Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00360971
Details
2017-12-26
Interventional
321 
Cisplatin
Head and Neck N… Mucositis Stomatitis Head and Neck C… Pain Radiation Toxic…
Due to positive preliminary results from other palifermin studies.
This study terminated early with 21 subjects accrued out of 298 planned, therefore no statistical testing was performed. The termination was decided due to positive preliminary results from other palifermin studies.
NCT03059303
Details
2017-12-22
Interventional
172 
Dexlansoprazole Lansoprazole Odalasvir Omeprazole Simeprevir
Healthy
Decision to discontinue development of investigational Hep C treatment regimen JNJ-4178: 3 direct acting antivirals - AL-335, ODV & SMV.
-
NCT02412917
Details
2017-12-22
Interventional
3237 
Valacyclovir
Herpes Zoster Neuralgia Neuralgia, Post… Postherpetic Ne… Shingles
-
-
NCT01377441
Details
2017-12-22
Interventional
46 
Anti-Inflammato… Anti-Inflammato… Ibuprofen
Inflammatory Re…
Samples lost during Hurricane Sandy. Study now taking place at other medical centers.
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NCT00407641
Details
2017-12-22
Interventional
40 
Dalteparin Heparin Heparin, Low-Mo… Tinzaparin
Diabetes Mellit… Hemodialysis
Financial and administrative matters did not allow collaboration among centers.
-
NCT00384657
Details
2017-12-22
Interventional
30 
Ferric Oxide, S… Iron
Anemia Heart Failure Kidney Diseases Renal Insuffici… Chronic Heart F… Chronic Kidney …
Lack of cooperation among centers, Financial reasons
-
NCT02263365
Details
2017-12-20
Interventional
340 
Antidiarrheals Loperamide
Dehydration Dehydration, Di…
Unable to meet study requirements
Study only accrued 40 patients. Due to issues with enrollment and study procedures compliance it was decided to terminate the study. Data analysis will not be done for this study. This study has been closed with the internal review board.
NCT03307941
2016-000935-42
Details
2017-12-19
Interventional
1/20 
Fluorouracil Oxaliplatin
Adenocarcinoma Esophageal Neop… Esophageal Squa… Adenocarcinoma … Adenocarcinoma … Squamous Cell C…
Suspended collaboration with the company providing the study drug
-
NCT01394523
Details
2017-12-19
Interventional
2/339 
Bupivacaine
Hernia, Umbilic… Umbilical Herni…
Interim power analysis was prohibitive to continuing the study
-
NCT01051791
Details
2017-12-19
Interventional
213 
Everolimus
Carcinoma Carcinoma, Squa… Squamous Cell C… Squamous Cell C…
-
-
NCT02831205
Details
2017-12-15
Interventional
4-
Chromium Cobalt Everolimus
Coronary Artery… Coronary Diseas… Myocardial Isch… Percutaneous Tr…
Due to current BVS safety issue
-
NCT02047500
Details
2017-12-15
Interventional
119 
Gemcitabine Paclitaxel
Pancreatic Neop… Pancreatic Canc…
The trial has been terminated earlier following the company decision to discontinue the clinical development of Evofosfamide
-
NCT01469221
2011-003517-42
Details
2017-12-15
Interventional
347 
Apaziquone
Non-Muscle Inva… Urinary Bladder… Bladder Cancer
Business reason
-
NCT00585546
NCT00701116
Details
2017-12-15
Interventional
118 
Clenbuterol
Cardiomyopathie… Cardiomyopathy,… Heart Failure Dilated Cardiom…
No longer could obtain clenbuterol
Because a new standard of care was developed during the start of the trial, the trial was stopped for futility in enrollment. The public should exercise great caution in drawing conclusions from such a small sample size.
NCT03100877
Details
2017-12-13
Interventional
1/20 
Cyclophosphamid… Lenalidomide Lenograstim Mechlorethamine Melphalan Mitogens Nitrogen Mustar…
Leukemia, Plasm… Multiple Myelom… Neoplasms, Plas… Plasma Cell Leu… Plasma Cell Mye…
Feasibility Issues
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NCT01390506
2011-001074-26
Details
2017-12-13
Interventional
20 
Selenious Acid Sodium Selenite
Heart Arrest Cardiac Arrest
The company did not provide the study product
-
NCT02857244
Details
2017-12-12
Interventional
20 
Donepezil Duloxetine Hydr… Modafinil
Parkinson Disea… Parkinson's Dis…
Site did not obtain LIRB approval due to medication usage.
-
NCT02227329
Details
2017-12-12
Interventional
1/2
[1 Refs]
39 
Calcium heparin Ethanol Heparin
Communicable Di… Infections Sepsis Bloodstream Inf… Bloodstream Inf… Catheter-relate…
Publication of guidelines advising against the use of ethanol locks.
Due to European Society for Clinical Nutrition and Metabolism (ESPEN) guidelines on chronic intestinal failure in adults advising against ELT, we conducted an interim analysis. The study was terminated early; further study would not change outcome.
NCT02158936
Details
2017-12-12
Interventional
3356 
Azacitidine
Myelodysplastic… Preleukemia Syndrome Thrombocytopeni… Thrombocytopaen…
-
The IDMC recommended terminating the study for futility (primary) and safety (secondary). Due to early termination of the trial, the final analysis of OS took place at the same time as the final analysis of the primary end point.
NCT00794547
NCT00470431
Details
2017-12-12
Interventional
1/2
[1 Refs]
34 
Calcitriol
Carcinoma, Non-… Lung Neoplasms Non Small Cell …
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