Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03026803
Details
2017-04-13
Interventional
24 
Capecitabine Oxaliplatin
Carcinoma, Hepa… Liver Neoplasms Hepatocellular … Liver Cancer
Due to Sorafenib became first line treatment for HCC, the designed treatment became less competitive. The company Sanofi decided not to continue to support
Due to Sorafenib becoming a first line treatment for HCC, the designed treatment became less competitive. The company Sanofi decided not to continue support. Study was terminated after accrual of 4 of the 32 planned patients.
NCT02387242
Details
2017-04-13
Interventional
1-
Rifampin
Tuberculosis
New relevant data published
-
NCT01037335
Details
2017-04-13
Interventional
40 
Morphine
Autogenous Bone…
No participants enrolled
-
NCT03110952
Details
2017-04-12
Interventional
10 
Vaccines alpha-Tocophero…
Dengue
lack of materials, not moving forward
-
NCT02145676
2013-002346-37
Details
2017-04-12
Interventional
353 
Botulinum Toxin… Botulinum Toxin… abobotulinumtox…
Muscle Spastici… Stroke
-
-
NCT01754376
Details
2017-04-12
Interventional
26 
Aldesleukin Interleukin-2 Vemurafenib
Melanoma
changes in available treatments for melanoma
The protocol terminated early due to a dramatic change in the treatment landscape for treating BRAF mutant melanoma (e.g. one BRAF/MEK inhibitor combination and two anti-PD1 antibodies were approved by the FDA while this study was open).
NCT00833053
2008-000454-12
Details
2017-04-12
Interventional
339 
Infliximab Methotrexate
Psoriasis
In Amendment 1 of P05319 [NCT 00779675], the option to enroll into this study, was discontinued due to low numbers of participants with suboptimal response.
-
NCT00537316
Details
2017-04-12
Interventional
3
[1 Refs]
242 
Azathioprine Infliximab
Colitis Colitis, Ulcera… Ulcer Ulcerative Coli…
Infusion reactions during re-induction cycles after a period of no treatment in another study [P04563, NCT0358670]
-
NCT01153919
Details
2017-04-11
Interventional
227 
Interferon alph… Interferon-alph… Interferons Peginterferon a… Ribavirin
Hepatitis Hepatitis A Hepatitis C Thrombocytopeni… Hepatitis C Inf…
Approval of several new agents for the treatment of HCV infection would mitigate the future need for interferon HCV treatment
-
NCT01151449
Details
2017-04-11
Interventional
26 
2,2-dimethyl-N-…
Breast Neoplasm… Breast Neoplasm… Recurrence Triple Negative… Estrogen Recept… HER2-negative B… Male Breast Can… Progesterone Re… Recurrent Breas… Stage IIIA Brea… Stage IIIB Brea… Stage IIIC Brea… Stage IV Breast… Triple-negative…
Administratively Complete
-
NCT00358670
2005-005367-28
Details
2017-04-11
Interventional
3
[1 Refs]
441 
Infliximab
Psoriasis
Infusion reactions during re-induction cycles after a period of no treatment. Please see "Purpose" section.
-
NCT02044302
Details
2017-04-10
Interventional
22 
Analgesics Botulinum Toxin… Bupivacaine Morphine Narcotics
Pain, Postopera… Post-operative …
-
-
NCT01140399
Details
2017-04-10
Interventional
410 
Dopamine Furosemide
Cardio-Renal Sy… Heart Failure Acute Decompens…
insufficient enrollment
-
NCT00126451
Details
2017-04-10
Interventional
216 
Vorinostat
Carcinoma, Non-… Breast Cancer Colorectal Canc… Non-small-cell …
-
-
NCT02413827
Details
2017-04-07
Interventional
1/29 
Antibodies, Mon… Ipilimumab Poly ICLC
Melanoma Unresectable St…
Feasibility concerns due to changes in standard of care
-
NCT02200380
Details
2017-04-07
Interventional
236 
Plerixafor
Hodgkin Disease Leukemia Leukemia, Lymph… Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Lymphoma, Non-H… Myelodysplastic… Precursor Cell … Preleukemia Acute Lymphobla… Acute Myelogeno… Chronic Lymphoc… Chronic Myeloge… For Donors For Recipients Hodgkins Diseas… Myelodysplastic… Non-Hodgkins Ly… Related Donors …
-
-
NCT02071641
Details
2017-04-07
Interventional
25 
Sunitinib
Carcinoma Carcinoma, Rena… Metastatic Rena…
-
-
NCT01195727
Details
2017-04-07
Interventional
113 
Apixaban
Thromboembolism Venous Thromboe…
-
-
NCT02571283
Details
2017-04-06
Interventional
40 
Bupivacaine Epinephrine
Pain Management Total Knee Arth…
PI decided to focus on more current topics of interest.
-
NCT02227108
Details
2017-04-06
Interventional
237 
Immunotoxin HA2…
Leukemia Leukemia, Lymph… Lymphoma Precursor Cell … B-Cell Pediatri…
The study was terminated prior to a planned interim analysis based on lack of required efficacy in the first 32 participants enrolled.
The study was terminated prior to a planned interim analysis based on lack of required efficacy in the first 32 participants enrolled.