Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02271295
Details
2018-02-27
Interventional
316 
Enoxaparin
Fibrosis Cirrhosis
Premature discontinuation of inclusions by the sponsor for low inclusion
-
NCT02223598
Details
2018-02-27
Interventional
1-
Dexamethasone
Hematologic Neo… Multiple Myelom… Neoplasms Lymphoid Hemato… Relapsed and Re…
MTD determined
-
NCT01919346
Details
2018-02-27
Interventional
221 
Eculizumab
Delayed Graft F… Complement Acti… Kidney Transpla…
Based on results from Alexion PROTECT DGF study
-
NCT03202446
Details
2018-02-23
Interventional
318 
Chitosan Cyclophosphamid…
Breast Neoplasm… Breast Cancer S… Breast Cancer S… Breast Cancer, …
-
-
NCT02371590
Details
2018-02-23
Interventional
20 
Lenalidomide Obinutuzumab
Leukemia Leukemia, Lymph… Leukemia, Lymph… Chronic Lymphoc…
Study Not Activated Due to Contract Issues
-
NCT01290601
Details
2018-02-23
Interventional
270 
Chloroquine Chloroquine dip… Primaquine Tafenoquine
Malaria Plasmodium Viva…
Failure to meet pre-specified endpoint for the day 28 cure rate
IDMC determined that Cohort 1 failed to meet specified endpoint for d28 cure rate; Cohort 2 wasn't initiated and follow-up in Cohort 1 should be completed according to protocol. Following last subjects last visit for Cohort 1 study was terminated.
NCT02498496
Details
2018-02-22
Interventional
40 
Magnesium Sulfa…
Lung Diseases Lung Diseases, … Pulmonary Disea…
financing delays
-
NCT01255163
Details
2018-02-22
Interventional
257 
Exenatide
Alzheimer Disea… Cognitive Dysfu… Alzheimer's Dis… Mild Cognitive …
AstraZeneca withdrew support for the study.
The study was terminated after AstraZeneca withdrew support. Early termination lead to small number of subjects analyzed.
NCT00268242
Details
2018-02-22
Interventional
224 
Gemcitabine Mitoxantrone
Leukemia Leukemia, Myelo… Leukemia, Myelo…
If
If 4 of 1st 10 or 10 of 1st 25 pts had unacceptable toxicity per protocol & Common Toxicity Criteria for Adverse Effects (CTCAE) v3.0
NCT01936974
Details
2018-02-20
Interventional
27 
Bevacizumab Carboplatin Gemcitabine Oxaliplatin
Carcinoma Fallopian Tube … Ovarian Carcino… Peritoneal Carc…
PI Decision
-
NCT03081039
Details
2018-02-19
Interventional
30 
Carboplatin Gemcitabine
Cholangiocarcin… Intrahepatic Ch…
Competing study
-
NCT03036046
Details
2018-02-15
Interventional
1/20 
Fluconazole Olorofim Posaconazole
Leukemia Acute Myeloid L…
Study no longer required
-
NCT02856178
Details
2018-02-15
Interventional
1/20 
Caspofungin Olorofim
Aspergillosis Invasive Pulmon… Leukemia Leukemia, Myelo… Leukemia, Myelo… Pulmonary Asper… Acute Myeloid L… Pulmonary Asper…
study no longer required
-
NCT02578511
Details
2018-02-15
Interventional
10 
Ixazomib
Acute Disease Leukemia Leukemia, Lymph… Lymphoma Lymphoma, Non-H… Pathologic Comp… Precursor Cell … Acute Lymphobla… Lymphoblastic L… Mixed Phenotype…
No enrollment, another competing study and difficult to find the right person to enroll on this study.
-
NCT00388700
Details
2018-02-14
Interventional
20 
Bevacizumab Fluorouracil Leucovorin
Colorectal Neop… Colorectal Canc…
Financing and re-organization
-
NCT00379912
Details
2018-02-14
Interventional
2
[1 Refs]
15 
Azacitidine Epoetin Alfa
Myelodysplastic… Preleukemia Syndrome
Insufficient response rate
Results of interim analysis led to early closure of the study.
NCT02120417
Details
2018-02-13
Interventional
2149 
Capecitabine
Breast Neoplasm… Breast Cancer
The study was terminated as other related studies of ruxolitinib did not provide sufficient efficacy to warrant continuation.
-
NCT02119663
Details
2018-02-13
Interventional
386 
Capecitabine
Pancreatic Neop… Pancreatic Canc…
The safety committee found no safety issues but recommended halting the study based on a lack of efficacy in a similar trial. The sponsor terminated the trial.
The study was terminated prior to the final analysis at the recommendation of the Data Monitoring Committee based on the review of efficacy in the 18424-362 (JANUS 1).
NCT01601626
Details
2018-02-13
Interventional
271 
Ethambutol Isoniazid Lopinavir Pyrazinamide Pyridoxine Raltegravir Pot… Rifabutin Rifampin Ritonavir Vitamin B 6
Tuberculosis HIV Infection
The study was stopped early due to feasibility concerns.
The study was terminated after 71 of 471 participants enrolled. Therefore, the study was under-powered and formal statistical comparisons between study arms were not undertaken as originally planned. Instead, summaries within study arm were provided.
NCT00878215
Details
2018-02-13
Interventional
240 
Liver Extracts
Carcinoma, Hepa… Liver Neoplasms Hepatocellular …
The image-guidance system became commercially available
-