Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02983097
2009-010824-25
Details
2018-01-19
Interventional
1/234 
Carboplatin Cytarabine Dexamethasone Lenalidomide Rituximab
Aggression Burkitt Lymphom… Lymphoma Lymphoma, B-Cel… Lymphoma, Large… Lymphoma, Mantl… Lymphoma, Non-H… Aggressive Marg… Burkitt Lymphom… Diffuse Large B… Follicular Lymp… Mantle Cell Lym…
Phase II: no scientific interests are given anymore
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NCT00126568
Details
2018-01-19
Interventional
220 
Sorafenib
Thyroid Carcino… Thyroid Disease… Thyroid Neoplas… Anaplastic Thyr… Recurrent Thyro…
-
The study met the pre-specified criteria for enrollment of all planned 32 patients. However due to poor accrual the study was halted.
NCT00864175
Details
2018-01-18
Interventional
1/268 
Docetaxel Trastuzumab
Breast Neoplasm… Breast Cancer
Incyte suspended development of the compound.
-
NCT03401606
Details
2018-01-17
Interventional
498 
Dexmedetomidine Remifentanil
Cataract Failed Consciou…
a respiratory depression in remifentanyl group
-
NCT02297490
Details
2018-01-17
Interventional
2158 
Immunomodulatin…
Allergic Rhinoc… Healthy Volunte…
The study was terminated due to the interim Analysis results indicating a weaker correlation than anticipated and reported by other study groups.
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NCT02155309
Details
2018-01-17
Interventional
2/363 
Butylscopolammo… Scopolamine
Motion Sickness
Business reason
-
NCT01132521
Details
2018-01-17
Interventional
4
[3 Refs]
252 
Trypsin Inhibit… Urinastatin
Pancreatitis
Revised project
-
NCT00303888
Details
2018-01-17
Interventional
131 
Docetaxel
Carcinoma, Ovar… Fallopian Tube … Peritoneal Neop… Fallopian Tube … Ovarian Cancer Primary Periton…
-
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NCT03108729
Details
2018-01-16
Interventional
30 
Eslicarbazepine…
Epilepsy
The study was not withdrawn for safety reasons. The sponsor received approval for the treatment of partial-onset seizures in patients 4 years of age and older
-
NCT02479490
Details
2018-01-16
Interventional
28 
Everolimus Prednisone
Carcinoma, Rena… Kidney Neoplasm… Metastatic Rena…
-
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NCT02968121
Details
2018-01-12
Interventional
122 
Brexpiprazole
Schizophrenia
Part A of study was completed per protocol. Conduct of Part B of the study (confirmatory phase) was not necessary.
-
NCT03005184
Details
2018-01-11
Interventional
20 
Enalapril Icatibant Sacubitril and … Valsartan
Heart Failure Heart Failure N… Heart Failure N… Heart Failure N…
Study is being redesigned and submitted as a new study.
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NCT03094468
Details
2018-01-10
Interventional
30 
Terbinafine
Onychomycosis Onychomycosis o…
Project development priorities changed
-
NCT03079973
NCT03209388
Details
2018-01-10
Interventional
30 
Calcipotriene
Psoriasis Nail Psoriasis
Project development priorities changed.
-
NCT02908165
Details
2018-01-10
Interventional
20 
Chlorotrianisen… Sorafenib
Carcinoma, Hepa… Hepatocellular …
A future study will be taking place using the same patient population.
-
NCT00470548
Details
2018-01-10
Interventional
1/2
[1 Refs]
49 
Albumin-Bound P… Paclitaxel Pemetrexed
Breast Neoplasm… Lung Neoplasms Breast Cancer Lung Cancer Unspecified Adu…
Practice patterns with pemetrexed have evolved.
The phase II portion accrued 37 patients before early closure due to increasing the first-line pemetrexed/platinum doublet use in non-squamous NSCLC.
NCT03343678
2014-004957-16
Details
2018-01-09
Interventional
10 
BI 836826 Venetoclax
Leukemia Leukemia, Lymph… Leukemia, Lymph…
Company strategic decision
-
NCT02569437
Details
2018-01-09
Interventional
249 
Doxycycline Fluticasone Methylprednisol… Methylprednisol… Methylprednisol… Prednisolone Prednisolone ac… Prednisolone he… Prednisolone ph…
Nasal Polyps Polyps Rhinosinusitis Polyp of Nasal …
A high percentage of patients were dropping out of the study and were not able to complete the protocol.
Power not adequate and study is at risk for a Type II error - study was ended prior to complete sample size accrual. Study recruited high percentage of severe disease patients, thus did not accurately represent moderate disease patients.
NCT01261299
Details
2018-01-09
Interventional
121 
Carboplatin
Carcinoma, Non-… Neoplasms Urinary Bladder…
Contract ended
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NCT03238638
Details
2018-01-04
Interventional
20 
Pembrolizumab
Head and Neck N… Head and Neck C…
PI did not attempt to open the study.
-