Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02205333
Details
2017-06-28
Interventional
1/248 
Durvalumab Rituximab Tremelimumab
Aggression Lymphoma Lymphoma, B-Cel… Advanced Solid … Aggressive B-ce…
The study was terminated early at the sponsor's discretion.
The study was terminated early at the Sponsor's discretion.
NCT00331058
Details
2017-06-28
Interventional
158 
Prednisolone
Asthma
The study was truncated due to the long period of enrollment and the collection of a sufficient amount of data that allowed the scientific objectives to be met
-
NCT02925533
Details
2017-06-27
Interventional
11 
Pembrolizumab
Carcinoma, Tran… Urinary Bladder… Bladder Cancer
Terminated due to safety concerns.
-
NCT02521077
Details
2017-06-27
Interventional
20 
Ascorbic Acid
Fatigue
Manufacturer unwilling to provide information needed for IND application.
-
NCT01756586
Details
2017-06-27
Interventional
44 
Bupivacaine Dexamethasone
Analgesia Durat…
no logistical support to carry out the study fairly
-
NCT01257802
Details
2017-06-27
Interventional
314 
Leuprolide
Collagen Diseas… Lung Diseases Lung Diseases, … Lupus Erythemat… Rheumatic Disea… Scleroderma, Sy… Systemic Vascul… Vasculitis Isolated Angiit… Lung Disease In… Lung Disease Wi…
-
-
NCT00636935
Details
2017-06-27
Interventional
40 
Anti-Bacterial … Antibiotics, An… Atovaquone Clindamycin Clindamycin pal… Clindamycin pho… Dapsone Pentamidine Prednisone Primaquine Trimethoprim Trimethoprim, S…
Pneumonia Pneumonia, Pneu… Pneumocystis Ca…
No patient completed protocol
-
NCT01868503
Details
2017-06-26
Interventional
27 
Lapatinib
Breast Neoplasm… Breast Neoplasm… Recurrence Male Breast Can… Recurrent Breas… Stage IIIA Brea… Stage IIIB Brea… Stage IIIC Brea…
Protocol modification
-
NCT01163253
2010-020002-15
Details
2017-06-26
Interventional
32867 
Tofacitinib
Psoriasis
-
-
NCT00375752
2004-004007-37
Details
2017-06-26
Interventional
4168 
Letrozole
Breast Neoplasm…
-
Study terminated after 178 patients screened and 168 randomized, due to insufficient recruitment rate (no safety issues decided the reason to terminate study). LPLV for study was on 13-DEC-2010. LPLV of the 5-year follow-up period was on 03-FEB-2016.
NCT02161354
Details
2017-06-23
Interventional
252 
Buprenorphine Naloxone
Toothache Dental Pain
safety and efficacy after cohort 5 did not warrant further dose escalation
-
NCT01851720
Details
2017-06-22
Interventional
2/31 
Fentanyl
Headache Hemorrhage Subarachnoid He… Headaches Assoc…
Inclusion criteria were too strict and therefore we were not able to recruit more patients.
-
NCT01263574
Details
2017-06-22
Interventional
20 
Ethanol
Catheter-Relate… Communicable Di… Infections Short Bowel Syn… Syndrome Catheter Relate…
No participants. IND denied by FDA.
-
NCT00958022
Details
2017-06-22
Interventional
17 
Carboplatin Etoposide Etoposide phosp… Panobinostat Podophyllotoxin
Lung Neoplasms Small Cell Lung… Small Cell Lung…
Based on the tolerabilty challenges of the combination
-
NCT01943565
Details
2017-06-19
Interventional
429 
Hydromorphone
Healthy Pain Pregnancy
Research question answered by another group of researchers (Sviggum et al)
-
NCT00836875
2008-005275-10
Details
2017-06-16
Interventional
331 
Voriconazole
Aspergillosis Invasive Asperg…
This protocol terminated prematurely on July 8, 2013 due to slow enrollment, not because of any safety issues or concerns.
The study was prematurely terminated due to slow enrollment. The study was not terminated due to any safety issues or concerns. Interpretation of the data are limited due to the small sample size and descriptive design.
NCT02410005
Details
2017-06-15
Interventional
2/356 
Calcitriol Dihydroxycholec… Losartan
Diabetic Nephro…
Logistic challenges
-
NCT02030314
Details
2017-06-15
Interventional
40 
Chlorthalidone
Hypertension Resistant Hyper…
The patient population changed. Unable to find patients that meet study criteria
-
NCT02698228
Details
2017-06-14
Interventional
40 
Bupivacaine Morphine
Leg Injuries Wounds and Inju… Fracture Lower Limb Inju…
Study did not occur
-
NCT02619812
Details
2017-06-14
Interventional
24 
Antibodies Colesevelam Hyd… Immunoglobulins Immunoglobulins…
Diarrhea Multiple Myelom… Neoplasms, Plas…
Difficulty recruiting; pill burden and nausea were barriers
This study was terminated early due to difficulty recruiting subjects; pill burden and nausea were barriers to study continuation for subjects accrued. Data were not collected.