Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00281879
Details
2017-09-27
Interventional
2200 
Antilymphocyte … Busulfan Carmustine Cyclophosphamid… Cyclosporine Cyclosporins Cytarabine Etoposide Fludarabine Fludarabine pho… Melphalan Methotrexate Methylprednisol… Mycophenolic Ac… Tacrolimus
Leukemia Lymphoma Multiple Myelom… Myelodysplastic… Myelodysplastic… Myeloproliferat… Neoplasms Neoplasms, Plas… Plasmacytoma Preleukemia Syndrome Chronic Myelopr… Multiple Myelom… Myelodysplastic… Unusual Cancers…
-
Early termination
NCT02278575
2012-005770-57
Details
2017-09-26
Interventional
4
[9 Refs]
0 
Antithrombin II… Antithrombins
Antithrombin II… Pre-Eclampsia
impossible to recruit participants due to organization changes
-
NCT01994642
Details
2017-09-26
Interventional
3203 
BB 1101 Ciprofloxacin Dexamethasone Dexamethasone a…
Otitis Otitis Media Otitis Media in…
FDA's draft guidance (revised March 2015) provided two options for determining bioequivalence: 1) in-vitro or 2) in-vivo studies
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NCT01689597
Details
2017-09-26
Interventional
40 
Morphine
Traumatic Vagin…
Withdrawn - no participants enrolled
-
NCT00016523
Details
2017-09-26
Interventional
3
[6 Refs]
420 
Nitric Oxide
Birth Weight Hypertension Hypertension, P… Respiratory Dis… Respiratory Dis… Respiratory Ins… Infant, Low Bir… Infant, Newborn Infant, Prematu… Infant, Small f… Pneumonia Respiratory Dis… Sepsis
Preliminary results showed increased intraventricular hemorrhage (IVH) in experimental arm
-
NCT00005776
Details
2017-09-26
Interventional
3
[5 Refs]
235 
Nitric Oxide
Hypertension Hypertension, P… Persistent Feta… Pneumonia Pneumonia, Aspi… Respiratory Dis… Respiratory Dis… Respiratory Ins… Syndrome Infant, Newborn
Results showed statistically significant benefit in the experimental group
-
NCT01887132
Details
2017-09-25
Interventional
25 
Donepezil
Autism Spectrum… Autistic Disord… Autism Spectrum…
-
Study terminated due to lack of recruitment. No conclusions regarding the use of donepezil can be drawn from small sample size data collection.
NCT00786318
Details
2017-09-25
Interventional
40 
Ziprasidone
Delirium Mental Disorder… Psychomotor Agi… Psychotic Disor… Agitation Psychosis
Sponsor terminated
-
NCT02788123
Details
2017-09-21
Interventional
49 
Bismuth Bismuth tripota… Pantoprazole
Stomach Disease… NSAID-induced G…
Internal reassessment of the medicinal product development strategy by Sponsor
-
NCT02062879
Details
2017-09-21
Interventional
320 
Hydromorphone Ketamine
Acute Pain Multiple Trauma Wounds and Inju… Fractures
Withdrawals from study due to anticipated effects from study drugs
-
NCT03283046
Details
2017-09-20
Interventional
10 
Dexamethasone Ipilimumab Lenalidomide Nivolumab
Multiple Myelom… Neoplasms Neoplasms, Plas… Malignant Neopl…
Similar to another study.
-
NCT01147042
Details
2017-09-20
Interventional
42 
Interferon-gamm… Interferons
Granuloma Granulomatous D… Immunologic Def… CGD - Chronic G… CGD Gene Mutati… CGD Response to… IFN-Gamma Thera… Immunodeficienc…
Early termination due to only 2 subjects completing trial.
Early termination due to only 2 subjects completing trial.
NCT00461812
Details
2017-09-20
Interventional
433 
Mometasone Furo…
Asthma
by sponsor due to failure to recruit patients who had mild persistent asthma who were not already on Advair 250/50 or 500/50.
-
NCT02111863
Details
2017-09-19
Interventional
26 
Aldesleukin Cyclophosphamid… Fludarabine
Melanoma Skin Neoplasms Skin Cancer
Study terminated due to low accrual and change in research focus.
-
NCT01508117
Details
2017-09-19
Interventional
21 
Axitinib
Glioblastoma Glioblastoma Mu…
transferred study sponsor
Early termination due to lack of accrual.
NCT02695290
Details
2017-09-18
Interventional
41 
Afatinib
Carcinoma, Non-… ErbB Receptors
-
This study was stopped prematurely when only 1 patient had received afatinib treatment so it was not possible to draw any conclusion.
NCT01765582
Details
2017-09-18
Interventional
2280 
Bevacizumab Capecitabine Fluorouracil Folic Acid Irinotecan Leucovorin Levoleucovorin Oxaliplatin
Colorectal Neop…
-
This trial was terminated on 12 November 2015, because the primary objective was not met.
NCT02576457
Details
2017-09-15
Interventional
135 
BMS-936559
Sepsis Toxemia Septic Shock Severe Sepsis
Business Objectives Have Changed
-
NCT03283410
Details
2017-09-14
Interventional
40 
Propofol
Anesthesia
Local problems with BIS monitor, we wont have it anymore.
-
NCT01360450
Details
2017-09-13
Interventional
2/312 
Clonidine
Neonatal Abstin… Opioid-Related …
The study was treminated because of low accural
-