Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01437943
Details
2017-05-01
Interventional
410 
Aliskiren
Kidney Diseases Kidney Failure,… Renal Insuffici… Kidney Disease
Novartis has have decided to terminate all clinical investigator-initiated research projects involving aliskiren
In December 2011, all studies involving Aliskiren were terminated by Novartis after interim analysis of the ALTITUDE trial.
NCT00827281
Details
2017-05-01
Interventional
20 
Cycloserine
Smokers
Study was not funded and pilot work proved impractical.
-
NCT02840162
Details
2017-04-28
Interventional
234 
Celecoxib
Prostatic Neopl… Adenocarcinoma … Prostate Cancer
Drug safety concerns
-
NCT02371577
Details
2017-04-28
Interventional
20 
Lenalidomide
Leukemia, Lymph… Chronic Lymphoc…
withdrawn
-
NCT01913015
Details
2017-04-28
Interventional
13 
Abiraterone Ace…
Prostatic Neopl… Adenocarcinoma … Hormone-resista… Recurrent Prost… Stage IV Prosta…
After enrollment of the first 3 subjects, an interim assessment was conducted. Comparing DBS sampling to plasma PK levels yielded unconvincing results.
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NCT00796419
Details
2017-04-28
Interventional
331 
Hydroxyethyl St…
Acute Lung Inju… Lung Injury Respiratory Dis… Respiratory Dis… Wounds and Inju… Lung Injury, Ac… Respiratory Dis…
-
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NCT00459810
Details
2017-04-28
Interventional
221 
Estradiol Paclitaxel Paclitaxel poli…
Prostatic Neopl… Prostate Cancer
-
-
NCT02511613
Details
2017-04-27
Interventional
20 
Ophthalmic Solu… Pharmaceutical … Ranibizumab Squalamine
Macular Degener… Age-Related Mac…
Company decision
-
NCT02447016
Details
2017-04-27
Interventional
425 
Efavirenz Emtricitabine Rilpivirine Tenofovir
HIV
no more participants taking atripla
-
NCT02060669
Details
2017-04-27
Interventional
310 
Capecitabine
Colorectal Neop… Metastatic Colo…
others
-
NCT00239720
Details
2017-04-27
Interventional
24 
Muromonab-CD3
Arthritis Arthritis, Psor…
Study team decision-impact(s) of change in hOKT3γ1 (Ala-Ala) manufacturer during study.
This study was put on voluntary clinical hold after a serious adverse event occurred. After a review of the data, the team decided to close the study to further enrollment. Due to limited participants, no formal statistical analyses were performed
NCT03065933
Details
2017-04-26
Interventional
45 
Clonidine
Bipolar Disorde… Bipolar Disorde…
-
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NCT02430532
2014-003021-18
Details
2017-04-26
Interventional
358 
Dimethyl Fumara…
Multiple Sclero… Multiple Sclero… Neoplasm Metast… Sclerosis Multiple Sclero…
Sponsor Decision
The study was terminated early by the sponsor for business reasons. Efficacy, patient-reported outcomes, and pharmacodynamic data were not analyzed.
NCT01171482
Details
2017-04-26
Interventional
25 
Fluorouracil Mitomycin Mitomycins Sorafenib
Carcinoma Carcinoma, Hepa…
There were problems with national reimbursement policies.
-
NCT00062972
Details
2017-04-25
Interventional
30 
Donepezil
Multiple Sclero… Sclerosis
Study terminated/withdrawn
-
NCT02567396
Details
2017-04-24
Interventional
10 
Talazoparib
Breast Neoplasm… Carcinoma Carcinoma, Non-… Carcinoma, Ovar… Lung Neoplasms Mesothelioma Mesothelioma, M… Ovarian Neoplas… Small Cell Lung… Squamous Cell C… Stomach Neoplas… Estrogen Recept… HER2/Neu Negati… Head and Neck S… Hormone-Resista… Metastatic Panc… Progesterone Re… Solid Neoplasm Stage III Mesot… Stage IIIA Gast… Stage IIIA Non-… Stage IIIA Ovar… Stage IIIA Smal… Stage IIIB Gast… Stage IIIB Non-… Stage IIIB Ovar… Stage IIIB Smal… Stage IIIC Gast… Stage IIIC Ovar… Stage IV Mesoth… Stage IV Non-Sm… Stage IV Ovaria… Stage IV Small … Triple-Negative…
Other- Protocol moved to Disapproved
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NCT02542098
Details
2017-04-24
Interventional
20 
Hydrocodone
Pain
Study has been updated with a new protocol number
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NCT01520025
Details
2017-04-24
Interventional
418 
Fluorodeoxygluc…
Ischemia Myocardial Isch…
Continued recruitment of study participants was not feasible
-
NCT01236508
Details
2017-04-24
Interventional
4-
Fluorodeoxygluc…
Carotid Stenosi… Inflammation Leukoencephalop… Stroke Carotid Artery … TIA
difficulties recruiting this population for study population
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NCT00937417
Details
2017-04-24
Interventional
10 
Docetaxel
Breast Neoplasm… Head and Neck N… Lung Neoplasms Prostatic Neopl… Breast Cancer Head and Neck C… Lung Cancer Prostate Cancer Unspecified Adu…
Withdrawn because SWOG no longer pursuing this study at this time
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