Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01013701
Details
2017-09-13
Interventional
47 
Fluticasone Xhance
Nasal Polyps Patients With N…
Terminated based on mutual agreement between PI and sponsor (Glaxo Smith Kline)
-
NCT02586961
2015-002477-38
Details
2017-09-12
Interventional
2/3195 
Betamethasone Betamethasone V… Betamethasone b… Betamethasone s… Betamethasone-1… Epinephrine Epinephryl bora… Racepinephrine
Bronchiolitis Emergencies Children
Removal of Adrénaline lots for safety reasons.
-
NCT01960153
Details
2017-09-12
Interventional
30 
Tadalafil
Heart Failure Hypertension Hypertension, P… Pulmonary Hyper…
Award was ended by NIH for parent study
-
NCT01538901
Details
2017-09-12
Interventional
410 
Imiquimod
Keratosis Keratosis, Acti… Actinic Keratos…
prolonged recruitment phase
-
NCT02876081
Details
2017-09-11
Interventional
20 
Afatinib
Adenocarcinoma Small Cell Lung… SMALL CELL LUNG…
medical decision
-
NCT02222727
2013-002457-30
Details
2017-09-11
Interventional
219 
Donepezil
Brain Ischemia Cerebral Infarc… Hemorrhage Subarachnoid He… Aneurysmal Suba… Delayed Cerebra… Delayed Neurolo… Vasospasm
CT scanner software incompatible
-
NCT01894022
Details
2017-09-11
Interventional
319 
Ambrisentan
Hypertension Hypertension, P…
-
-
NCT01517984
Details
2017-09-11
Interventional
2
[1 Refs]
52 
Antilymphocyte … Calcineurin Inh… Immunosuppressi… Mycophenolic Ac… Prednisone Tacrolimus Thymoglobulin
Kidney Transpla…
Absence of equipoise on the basis of predetermined stopping rules.
After meeting protocol stopping rules, this trial was closed to new enrollment and randomization. No additional prespecified withdrawal of tacrolimus was allowed. Those already enrolled or randomized were followed for up to 24 months post-transplant.
NCT01416181
2010-021978-11
Details
2017-09-11
Interventional
3889 
Natalizumab
Multiple Sclero… Multiple Sclero… Neoplasm Metast… Sclerosis Secondary Progr…
The ASCEND Study did not achieve statistical significance on the primary or secondary endpoints.
-
NCT03074786
Details
2017-09-08
Interventional
20 
Dapivirine Emtricitabine Emtricitabine, … Tenofovir
HIV-1-infection
Study was transferred to partner who will conduct under its own IND
-
NCT01381549
Details
2017-09-08
Interventional
220 
Cilastatin Cilastatin, Imi… Imipenem
Communicable Di… Infections Pyelonephritis Urinary Tract I… Infections, Uri…
Microbiological findings of resistance on therapy in patients with complicated urinary tract infection
-
NCT02677948
Details
2017-09-06
Interventional
1/20 
Ibrutinib
Leukemia Leukemia, Lymph… Leukemia, Lymph… Lymphoma Chronic Lymphoc… Lymphoma, Small…
FDA has placed all trials involving Pacritinib on Full Clinical Hold
-
NCT00857324
2008-000646-32
Details
2017-09-06
Interventional
1/218 
Vorinostat
Multiple Myelom… Neoplasms, Plas…
The Phase I of the study was completed, but Phase 2 has not been activated
-
NCT01660893
Details
2017-09-05
Interventional
326 
Oxymetazoline Phenylephrine Tetracaine
Anesthesia
-
-
NCT01310738
Details
2017-09-05
Interventional
4
[1 Refs]
378 
Amphotericin B Amphotericin B,… Deoxycholic Aci… Liposomal ampho… Meglumine Antim…
Leishmaniasis Leishmaniasis, … Visceral Leishm…
DSMB recommendation based on programmed interim analysis.
-
NCT03126097
Details
2017-09-01
Interventional
118 
Drospirenone Drospirenone an… Ethinyl Estradi…
Healthy
Study stopping rules were met.
-
NCT01842633
Details
2017-09-01
Interventional
3365 
Acetaminophen Caffeine Ibuprofen
Headache Pain
-
Enrollment into the trial was terminated after randomization of 62% of the plan resulting in a significant reduction in study power. The originally planned inferential statistics (p-values) were therefore not presented in tables summarizing results.
NCT01217814
2010-021020-94
Details
2017-09-01
Interventional
216 
Folic Acid Golimumab Leucovorin Levoleucovorin Methotrexate
Arthritis Arthritis, Rheu… Rheumatoid Arth…
Due to delay in the study and the impact on the development timelines, not due to any identified safety concerns
The study was prematurely terminated due to small number of participants entering randomization.
NCT03264274
2014-002003-25
Details
2017-08-31
Interventional
20 
Aflibercept
Colorectal Neop… Colorectal Canc…
Funding restrictions - study never opened to recruitment
-
NCT02512601
Details
2017-08-31
Interventional
413 
Glucuronyl gluc…
Postphlebitic S… Postthrombotic … Syndrome Post-thrombotic…
Poor inclusion
-