Vege… Wounds and Inju… Brain Injury
-
-
NCT00698685
NCT00543283
Details
2017-03-31
Interventional
214 
Alemtuzumab Pentostatin
Carcinoma, Rena… Hematologic Neo… Hodgkin Disease Leukemia Multiple Myelom… Hodgkin's Disea… Lymphoma
Pentostatin/alemtuzumab regimen had greater risk of graft failure.
We did not meet criteria to stop the study because of nonrelapse mortality (safety endpoint). However, we stopped accrual to the study because of failure to meet minimal criteria for engraftment (efficacy endpoint).