Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00188045
Details
2017-11-01
Interventional
4-
Propranolol Spironolactone
Fibrosis Liver Cirrhosis… Alcoholic Cirrh…
-
-
NCT02728245
Details
2017-10-31
Interventional
20 
Dienogest
Endometriosis Ovarian Reserve
Placebo cannot be prepared
-
NCT00853944
Details
2017-10-30
Interventional
3-
Dipeptidyl-Pept… Sitagliptin Pho…
Islet Transplan…
Sponsor withdrew funding du to lack of enrollment. Lack of enrollment was due to decrease in number of islet transplant procedures
-
NCT00564460
NCT00547430
Details
2017-10-30
Interventional
30 
Finasteride
Hyperplasia Prostatic Hyper… Benign Prostati…
Change of practice pattern. Green light laser
-
NCT02302092
Details
2017-10-27
Interventional
313 
Cefepime
Communicable Di… Infections Urinary Tract I… Urinary Tract I…
Study was prematurely terminated due to administrative and strategic reasons
The study is limited as only 13 out of the original 80 participants planned entered the study, due to this none of the planned statistical analyses from the protocol could be carried out, and all results should be reviewed with caution.
NCT02108951
Details
2017-10-27
Interventional
320 
Nilotinib
Leukemia Leukemia, Myelo… Leukemia, Myelo… Philidelphia Po…
Study was terminated because of slow recruitment
The study was planned to enroll 130 patients. Study got terminated with 20 patients because of slow recruitment. Therefore, due to small sample size, the results cannot be considered clinical significant.
NCT02802995
Details
2017-10-26
Interventional
3
[1 Refs]
15 
Thrombin
Varicose Ulcer Stasis Ulcer
Resource issue
-
NCT02496975
Details
2017-10-26
Interventional
1/20 
Cyclosporine Cyclosporins
Brain Injuries Brain Injuries,… Wounds and Inju… Traumatic Brain…
Recent studies suggest that cyclosporine A has a very sharp biphasic dose-response problem that is going to make further clinical translation difficult.
-
NCT00964288
Details
2017-10-26
Interventional
116 
Lidocaine
Hyperalgesia Neuralgia Neuropathic Pai… Pain, Neuropath…
During treatment session 3, a subject had a pattern of AEs of severe intensity, suggestive of brainstem toxicity/encephalopathy during lidocaine/saline infusion
-
NCT02076243
Details
2017-10-25
Interventional
22 
Paclitaxel
Carcinoma Carcinoma, Squa… Cutaneous Squam…
Closed by sponsor
-
NCT00672204
Details
2017-10-25
Interventional
1/223 
Antilymphocyte … Sirolimus Thymoglobulin
Diabetes Mellit… Diabetes Mellit… Hypoglycemia Type 1 Diabetes…
Raptiva was withdrawn from the market
Early termination due to Raptiva being withdrawn from market
NCT03042325
Details
2017-10-20
Interventional
40 
Alogliptin
Diabetes Mellit… Diabetes Mellit…
Business decision, no safety or efficacy concerns
-
NCT02977611
Details
2017-10-18
Interventional
20 
Ferric Oxide, S…
Iron Deficienci… Iron Deficiency
FDA Clinical Hold
-
NCT02150473
2013-004604-19
Details
2017-10-18
Interventional
321 
Adalimumab
Arthritis Arthritis, Rheu… Rheumatoid Arth…
-
-
NCT02090296
Details
2017-10-18
Interventional
20 
Hydroxyurea
Anemia Anemia, Sickle … Sickle Cell Ane…
Participant withdrew consent
-
NCT02032134
Details
2017-10-18
Interventional
45 
Dimethyl Sulfox…
Thrombocytopeni… Primary Thrombo… Thrombocytopeni…
recruitment failure within the interval of available CRY BC-PLTs for the study
-
NCT01512199
Details
2017-10-18
Interventional
1/229 
Albumin-Bound P… Antibodies, Mon… Paclitaxel Trastuzumab
Breast Neoplasm… Metastatic Brea…
Improved, different standard of care caused business decision to terminate
-
NCT03311178
Details
2017-10-17
Interventional
1/215 
Dobutamine
Shock
Substudy 001B is not required at this stage of the PIP
-
NCT01602016
Details
2017-10-17
Interventional
299 
Folic Acid Leucovorin Levoleucovorin
Asperger Syndro… Autism Spectrum… Autistic Disord… Child Developme… Asperger's Synd… Autism Pervasive Devel…
Non-compliance
-
NCT00855413
Details
2017-10-17
Interventional
415 
Darunavir Etravirine Ritonavir
Acquired Immuno… Communicable Di… HIV Infections Infections Viremia Acute HIV Infec…
Study halted by sponsor due to slow enrollment.
Early termination prior to target enrollment due to slow enrollment limited analysis involving optional procedures. Lack of paired (baseline and followup) samples from optional procedures also limited ability to perform these analyses.