Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02318563
Details
2018-01-04
Interventional
30 
Cannabidiol Pharmaceutical …
Epilepsies, Myo… Syndrome Dravet Syndrome
Sponsor elected not to continue with study.
-
NCT02318537
Details
2018-01-04
Interventional
30 
Cannabidiol Pharmaceutical …
Lennox Gastaut … Syndrome Lennox-Gastaut …
Sponsor elected not to continue with study.
-
NCT02138409
Details
2018-01-04
Interventional
30 
Fentanyl
Chronic Pain
Sponsor elected not to continue with study.
-
NCT00369070
Details
2018-01-04
Interventional
2186 
Bevacizumab Carboplatin Imetelstat Motesanib dipho… Paclitaxel
Carcinoma, Non-… Advanced Non-sq…
-
-
NCT02697851
Details
2018-01-02
Interventional
113 
Atazanavir Sulf… Cobicistat Ethinyl Estradi… Ethinyl Estradi… Ethinyl estradi… Levonorgestrel
HIV
Insufficient enrolment and "business reasons"
-
NCT01061671
Details
2018-01-02
Interventional
3885 
Simvastatin
Lung Diseases Pulmonary Disea…
Futility
Early termination by the Data and Safety Monitoring Board due to futility in respect to a treatment effect. The original study population goal was 1200 and the study was terminated at 885 participants.
NCT02993991
Details
2017-12-29
Interventional
10 
Durvalumab Mocetinostat
Carcinoma Carcinoma, Squa… Squamous Cell C… Resectable Squa… Squamous Cell C… Squamous Cell C…
The study has been terminated due to a change in internal prioritization and not due to any safety concerns.
-
NCT02701517
Details
2017-12-29
Interventional
2-
Alemtuzumab Cyclosporine Cyclosporins Methotrexate
Neoplasms Unrecognized Co…
The trial was stopped before the targeted number of patients was reached due to lack of support.
-
NCT01800162
Details
2017-12-29
Interventional
1/22 
Methotrexate
Cardiac Complex… Pregnancy, Ecto… Ectopic Pregnan… Persistent Preg…
A new protocol was written to replace this protocol.
-
NCT01332617
Details
2017-12-29
Interventional
20 
Bendamustine Hy… Bortezomib Diclofenac Methylprednisol… Methylprednisol… Methylprednisol… Prednisolone Prednisolone ac… Prednisolone he… Prednisolone ph… Simvastatin Zoledronic Acid
Multiple Myelom… Neoplasms, Plas… Myeloma
Investigators no longer interested in activating study
-
NCT01938833
Details
2017-12-28
Interventional
1/29 
Albumin-Bound P… Paclitaxel Romidepsin
Breast Neoplasm… Breast Neoplasm… Inflammatory Br… HER2-negative B… Inflammatory Br… Male Breast Can… Recurrent Breas… Stage IV Breast…
Closed by Sponsor
-
NCT00871689
Details
2017-12-28
Interventional
22 
Aldesleukin Cyclophosphamid… Fludarabine Fludarabine pho… Interleukin-2
Leukemia
Due to graft failure.
Quantitative, phenotypic and functional assessment of the in vivo expanded UCB-derived NK cells on Day 72 were not performed. Patients were not well enough to provide research samples.
NCT00790296
Details
2017-12-28
Interventional
211 
Hormones Thyrotropin-Rel…
Fatigue Cancer-related …
Interim analyses showed statistically and clinically significant results.
Limitation: small sample size
NCT00668564
Details
2017-12-28
Interventional
218 
Alemtuzumab Busulfan Cyclophosphamid…
Aphasia, Primar… Aspartylglucosa… Frontotemporal … Fucosidosis Leukodystrophy,… Mannosidase Def… Metabolism, Inb… Mucopolysacchar… Mucopolysacchar… Mucopolysacchar… Niemann-Pick Di… Niemann-Pick Di… Niemann-Pick Di… Niemann-Pick Di… Pick Disease of… Sphingolipidose… Syndrome Wolman Disease alpha-Mannosido… Alpha Mannosido… Hurler's Syndro… Krabbe Disease Maroteaux-Lamy … Niemann-Pick Di… Sly Syndrome Wolman's Diseas…
Replaced by another study
Other secondary objectives outlined in study protocol were not analyzed; number of patients were too few to be relevant.
NCT00625729
Details
2017-12-28
Interventional
1/26 
Aldesleukin Cyclophosphamid… Fludarabine Fludarabine pho… Rituximab
Leukemia Leukemia, Lymph… Leukemia, Lymph… Lymphoma Lymphoma, Non-H…
No patients exhibited natural killer cell expansion (primary endpoint).
Study was terminated early due to lack of NK expansion and failure to meet primary outcome.
NCT00617929
Details
2017-12-28
Interventional
212 
Antilymphocyte … Clofarabine Rituximab Thymoglobulin
Cancer
Replaced by another protocol
-
NCT00392782
Details
2017-12-28
Interventional
224 
Antilymphocyte … Fludarabine Fludarabine pho… Thiotepa
Leukemia Myelodysplastic… Preleukemia Syndrome
-
-
NCT00354172
Details
2017-12-28
Interventional
216 
Aldesleukin Cyclophosphamid… Cyclosporine Cyclosporins Fludarabine Fludarabine pho… Interleukin-2 Lenograstim Methylprednisol… Methylprednisol… Methylprednisol… Mycophenolic Ac… Prednisolone Prednisolone ac… Prednisolone he… Prednisolone ph…
Leukemia Myelodysplastic… Preleukemia Syndrome
Competing study was started.
-
NCT00352118
Details
2017-12-28
Interventional
24 
Docetaxel Fluorouracil Lenograstim
Head and Neck N… Head and Neck C…
Low dose radiation treatment was not appropriate for these patients.
All 4 patients received high dose radiation (66-70 Gy). The radiation oncologist on this study deemed low dose radiation treatment was not appropriate for these patients. Therefore, the study participants are not evaluable.
NCT01803711
Details
2017-12-27
Interventional
2/36 
Desvenlafaxine …
Cardiovascular … Depression Depressive Diso… Cancer Diabetes Major Depressio…
Lack of recruitment and no resources
Due to very low enrollment in both arms, only descriptive analyses was completed for both arms