Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02298153
Details
2017-12-11
Interventional
129 
Atezolizumab
Carcinoma Carcinoma, Non-… Carcinoma, Tran… NSCLC (Non-smal… UC (Urothelial …
Study halted prematurely and will not resume; participants are no longer being examined or receiving intervention.
-
NCT01934192
Details
2017-12-11
Interventional
291 
Metoclopramide
Critical Illnes… Gastroparesis
-
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NCT01890694
Details
2017-12-11
Interventional
42 
Tolvaptan
Hyponatremia
-
Due to the small sample size, data was not able to be analyzed.
NCT03266159
Details
2017-12-08
Interventional
20 
Trametinib
Solid Tumours
Study withdrawn before active to fully evaluate impact of changing practice in target population.
-
NCT00226941
Details
2017-12-08
Interventional
1/223 
Capecitabine Cetuximab Diphenhydramine Oxaliplatin Promethazine
Rectal Neoplasm… Colo-rectal Can… Rectal Cancer
The response rate observed in the phase 1 portion of the study did not merit further evaluation in phase 2 portion of the study.
This trial was halted after the phase 1 portion of enrollment, and before the phase 2 portion accrued. Data reported for phase 2 objectives/outcomes do not include any phase 2 participants, and are only provided for completeness.
NCT01345669
2011-000392-14
Details
2017-12-07
Interventional
3617 
Afatinib
Head and Neck N…
-
The trial was stopped prematurely due to futility.
NCT00460759
Details
2017-12-07
Interventional
115 
Moxifloxacin Rifapentine
Mycobacterium I… Tuberculosis Mycobacterium T…
-
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NCT03245671
Details
2017-12-06
Interventional
40 
BB 1101 Dexamethasone Dexamethasone 2… Dexamethasone a… Triamcinolone A…
Constriction, P… Spinal Stenosis Lumbar Spinal S…
Unable to address regulatory concerns.
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NCT02049801
Details
2017-12-06
Interventional
11 
Cytarabine Idarubicin
Leukemia Leukemia, Eryth… Leukemia, Monoc… Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Adult Acute Min… Adult Acute Mon… Adult Acute Mon… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Erythrole… Adult Pure Eryt… Recurrent Adult…
logistics
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NCT01908803
Details
2017-12-06
Interventional
284 
Ciprofloxacin Dexamethasone
Otitis Otitis Media Acute Otitis Me…
Management decision
-
NCT01740401
Details
2017-12-06
Interventional
210 
Cyclophosphamid… Ipilimumab
Melanoma
Primary Endpoint not met
-
NCT02452528
Details
2017-12-05
Interventional
24 
Diphenhydramine Entecavir Promethazine Tenofovir
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch… Hepatitis, Chro… Chronic Hepatit…
Company decision to discontinue trial
-
NCT01343368
Details
2017-12-05
Interventional
219 
Leuprolide
Hodgkin Disease Multiple Myelom… Myeloproliferat… Acute Myeloid L… Non-Hodgkin Lym…
-
-
NCT01342770
Details
2017-12-05
Interventional
26 
Pioglitazone
Carcinoma Carcinoma, Non-… Lung Neoplasms Stage IA Non-Sm… Stage IB Non-Sm… Stage IIA Non-S… Stage IIB Non-S… Stage IIIA Non-…
-
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NCT00655824
Details
2017-12-05
Interventional
2124 
Ofatumumab
Arthritis Arthritis, Rheu…
The clinical development of intravenously administered ofatumumab in RA will no longer be pursued, so this study was prematurely terminated by the Sponsor.
Development of the IV route of ofatumumab (OFA) administration in RA will no longer be pursued. This study was prematurely terminated; OFA treatment was discontinued. Participants could complete only <=7 treatment courses and a follow-up evaluation.
NCT00176839
Details
2017-12-05
Interventional
2/311 
Antilymphocyte … Busulfan Cyclophosphamid… Lenograstim Melphalan
Hematologic Neo… Leukemia, Lymph… Neoplasms Precursor Cell … AML Leukemia, Lymph… MDS
Replaced by a different study
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NCT02350426
Details
2017-12-04
Interventional
110 
Fluorodeoxygluc…
Arthritis Arthritis, Rheu… Inflammation
A decision to stop the study was made by the site and GSK project team based on pre-defined stopping criteria in the protocol
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NCT02138825
2010-024332-42
Details
2017-12-04
Interventional
2147 
Riociguat
Hamman-Rich Syn… Hypertension Hypertension, P… Idiopathic Inte… Lung Diseases, … Pneumonia Pulmonary Fibro… Idiopathic Inte…
Study terminated per recommendation of iDMC. On iDMC request, protocol amended to include 4-month safety follow-up for patients after withdrawal of riociguat.
The study was prematurely terminated following a recommendation from the independent Data Monitoring Committee, as patients receiving Riociguat showed an increased risk of mortality and serious adverse events as compared to patients receiving Placebo
NCT02118311
Details
2017-12-02
Interventional
20 
Cyclophosphamid… Fludarabine
Hematologic Neo… Neoplasms Hematologic Mal…
Changing study design. Will replace with a different protocol.
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NCT01639456
Details
2017-12-02
Interventional
20 
Aldesleukin Cyclophosphamid… Fludarabine
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myelogeno…
study was abandoned and a new study was written to replace this one
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