Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01738672
Details
2017-11-21
Interventional
216 
Entonox Nitrous Oxide
Labor Pain
-
The study was limited by its small size. Additionally, because all participants were recruited from Family Medicine clinics in Pittsburgh, these results may not be generalizable to other populations of pregnant women.
NCT01334710
Details
2017-11-21
Interventional
23 
Sorafenib
Carcinoma, Hepa… Liver Neoplasms Liver Cancer
safety issue observed on another hepatocellular study using OSI906
A second trial evaluating OSI906 in hepatocellular cancer was being run in parallel to this trial. There were safety signals in the second trial which led to stopping this trial.
NCT00194883
Details
2017-11-21
Interventional
4-
Hormones
Renal Insuffici… Renal Insuffici… Chronic Renal I…
-
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NCT02899026
Details
2017-11-20
Interventional
30 
Antibodies, Mon… Prednisone
Giant Cell Arte… Polymyalgia Rhe…
GSK decision to return rights to sirukumab to Janssen and discontinue sirukumab development in polymyalgia rheumatica.
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NCT02515851
Details
2017-11-20
Interventional
430 
Bupivacaine
Radius Fracture… Wrist Fractures Distal Radius F…
Unable to find sufficient drug naive patients
-
NCT00524589
Details
2017-11-20
Interventional
218 
Calcitriol Dexamethasone
Prostatic Neopl… Prostate Cancer
closed due to futility
-
NCT03261596
Details
2017-11-17
Interventional
40 
DMP 777 Mebendazole Piperazine Piperazine citr…
Ancylostomiasis Communicable Di… Hookworm Infect… Infections
In light of new evidence, the decision was made by the sponsor to not proceed.
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NCT02128841
Details
2017-11-17
Interventional
212 
Rivaroxaban
Aortic Valve Di… Anticoagulants Heart Valve Pro…
not enough patients
-
NCT01231555
Details
2017-11-17
Interventional
223 
Efavirenz
Acquired Immuno… HIV Infections Immunologic Def… Infections Infection, Huma…
-
-
NCT01199731
Details
2017-11-17
Interventional
230 
Etravirine
Acquired Immuno… HIV Infections Infections Infection, Huma…
The study was stopped due to safety concerns
Enrollment in this study was terminated prematurely on 01 April 2011 due to a safety finding (convulsion) in 5/20 participants receiving GSK2248761.
NCT00825227
Details
2017-11-17
Interventional
210 
Modafinil
Fatigue Chemotherapy Si…
-
This trial was discontinued early after only 10 of 160 planned subjects had been recruited. No efficacy data was analyzed.
NCT00334646
Details
2017-11-17
Interventional
125 
Casopitant Cyclophosphamid…
Nausea Vomiting Nausea and Vomi…
compound terminated
-
NCT02556333
Details
2017-11-14
Interventional
21 
Emtricitabine Tenofovir
HIV
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The study was approved in late 2015, with the first and only patient enrolled in Jan 2016. The drug was approved in April 2016, which resulted in termination of the protocol.
NCT01777737
Details
2017-11-14
Interventional
33 
Trimethoprim, S…
Fibrosis Idiopathic Pulm… Pulmonary Fibro…
Changes in standards of care
-
NCT00622401
NCT00731406
Details
2017-11-14
Interventional
1/28 
Interleukin-12 Vaccines
Breast Neoplasm… Breast Cancer
-
In the conduct of the study, it became apparent that the setting of advanced breast cancer with malignant effusions/ascites for vaccine generation was a difficult setting for evaluation of an immune based therapy.
NCT00158886
Details
2017-11-14
Interventional
126 
Topotecan
Carcinoma, Rena… Rectal Neoplasm…
-
-
NCT01748162
Details
2017-11-13
Interventional
310 
Fluticasone Prednisolone
Croup Laryngitis
-
-
NCT01066000
Details
2017-11-13
Interventional
433 
Epoetin Alfa
Anemia
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This was an open-label, single arm study with no control arms for comparison of results from this study. The study was prematurely terminated due to high screening failures and low recruitment rate. Therefore, the data only showed a trend.
NCT00570674
Details
2017-11-13
Interventional
1/229 
Albumin-Bound P… Carboplatin Cetuximab Paclitaxel
Carcinoma Carcinoma, Aden… Carcinoma, Squa… Head and Neck N… Squamous Cell C… Adenosquamous C… Basaloid Squamo… Squamous Cell C… Undifferentiate…
The study did not continue to phase II due to the importance of HPV status as a prognostic factor to guide treatment decisions.
The phase II portion planned to enroll 34 participants including the expansion cohort but the study did not continue beyond phase I given the importance of HPV status as a prognostic factor to guide treatment decisions.
NCT00490568
Details
2017-11-13
Interventional
31461 
Rosiglitazone
Alzheimer Disea… Alzheimer's Dis…
Based on preliminary parent study results
-