Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01349192
Details
2017-05-15
Interventional
247 
Chlorhexidine Chlorhexidine g… Minocycline Mupirocin Rifampin Sulfamethoxazol… Trimethoprim
Cystic Fibrosis Fibrosis Staphylococcal … Methicillin-res…
Interim review showed a statistically significant treatment effect and the DMC recommended that the study be stopped with ongoing follow-up of enrolled subjects
The study was completed prior to reaching the pre-specified number of participants as the Data Safety Monitoring committee observed that efficacy had been reached.
NCT00863434
Details
2017-05-15
Interventional
22 
Clofarabine Cytarabine
Leukemia Leukemia, Myelo… Leukemia, Myelo… Neoplasm, Resid… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Recurrent Adult…
-
-
NCT00706914
Details
2017-05-15
Interventional
2156 
Formoterol Fuma…
Lung Diseases Pulmonary Disea…
Actual sample size of 156 was sufficient to estimate the clinical outcomes.
Due to early termination of the study, the actual sample size is different from the study design (200 patients) Actual sample size was 156, but because this was an exploratory study, this was considered sufficient to estimate the clinical outcomes
NCT00082017
NCT00085319
Details
2017-05-15
Interventional
220 
7-hydroxystauro…
Lymphoma Lymphoma, Large… Lymphoma, T-Cel… Lymphoma, T-Cel… Lymphoma, Large…
IND was withdrawn by CTEP due to low accrual and cost of maintaining the IND.
-
NCT01746940
Details
2017-05-12
Interventional
3159 
Cocaine Pharmaceutical …
Diagnostic Procedures and … of the Nasal Ca…
Trial operational issues.
-
NCT01641939
2012-000660-22
Details
2017-05-12
Interventional
2/3415 
Ado-Trastuzumab… Maytansine Taxane Trastuzumab
Stomach Neoplas… Gastric Cancer
-
The study was terminated by the Sponsor as the primary analysis results did not meet the primary endpoint.
NCT02088450
Details
2017-05-11
Interventional
24695 
Nitrendipine
Hypertension Isolated Systol… Systolic Murmur…
-
-
NCT01587963
Details
2017-05-11
Interventional
211 
Ascorbic Acid
Critical Illnes… Shock
PI's add. responsibilities and time commitment prevent him from completing trial
Early termination leading to small number of subjects analyzed
NCT01464788
Details
2017-05-11
Interventional
290 
Argatroban Tissue Plasmino…
Ischemic Stroke Stroke
The study was halted prematurely at 90 of 105 planned patients due to the beneficial results of embolectomy clinical trials.
Study limitations include the open-label design that was necessary due to prohibitive costs of placebo manufacture and sham aPTT tests. Given that vessel imaging was not mandatory, a meaningful analysis of early recanalization rates was not possible.
NCT01417104
NCT01123629
Details
2017-05-11
Interventional
2/371 
Aliskiren
Atherosclerosis
Safety concerns with approved medication identified in an unrelated trial
-
NCT01349114
Details
2017-05-11
Interventional
421 
Aliskiren
Hypertension Prehypertension Diabetes Pre-hypertensio…
Sponsor requested termination.
Early termination leading to smaller number of subjects analyzed then anticipated, no adverse effects within the aliskiren group
NCT00449163
Details
2017-05-11
Interventional
2
[1 Refs]
25 
Bevacizumab Floxuridine Irinotecan Leucovorin Levoleucovorin
Colorectal Neop… Colorectal Canc…
Study terminated by University of Miami Institutional Review Board
A total of 25 subjects were enrolled however; data were analyzed for 22 subjects only. Study was terminated early by the University of Miami Institutional Review Board.
NCT03009799
Details
2017-05-10
Interventional
20 
Carboxymethylce…
Conjunctivitis Adenoviral Conj…
Study stopped following management decision
-
NCT00936520
Details
2017-05-10
Interventional
130 
Lifitegrast
Macular Edema Diabetic Macula… Pars Plana Vitr…
Preliminary analysis showed little or no bioactivity.
-
NCT03117166
Details
2017-05-09
Interventional
1/219 
Lidocaine
Pain
multidisciplinary participation could not be overcome.
-
NCT02289495
Details
2017-05-09
Interventional
124 
GSK-2838232 Ritonavir
Acquired Immuno… HIV Infections Infection, Huma…
-
-
NCT01610999
Details
2017-05-09
Interventional
17 
Plerixafor
Leukemia, Lymph… Multiple Myelom… Chronic Lymphoc… Lymphoma
Unavailability of study article
-
NCT01483274
Details
2017-05-09
Interventional
10 
Vaccines
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myelogeno…
Adult patient population barriers.
-
NCT01248858
Details
2017-05-09
Interventional
169 
Trametinib
Cancer
The reason for termination was lack of tolerability and efficacy of the combination treatment
-
NCT01031953
NCT00939302
Details
2017-05-09
Interventional
1/234 
Aprepitant Fosaprepitant
Nausea Vomiting Breakthrough Na… Unspecified Adu…
Drug contract timelines and inadequate enrollment
Missing data did affect results for the 24 hour mark Lack of control group to measure possible neurokinin-1 antagonist (NK1a) inhibition