Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

Filter:

Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
Free Text
Annotations

7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01675050
Details
2017-08-30
Interventional
24 
Cyproheptadine
Abdominal Pain Functional Abdo…
Due to the wide availability of the drug in clinical practice, it was impossible to recruit adequate numbers for scientific power.
Statistical analyses were not conducted due to small sample size. Results should be interpreted with extreme caution.
NCT01565148
Details
2017-08-30
Interventional
2185 
Ranibizumab
Edema Macular Edema Diabetic Macula…
Patient's disease progressed and Vision Dropped which led to exit from the study
-
NCT01170364
Details
2017-08-30
Interventional
414 
Sibutramine
Obesity
Terminated due to sibutramine being withdrawn from the market.
Early termination of the study given the withdrawal of sibutramine from the US market.
NCT02421029
Details
2017-08-29
Interventional
40 
Calcium Calcium, Dietar… Edetic Acid Pentetic Acid
Heavy Metal Poi… Heavy Metal Tox…
it was logistically difficult to obtain the drug needed to conduct the study
-
NCT02212210
Details
2017-08-29
Interventional
1135 
Methylprednisol… Methylprednisol… Methylprednisol… Prednisolone Prednisolone ac… Prednisolone he… Prednisolone ph…
Labor Pain Complication of… Fever
PI permanently closed accrual for the study based on FDA warning issued in April 2014. Study is closed
-
NCT01386255
Details
2017-08-29
Interventional
40 
Baclofen
Cerebral Palsy GERD
No participants were enrolled
-
NCT01502761
Details
2017-08-28
Interventional
1/24 
Magnesium Sulfa…
Stroke Acute Stroke
No safety issues. Low enrollment secondary to negative stroke studies 2013
The trial was terminated early (with enrollment only in the first arm) by the investigators due to low enrollment (given results of relevant studies at the time) . There were no safety concerns with the trial or the agent.
NCT01375374
2010-022534-84
Details
2017-08-28
Interventional
311 
Lacosamide Levetiracetam
Epilepsies, Par… Epilepsy, Parti…
Slow progress despite recruitment boosting efforts e.g., expert advice obtained from leading study center Investigators; decision thus made to terminate.
The results of this study are limited due to the small sample size.
NCT00803309
Details
2017-08-28
Interventional
4
[1 Refs]
99 
Interferon alph… Interferon-alph… Interferons Peginterferon a… Ribavirin
Hepatitis Hepatitis C Hepatitis C, Ch…
At the end of the planned recruitment period the expected number of subjects could not be included in the trial.
-
NCT00485472
2006-005048-97
Details
2017-08-28
Interventional
2194 
Lacosamide
Osteoarthritis Osteoarthritis,…
Based on the outcome of the planned first interim analysis, it was decided not to continue the trial. No safety concerns were identified.
-
NCT03013387
Details
2017-08-25
Interventional
20 
Edotreotide Octreotide
Medulloblastoma Meningioma Neuroblastoma Neuroendrocrine…
This project has undergone a significant amount of updates and has been resubmitted under IRB# 201708778
-
NCT00089414
Details
2017-08-25
Interventional
25 
Drospirenone Drospirenone an… Estradiol Ethinyl Estradi… Progesterone
Depression Premenstrual Dy… Premenstrual Sy… PMDD PMS
Informed by manufacturer that CDB-2914 crosses blood-brain barrier invalidating Arm #3 of protocol.
Protocol terminated after receiving information from manufacturer (Pharma) that CDB-2914 crosses the blood-brain barrier, invalidating Arm #3 due to potential CNS effect of the compound on behavior.
NCT03191981
Details
2017-08-24
Interventional
1/20 
Cyclophosphamid… Lenalidomide Pembrolizumab
Multiple Myelom… Neoplasms, Plas… Myeloma Multipl…
Withdrawal of pharma support prior to opening to recruitment
-
NCT02345746
Details
2017-08-24
Interventional
20 
Fluorouracil Folic Acid Leucovorin Levoleucovorin Oxaliplatin
Colorectal Neop… Metastatic Colo…
patient population
-
NCT02049151
2013-003760-30
Details
2017-08-23
Interventional
335 
Cyclophosphamid…
Carcinoma, Non-…
The study is terminated prematurely as the sponsor decided to discontinue program with Tecemotide in NSCLC
Sponsor discontinued development of tecemotide (L-BLP25) in NSCLC, hence the study was terminated.
NCT01668017
Details
2017-08-23
Interventional
126 
Niacinamide
Carcinoma, Hepa… Advanced Solid … Hepatocellular …
The sponsor decided not to conduct the expansion part of trial (part 2)
Due to the Sponsor's decision not to pursue the study drug as monotherapy, the Expansion Phase (Part 2) of the study was not conducted.
NCT01508104
Details
2017-08-23
Interventional
119 
Dactolisib Everolimus
Cancer
funding
-
NCT02902744
Details
2017-08-22
Interventional
40 
Fluocinolone Ac…
Edema Macular Edema Diabetic Macula…
The study was withdrawn due to difficult recruitment of patients for the study; No participants were enrolled in the study.
-
NCT02810886
Details
2017-08-22
Interventional
20 
Gallium 68 PSMA…
Prostatic Neopl… Recurrence Prostate Cancer…
Recent publications demonstrating the clinical interest in performing 68Ga-PSMA for recurrence detection of prostate cancer patients with biochemical relapse
-
NCT01662115
Details
2017-08-22
Interventional
44 
Nicotine
Ileus Post-operative …
Study has been terminated due linability to recruit the targeted participants. Aimed for 300 participants and only 4 were enrolled after 1 year.
Principal Investigator decided for an early termination of the enrollment period due to small numbers of subjects consented, with limited data to make conclusions.