Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03035357
Details
2017-04-21
Interventional
20 
Daratumumab
Genital Neoplas… Neoplasms Prostatic Neopl… Malignant Neopl… Prostate Cancer
PI's Request
-
NCT02319265
Details
2017-04-21
Interventional
1/20 
Melatonin
Sepsis Toxemia
Study registered elsewhere and is not covered by FDA
-
NCT00708799
Details
2017-04-21
Interventional
2-
Azithromycin
Sepsis Systemic Inflam…
Safety evaluation due to recent publications.
-
NCT00397501
Details
2017-04-21
Interventional
1/20 
Carboplatin Methotrexate Sodium thiosulf… Trastuzumab
Breast Neoplasm… Central Nervous… Drug-Related Si… Nervous System … Brain and Centr… Breast Cancer Cognitive/Funct… Drug/Agent Toxi… Psychosocial Ef…
after original approval, IRB closed enrollment; major revisions required to re-open.
-
NCT00346151
Details
2017-04-21
Interventional
25 
Abatacept Antilymphocyte … Glucocorticoids Immunoglobulins Methylprednisol… Sirolimus Thymoglobulin
Renal Transplan…
Stopping rule-acute rejection threshold-was met based on local biopsy results
The trial was stopped early due to meeting an acute rejection threshold of three acute rejections based on local pathology reads in the first five participants enrolled.
NCT00238173
Details
2017-04-21
Interventional
12 
Acetylcysteine Carboplatin Cyclophosphamid… Etoposide Etoposide phosp… Mannitol N-monoacetylcys… Sodium thiosulf…
Brain Neoplasms Central Nervous… Drug-Related Si… Nervous System … Bone Marrow Sup… Brain and Centr… Drug/Agent Toxi… Long-term Effec…
OHSU IRB closed study to further enrollment 2/17/2006
-
NCT02520102
Details
2017-04-20
Interventional
20 
Sargramostim
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
Company has fulfilled post-marketing requirements
-
NCT01977339
Details
2017-04-20
Interventional
40 
Bupivacaine
Total Knee Arth…
New departmental administration, loss of key study faculty
-
NCT01715311
2012-001536-59
Details
2017-04-20
Interventional
40 
Tiotropium Brom…
Lung Diseases Lung Diseases, … Pulmonary Disea… Chronic Obstruc…
withdrawn prior to patient recruitment
-
NCT00978146
Details
2017-04-20
Interventional
20 
Hydroxyurea
Fibroma Fibromatosis, A… Desmoid Tumors Fibromatosis
Study was administratively withdrawn by the IRB; no subjects were enrolled
-
NCT00955474
Details
2017-04-20
Interventional
432 
Citalopram Escitalopram Quetiapine Fuma… Sertraline
Depression Depressive Diso… Depressive Diso… Mental Disorder… Psychotic Disor… Major Depressiv…
AstraZeneca halted funding; patent expired for Seroquel (Quetiapine) in 2012
-
NCT01758458
Details
2017-04-19
Interventional
1/24 
Aldesleukin Interferon-beta Interferons Interleukin-2
Carcinoma Carcinoma, Merk… Recurrent Merke… Stage IV Merkel…
A Phase I/II study (NCT01758458) is now recruiting
-
NCT00886743
Details
2017-04-19
Interventional
219 
Oprelvekin
Thrombocytopeni… Severe Thromboc…
Business reason, Pfizer's requested withdrawal of the Biologics License Application (BLA) . This study is not being discontinued for efficacy or safety reason
-
NCT03117855
Details
2017-04-18
Interventional
10 
Capecitabine
Carcinoma, Duct… Cholangiocarcin… Bile Duct Adeno… Stage III Intra… Stage IVA Intra… Stage IVB Intra…
Company no longer interested in supporting this trial
-
NCT01750762
Details
2017-04-18
Interventional
11 
Lenalidomide
Multiple Myelom… Lymphoma
-
-
NCT00879970
Details
2017-04-18
Interventional
41332 
Pioglitazone Rosiglitazone Vitamin D
Diabetes Mellit…
FDA has placed the trial on full clinical hold.
The intended duration of this study was approximately 5.5 years. However, the trial was stopped prematurely because of regulatory concerns after a mean of 162 days without consideration of the accrued data.
NCT02721277
Details
2017-04-17
Interventional
1/22 
SMOFlipid
Cholestasis Jaundice Jaundice, Obstr…
-
-
NCT01409993
Details
2017-04-17
Interventional
478 
Sildenafil Citr…
Glucose Intoler… Impaired Glucos…
Aim 1 was stopped by DSMB. Aim 2 was stopped due to ending of funding.
-
NCT01267240
Details
2017-04-14
Interventional
225 
Capecitabine Vorinostat
Carcinoma Carcinoma, Squa… Recurrence Squamous Cell C… Paranasal Sinus… Recurrent Hypop… Recurrent Laryn… Recurrent Oral … Recurrent Oroph… Stage IVA Hypop… Stage IVA Laryn… Stage IVA Oral … Stage IVA Oroph… Stage IVB Hypop… Stage IVB Laryn… Stage IVB Oral … Stage IVB Oroph… Stage IVC Hypop… Stage IVC Laryn… Stage IVC Oral … Stage IVC Oroph…
Study treatment did not show clinical activity.
Early termination due to lack of activity of study drug.
NCT00642616
Details
2017-04-14
Interventional
334 
Insulin
Asthma Diabetes Mellit… Diabetes Mellit… Diabetes Mellit… Lung Diseases Lung Diseases, … Pulmonary Disea… Moderate Chroni… Type 1 Diabetes… Type 2 Diabetes…
Terminated upon recommendation of the Data Safety Monitoring Board (DSMB)
- Early termination of trial leading to small numbers of subjects analyzed