Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01822756
Details
2018-02-12
Interventional
142 
Gemcitabine Paclitaxel
Pancreatic Canc… Solid Tumors
Dose escalation ended after Cohort B1, RUX 10 mg BID - GCSF in October 2014.
In October 2014, further enrollment of additional study cohorts was stopped; Part 2 of the study wasn't conducted. Pharmacokinetic and Pharmacodynamics analyses weren't performed due to early termination. Maximum tolerated dose (MTD) was not reached.
NCT01484041
Details
2018-02-09
Interventional
1/212 
Aromatase Inhib…
Breast Neoplasm… Breast Cancer
Decision by company to cease development of dovitinib
-
NCT01002248
Details
2018-02-09
Interventional
3
[1 Refs]
135 
Bortezomib Dexamethasone
Multiple Myelom… Neoplasms, Plas…
-
-
NCT00723918
Details
2018-02-09
Interventional
20 
Methadone
Peripheral Nerv… Polyneuropathie… HIV-associated … Polyneuropathy
Withdrawal of pharmaceutical support from Novartis - no participants randomized
-
NCT03325868
Details
2018-02-08
Interventional
40 
Ulipristal acet…
Adenomyosis Dysmenorrhea Hemorrhage Uterine Hemorrh… Heavy Uterine B…
IND issues
-
NCT01702909
Details
2018-02-08
Interventional
27 
Interleukin-2
Carcinoma, Rena… Kidney Neoplasm… Neoplasms Kidney Cancer M… Renal Cell Canc…
PI Decision
-
NCT01279187
Details
2018-02-07
Interventional
227 
Teriparatide
Implant
Study was terminated due to patient complications unrelated to study drugs
-
NCT00491387
Details
2018-02-07
Interventional
424 
Metoprolol
Hypertension
Adverse events reported with beta-blockers as primary therapy.
Early termination due to a publication in the literature suggesting potential increased cardiac mortality in hypertensive patients treated primarily with beta blockers. Did not feel that continued treatment in volunteer subjects could be justified.
NCT03422874
Details
2018-02-06
Interventional
10 
Ixazomib Nelfinavir
Lymphoma Neoplasms
Sponsor withdrew support
-
NCT02736435
Details
2018-02-06
Interventional
30 
Leuprolide
Leiomyoma Myofibroma Uterine Leiomyo…
Lengthy delays and inadequate support to proceed.
-
NCT01882530
Details
2018-02-06
Interventional
4223 
Acetaminophen Ketoprofen Morphine Nefopam
Agnosia Post Operative …
Practice on postoperative pain management changed
-
NCT01142323
Details
2018-02-06
Interventional
1/28 
Fenofibrate
Cholangitis Cholangitis, Sc… Primary Scleros…
-
-
NCT01668550
Details
2018-02-05
Interventional
143 
AZD-0424
Neoplasms Advanced Solid …
Single agent phase completed, insufficient supportive preclinical data to proceed with combination phase
-
NCT01636466
Details
2018-02-05
Interventional
31 
Everolimus
Kidney Failure,… Renal Insuffici…
Feasibility
-
NCT00095862
Details
2018-02-05
Interventional
1/2-
Cyclophosphamid… Interferon-alph… Interferons
Breast Neoplasm… Breast Cancer Unspecified Adu…
-
-
NCT02040909
2013-005572-17
Details
2018-02-01
Interventional
191 
Propofol
Premature Birth Anesthesia Intu… Other Preterm I… Premature Birth… Propofol Overdo…
interim results concluded no added value of additional inclusion
-
NCT01773616
Details
2018-02-01
Interventional
324 
Methylprednisol… Methylprednisol… Methylprednisol… Mycophenolic Ac… Prednisolone Prednisolone ac… Prednisolone he… Prednisolone ph… Rituximab
Lupus Erythemat… Lupus Nephritis Nephritis Systemic Lupus …
Study assessments for patients recruited continuing per protocol so patients receive a minimum of 6 months follow up. No safety concerns have been raised.
-
NCT01565590
Details
2018-02-01
Interventional
34 
Dexmedetomidine Propofol
Hemorrhage Subarachnoid He… Subarachnoid He…
Slow enrollment along with new competing studies, investigators decided to stop study
-
NCT02815059
Details
2018-01-31
Interventional
10 
Dasatinib Ibrutinib Prednisone
Leukemia Leukemia, Lymph… Philadelphia Ch… Precursor Cell … Acute Lymphobla…
Termination of Investigator Initiated Studies using Ibrutinib
-
NCT02488616
Details
2018-01-31
Interventional
20 
Hormones Insulin Insulin, Globin…
Diabetes Mellit… Diabetes Mellit… Type 1 Diabetes
Medtronic support terminated
-