Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01913483
Details
2017-05-30
Interventional
3732 
Bivalirudin Calcium heparin Heparin
Bleeding Peripheral Endo…
-
-
NCT00808899
Details
2017-05-30
Interventional
24 
Cyclophosphamid… Doxorubicin Etoposide Irinotecan Isotretinoin Temsirolimus Topotecan Tretinoin
Neuroblastoma
Voluntarily closed and terminated by the PI due to lack of feasibility
NB2008 was closed because of the publication of a new standard of care for treating high-risk neuroblastoma.At the time of closure, NB2008 had enrolled only 4 patients, which was an insufficient number of patients to answer the primary objective.
NCT00242879
Details
2017-05-30
Interventional
2130 
Ritonavir
Acquired Immuno… Communicable Di… HIV Infections Infections HIV-1 Infection Infection, Huma…
-
-
NCT00104429
Details
2017-05-30
Interventional
2-
Aplaviroc Lamivudine, zid…
Acquired Immuno… Communicable Di… HIV Infections Infections HIV Infection Infection, Huma…
-
-
NCT00102778
Details
2017-05-30
Interventional
2-
Aplaviroc Lopinavir Ritonavir
Acquired Immuno… Communicable Di… HIV Infections Infections HIV Infection Infection, Huma…
-
-
NCT00088881
Details
2017-05-25
Interventional
262 
Cyclophosphamid… Doxorubicin Liposomal doxor… Prednisone Rituximab Vincristine
Lymphoma Lymphoma, B-Cel… Lymphoma, B-Cel… Lymphoma, Large… Lymphoma, Non-H… Waldenstrom Mac… Contiguous Stag… Extranodal Marg… Nodal Marginal … Noncontiguous S… Splenic Margina… Stage I Adult D… Testicular Lymp… Waldenström Ma…
-
-
NCT01843738
NCT02042040
Details
2017-05-24
Interventional
10 
Vemurafenib
Melanoma BRAFV600 Mutati… Stage IV Melano…
Competing Trials
-
NCT01674413
Details
2017-05-24
Interventional
30 
Adalimumab
Crohn Disease Crohn's Disease
Unable to recruit; all patients interested simply wanted to stop medication
-
NCT00450983
Details
2017-05-24
Interventional
21 
Fludarabine Fludarabine pho… Methotrexate Muromonab-CD3 Thiotepa
Graft vs Host D… Leukemia Myelodysplastic… Preleukemia Syndrome Graft Versus Ho…
-
-
NCT00832624
Details
2017-05-23
Interventional
410 
Sitagliptin Pho…
Diabetes Mellit… Diabetes Mellit… Diabetes Mellit…
Business Reasons
The planned 18-week study was terminated early due to reconsideration of the study design. None of the 10 patients progressed beyond the second study visit, no laboratory tests were performed, and adverse experience data were not collected.
NCT02047019
2012-004493-26
Details
2017-05-22
Interventional
30 
Candesartan Candesartan cil… Nifedipine
Essential Hyper… Hypertension
GPDC decided to terminate the study
-
NCT01757574
Details
2017-05-18
Interventional
40 
Alemtuzumab
Polyradiculoneu… Polyradiculoneu… Chronic Inflamm…
At the request of the global principal investigator, no subjects were enrolled in this study at any site.
-
NCT02200328
Details
2017-05-17
Interventional
476 
Metronidazole
Clostridium Inf… Diarrhea Clostridium Dif…
Patients noncompliant with instructions and follow ups could not be completed.
Early termination: Many patients did not comply with the protocol instructions. Lack of resources to conduct the study. Many patients did not respond to follow up calls.
NCT01542372
Details
2017-05-17
Interventional
4114 
Prazosin
Stress Disorder… Stress Disorder… Posttraumatic S…
Inadequate flow of patients
Owing to lack of recruitment sites the study was ended early. In addition, many more patients than anticipated had no PTSD after Step I and hence could not be randomized to participate in Step II. This greatly impacted on flow.
NCT00947791
Details
2017-05-17
Interventional
41 
Ketamine Midazolam
Bipolar Disorde… Depression
Change in available resources for study procedures
-
NCT00599053
Details
2017-05-17
Interventional
1/27 
Azithromycin
Birth Weight Communicable Di… Infections Respiratory Tra… Ureaplasma Infe… Bacteria Infect…
Enrollment was terminated early due to a change in practice on the obstetrical side that included administering azithromycin to women with preterm labor.
Early termination due to small number enrolled.
NCT03153072
Details
2017-05-15
Interventional
20 
Amiodarone
Tachycardia Tachycardia, Su… Tachycardia, Ve… Supraventricula…
decision of the investigator
-
NCT02289482
Details
2017-05-15
Interventional
120 
GSK-2838232 Ritonavir
Acquired Immuno… HIV Infections Infection, Huma…
Study prematurely terminated due to safety concerns leading to clinical hold
-
NCT02202304
Details
2017-05-15
Interventional
40 
Chlorhexidine Chlorhexidine g… Thymol
Periodontal Dis… Caries Periodontal Dis…
Researcher changed jobs. Unable to carry out the project
-
NCT01355302
2011-000774-58
Details
2017-05-15
Interventional
1/27 
Capecitabine
Stomach Neoplas… Advanced or Met… Previously Untr…
Sites not recruiting
The study was terminated prior to enrollment in Phase 2.