Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01646762
Details
2017-10-16
Interventional
213 
Albumin-Bound P… Paclitaxel
Multiple Myelom… Neoplasms, Plas… Refractory Plas…
Did not pass the Stage 1 interim analysis.
-
NCT02049385
Details
2017-10-13
Interventional
1/210 
Diazoxide
Depression Depressive Diso…
Severe side effects & lack of target engagement
As only 1 participant completed both treatment arms, no formal statistical analysis of the primary outcome (MADRS) possible. Study halted due to severe side effects & lack of target (KATP channel) engagement measured by insulin sensitivity index.
NCT03190798
Details
2017-10-12
Interventional
40 
Canagliflozin
Cardiovascular … Diabetes Mellit… Diabetes Mellit… Type2 Diabetes …
Study has been withdrawn from IRB review pending IND revision
-
NCT02342600
Details
2017-10-12
Interventional
20 
Trametinib
Gastrointestina…
Supporting company withdrew interest
-
NCT03277755
Details
2017-10-11
Interventional
10 
Adafosbuvir
Hepatic Impairm…
Development program of JNJ-4178 was discontinued.
-
NCT02068157
Details
2017-10-11
Interventional
23 
Dihematoporphyr… Trioxsalen
Carcinoma Carcinoma, Squa… Carcinoma, Verr… Recurrence Squamous Cell C… Recurrent Laryn… Recurrent Laryn… Recurrent Lip a… Recurrent Metas… Recurrent Oral … Recurrent Oroph… Tongue Carcinom…
Study no longer has an active IDE
-
NCT00725946
Details
2017-10-11
Interventional
17 
Cadexomer iodin… Iodine
Breast Neoplasm… Breast Cancer Breast Cancer E… Breast Cancer M…
-
-
NCT02032654
2013-002106-31
Details
2017-10-10
Interventional
4151 
Floxacillin
Cellulitis Erysipelas
Budget exceeded
-
NCT02774512
Details
2017-10-06
Interventional
10 
Nilotinib
Colonic Neoplas… Colon Cancer
none participant has been enrolled and recruited during the first year after competent autority autorisation.
-
NCT02534129
Details
2017-10-06
Interventional
1/213 
Petrolatum
Dermatitis Radiodermatitis
Insufficient dermatitis was seen in the controls to allow any determination of protection by Difinsa53
This trial was terminated early, based on minimal radiation dermatitis (scores of 0-1 only in most fields evaluated) that precluded any meaningful analysis of any differing effect in the two treatment arms.
NCT01768988
Details
2017-10-06
Interventional
420 
Pregabalin
Cancer Pain Pancreatic Neop… Visceral Pain Pancreatic Canc…
Change of PI. Former PI changed from Research Center and Promoter obliged unexpectedly to change the PI.
-
NCT01688336
Details
2017-10-06
Interventional
29 
Folfirinox Irinotecan Leucovorin Oxaliplatin
Pancreatic Neop… Pancreatic Canc…
Results unlikely to impact treatment patterns. Time to complete not justified.
-
NCT01511107
Details
2017-10-06
Interventional
2520 
Amoxicillin Amoxicillin-Pot… Clavulanic Acid Clavulanic Acid…
Otitis Otitis Media Acute Otitis Me…
The primary objective of the study was met.
-
NCT00001827
NCT00019903
Details
2017-10-06
Interventional
221 
Aldesleukin Freund's Adjuva… Sargramostim
Ovarian Neoplas… Ovarian Neoplas…
-
-
NCT01310803
Details
2017-10-05
Interventional
31 
Valrubicin
Carcinoma Carcinoma in Si… Carcinoma, Tran… Non-Muscle Inva… Non-muscle Inva… Transitional Ce…
-
This study was terminated early. Only one subject was enrolled. No study results were generated.
NCT03002454
Details
2017-10-03
Interventional
34 
Sodium Pertechn… Technetium Tc 9…
Bone Neoplasms Cancer of Bone
Altered biodistribution in investigational images versus standard images.
Early termination. Despite a relatively comprehensive review of the first four subject's bone imaging scans a cause of an observed altered biodistribution is not apparent. As such study recruitment will be terminated.
NCT01399593
2010-019630-28
Details
2017-10-03
Interventional
2102 
Eculizumab
Antibody Mediat…
Did not achieve statistical significance for primary endpoint
Data interpretation confounded by open-label study with potential reporting bias, unequal exposure to randomized prevention therapy between groups, some patients in SOC arm received eculizumab for treatment of AMR, all patients immunosuppressed.
NCT00994253
Details
2017-10-02
Interventional
40 
Aliskiren Hydrochlorothia…
Diabetes Mellit… Hypertension Diabetes Type 2
Due to safety concerns re: the concomitant use of aliskiren with an ACEi or ARB.
-
NCT02113735
Details
2017-09-27
Interventional
20 
Adrenocorticotr…
Acute Lung Inju… Respiratory Dis… Respiratory Dis… Syndrome Acute Respirato…
A company decision was made not to proceed with the study.
-
NCT01436305
Details
2017-09-27
Interventional
2
[1 Refs]
19 
Abatacept Alemtuzumab Basiliximab Methylprednisol… Mycophenolic Ac… Tacrolimus
Kidney Transpla… Renal Transplan…
Secondary to safety concerns plus change in Campath® (alemtuzumab) availability.
Enrollment of 210 participants was planned, but study was stopped after 19 participants enrolled due to safety concerns and change in alemtuzumab availability. Enrolled participants continued follow-up after enrollment ended.