Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02368951
Details
2017-07-12
Interventional
120 
Aprutumab ixado…
Medical Oncolog…
-
-
NCT02099604
Details
2017-07-12
Interventional
30 
Interferon alph… Interferon-alph… Interferons Peginterferon a… Ribavirin Vitamin D
Hepatitis Hepatitis A Hepatitis C Hepatitis C, Ch… Hepatitis, Chro… Chronic Hepatit…
Study objectives were considered as obsolete regarding the new AAD arrival
-
NCT01526837
Details
2017-07-12
Interventional
11 
Bevacizumab
Glioblastoma Recurrence Glioblastoma Mu…
Investigators decision
-
NCT01266291
Details
2017-07-12
Interventional
41 
Vigabatrin
Seizures Tuberous Sclero… Complex Partial…
Was not possible to enroll sufficient number of subjects to draw any worthwhile conclusions from the study.
The study was terminated due to insufficient enrollment; 98 potentially eligible patients were pre-screened and only one enrolled. The study was not terminated due to concerns regarding safety or efficacy.
NCT00849875
Details
2017-07-12
Interventional
248 
Dacarbazine Imidazole
Melanoma
Early end of trial notification after termination of long term follow up due to lack of scientific justification to continue collect information.
-
NCT03042013
2016-003183-39
Details
2017-07-11
Interventional
20 
Naquotinib
Subjects With N…
Following recommendation by SOLAR Study IDMC, Astellas closed enrollment in ASP8273 studies.
-
NCT02639819
Details
2017-07-11
Interventional
10 
Aminocaproic Ac…
Cerebral Hemorr… Hemorrhage Intracerebral H…
Study was withdrawn from IRB review on 03/08/16
-
NCT00194792
Details
2017-07-11
Interventional
228 
Capecitabine Exemestane Methotrexate Paclitaxel Triptorelin Pam… Vinorelbine
Breast Neoplasm… Estrogen Recept… HER2-negative B… Progesterone Re… Stage I Breast … Stage II Breast… Stage IIIA Brea…
-
-
NCT03211052
Details
2017-07-07
Interventional
216 
Leuprolide
Prostatic Neopl… Prostate Cancer
IMP no longer available
-
NCT01712646
Details
2017-07-07
Interventional
1/218 
Oxytocin
Psychotic Disor… Schizophrenia Schizophrenia, … Childhood Onset…
-
-
NCT01332552
Details
2017-07-07
Interventional
127 
Ritonavir
Hepatitis Hepatitis A Hepatitis C
Terminated due to unfavorable human pharmacokinetic properties
-
NCT00064987
Details
2017-07-07
Interventional
219 
Follicle Stimul… Hormones
Hypogonadism Kallmann Syndro…
Recruitment was at a standstill. We are currently preparing our results for publication.
-
NCT00981903
Details
2017-07-06
Interventional
2131 
Dalteparin Heparin, Low-Mo… Tinzaparin
Thromboembolism Venous Thromboe… Cancer
Tinzaparin will no longer be available in the United States
-
NCT03208361
2012-003511-63
Details
2017-07-05
Interventional
343 
Amoxicillin Penicillin V Penicillins
Pneumonia Community-acqui…
Lack of financial support to continue with the study recruitment. Independent study financially supported by a national grant with a 4.5 years duration.
-
NCT01147601
Details
2017-07-05
Interventional
16 
Timolol
Hemangioma Hemangioma, Cap… Port-Wine Stain Infant
-
-
NCT03181880
Details
2017-07-02
Interventional
40 
Bromides Formoterol Fuma…
Lung Diseases Lung Diseases, … Pulmonary Disea… Chronic Obstruc…
Study stopped early as AZ have re-prioritised to focus on research to help bring existing and innovative medicines to more patients with asthma and COPD.
-
NCT02432664
Details
2017-07-02
Interventional
185 
Midazolam
Healthy
The study was terminated after the second cohort had completed Part II due complex PK results. There were no safety concerns.
-
NCT01342887
Details
2017-07-02
Interventional
1/26 
Cyclosporine Cyclosporins Etoposide Etoposide phosp… Mitoxantrone Pravastatin
Leukemia Leukemia, Eryth… Leukemia, Megak… Leukemia, Monoc… Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Adult Acute Meg… Adult Acute Min… Adult Acute Mon… Adult Acute Mon… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Erythrole… Adult Pure Eryt… Recurrent Adult…
-
-
NCT00925132
Details
2017-07-02
Interventional
1/239 
Decitabine Panobinostat Temozolomide
Melanoma Metastatic Mela…
Change in the number of approved drugs for metastatic melanoma
This study was closed to enrollment early as there was a change in the number of approved drugs for metastatic melanoma, making Temozolomide as a chemotherapy agent, an unlikely treatment for metastatic melanoma.
NCT00085410
Details
2017-07-02
Interventional
2
[1 Refs]
20 
Bortezomib
Adenocarcinoma Bile Duct Neopl… Cholangiocarcin… Gallbladder Neo… Gastrointestina… Liver Neoplasms Recurrence Adenocarcinoma … Adenocarcinoma … Advanced Adult … Gastrointestina… Localized Unres… Recurrent Adult… Recurrent Extra… Recurrent Gallb… Unresectable Ex… Unresectable Ga…
The trial was discontinued early due to no confirmed partial responses.
The trial was discontinued early due to no confirmed partial responses.