Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00974922
Details
2018-03-09
Interventional
440 
Aliskiren Cholecalciferol Vitamin D
Hypertension Vitamin D Defic…
Administrative/Sponsor Business Decision - terminated - study was not completed
Study was never completed due to early termination of the trial by sponsor. Data were never analyzed because group assignment was never un-blinded and data lacked any scientific utility.
NCT00096265
Details
2018-03-09
Interventional
3126 
Erlotinib Hydro… Temozolomide
Brain Neoplasms Carcinoma, Non-… Lung Neoplasms Neoplasms Metastatic Mali… Recurrent Non-S… Stage IV Non-Sm…
-
This study stopped accrual early due to unmet targeted accrual goals with 126 subjects accrued out of 381 planned.
NCT03456401
2014-001956-52
Details
2018-03-07
Interventional
218 
Sorafenib Sunitinib
Kidney Neoplasm… Renal Cancer Ce…
availability of new and more promising therapeutic agents than expected in the experimentation in question
-
NCT03329547
Details
2018-03-07
Interventional
10 
Cefixime
Bacterial Infec… Infections, Bac…
Change in commercial strategy
-
NCT03239600
Details
2018-03-07
Interventional
20 
Methotrexate
Autoimmune Dise… Sjogren's Syndr…
The study is stopped for Portfolio prioritization.
-
NCT02354768
Details
2018-03-07
Interventional
319 
Antidiarrheals Lanreotide Loperamide
High Output Sto…
-
-
NCT01659099
Details
2018-03-07
Interventional
3671 
Bleomycin Cyclophosphamid… Doxorubicin Obinutuzumab Prednisone Rituximab Vincristine
Lymphoma Lymphoma, B-Cel… Lymphoma, Large… Diffuse Large B…
experimental treatment not Superior to standard - no need to continue the follow-up
-
NCT01313611
Details
2018-03-07
Interventional
262 
Bendamustine Hy… Rituximab
Lymphoma Lymphoma, Folli… Follicular Lymp…
Treament with rituximab during maintenance phase was stoped, according to DSMC recommendations, since 3 cases of deaths occured.
-
NCT03347994
Details
2018-03-06
Interventional
10 
14-O-phosphonoo…
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
Discordance in contractual language and terms.
-
NCT02503176
Details
2018-03-05
Interventional
3-
Ophthalmic Solu…
Dry Eye Syndrom… Keratoconjuncti… Sjogren's Syndr… Syndrome Dry Eye With Sj…
Discontinuation of the development
-
NCT03183492
Details
2018-03-02
Interventional
40 
Vaccines
Hepatitis Hepatitis A
Sponsor cancelled the study as real life impact data has already shown the value of HepA vaccination & as no critical need to gather additional data in Israel.
-
NCT02395783
Details
2018-03-02
Interventional
2/314 
Melatonin
Brain Injuries Leukoencephalop… Premature Birth
-
-
NCT01627379
2010-020606-15
Details
2018-03-02
Interventional
3-
Panitumumab
Carcinoma, Squa… Esophageal Squa… Neoplasms, Squa… Esophageal Squa…
Sponsor decision due to recommendation of the IDMC.
-
NCT01610570
Details
2018-03-02
Interventional
1/2
[1 Refs]
8 
Plicamycin
Sarcoma Sarcoma, Ewing Ewing Sarcoma
Study was closed to enrollment before dose level one was completed.
-
NCT03220867
Details
2018-02-28
Interventional
10 
Risperidone
Healthy
CFDA announced Xi'An Risperdal as reference drug, no need for this BE trial from both scientific and ethical perspective.
-
NCT02590003
Details
2018-02-28
Interventional
23 
Carboplatin Paclitaxel
Carcinoma, Non-… Carcinoma, Non-…
Trial was stopped after non-response to treatment.
-
NCT02374567
Details
2018-02-28
Interventional
3407 
Acamprosate Agomelatine Alprazolam Amisulpride Amitriptyline Aripiprazole Benperidol Biperiden Bromazepam Bromperidol Brotizolam Bupropion Buspirone Carbamazepine Chloral Hydrate Chlormethiazole Chlorprothixene Citalopram Clobazam Clomipramine Clonazepam Clopenthixol Clozapine Diazepam Diphenhydramine Donepezil Doxepin Duloxetine Hydr… Escitalopram Fluoxetine Flupenthixol Flupenthixol de… Fluphenazine Fluphenazine de… Fluphenazine en… Flurazepam Fluspirilene Fluvoxamine Gabapentin Galantamine Haloperidol Hydroxyzine Imipramine Lacosamide Lamotrigine Levetiracetam Lorazepam Lormetazepam Maprotiline Melatonin Memantine Methotrimeprazi… Mianserin Midazolam Mirtazapine Moclobemide Nicergoline Nitrazepam Nortriptyline Olanzapine Opipramol Oxazepam Oxcarbazepine Paliperidone Pa… Paroxetine Perazine Perphenazine Phenobarbital Phenytoin Pimozide Pipamperone Piracetam Pregabalin Promethazine Quetiapine Fuma… Reboxetine Risperidone Rivastigmine Sertindole Sertraline Sulpiride Temazepam Thioridazine Tiapride Hydroc… Topiramate Tranylcypromine Trazodone Triazolam Trimipramine Valproic Acid Venlafaxine Hyd… Zaleplon Ziprasidone Zolpidem Zopiclone
Anxiety Disorde… Psychophysiolog… Schizophrenia Somatoform Diso… Dementia Depression Psychosomatic D…
-
-
NCT02198482
2014-000477-39
Details
2018-02-28
Interventional
26 
Cytarabine Daunorubicin Mitoxantrone
Leukemia Leukemia, Myelo… Leukemia, Myelo… Myelodysplastic… Preleukemia Syndrome Acute Myeloid L… High-risk Myelo…
development program of study drug volasertib was stopped by Boehringer Ingelheim due to manufacturing problems
-
NCT03307603
Details
2018-02-27
Interventional
1/20 
Nivolumab
Colorectal Neop… Metastatic Colo…
Sponsor chose not to continue
-
NCT02342353
Details
2018-02-27
Interventional
18 
Erlotinib Hydro…
Carcinoma, Non-… Lung Neoplasms Non-Small Cell … Nonsmall Cell L…
Drug shortage
-