Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02833506
Details
2018-05-01
Interventional
10 
Sirolimus
Carcinoma Carcinoma, Ovar… Fallopian Tube … Ovarian Neoplas… Peritoneal Neop… Recurrence Recurrent Fallo… Recurrent Ovari… Recurrent Prima… Stage IIA Fallo… Stage IIA Ovari… Stage IIB Fallo… Stage IIB Ovari… Stage IIC Fallo… Stage IIC Ovari… Stage IIIA Fall… Stage IIIA Ovar… Stage IIIA Prim… Stage IIIB Fall… Stage IIIB Ovar… Stage IIIB Prim… Stage IIIC Fall… Stage IIIC Ovar… Stage IIIC Prim… Stage IV Fallop… Stage IV Ovaria… Stage IV Primar…
production of adjuvant to be used with vaccine was discontinued by sponsor
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NCT03417037
2017-003058-18
Details
2018-04-30
Interventional
30 
Linrodostat Nivolumab
Carcinoma, Non-… Lung Neoplasms Lung Cancer Non-Small Cell …
Business objectives have changed.
-
NCT02877082
Details
2018-04-30
Interventional
25 
Antilymphocyte … Bortezomib Tacrolimus Thymoglobulin
Graft vs Host D… Leukemia Leukemia, Lymph… Leukemia, Myelo… Leukemia, Myelo… Lymphoma Lymphoma, Large… Lymphoma, Mantl… Myelodysplastic… Myeloproliferat… Acute Leukemia Chronic Lymphoc… Chronic Myeloge… Diffuse Large B… Follicular Lymp… Graft Versus Ho… Mantle Cell Lym… Marginal Zone L… Myelodysplastic… Myelofibrosis Myeloproliferat… Small Lymphocyt…
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After monitoring early toxicity and hyperacute severe acute graft versus host disease in 4/5 patients, it was decided to close this protocol.
NCT02543645
Details
2018-04-30
Interventional
118 
Atezolizumab
Carcinoma Carcinoma, Rena… Kidney Diseases Kidney Neoplasm… Neoplasms Neoplasms by Hi… Triple Negative… Urogenital Neop… Urologic Diseas… Urologic Neopla… Bladder Cancer Clear-cell Meta… Head and Neck C… Melanoma Non-small Cell … Triple Negative…
Portfolio re-prioritization
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NCT03335501
Details
2018-04-27
Interventional
20 
Hormones Pancrelipase
Diabetes Mellit… Type 1 Diabetes…
The owner of the algorithm does not wish that this study be undertaken
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NCT03023904
Details
2018-04-25
Interventional
20 
Nivolumab
Carcinoma, Non-… Lung Neoplasms Recurrence Recurrent Non-S… Stage IV Non-Sm…
Research cancelled
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NCT02829814
Details
2018-04-25
Interventional
351 
Cyclobenzaprine
Collagen Diseas… Fibromyalgia Muscular Diseas… Musculoskeletal… Myofascial Pain… Nervous System … Neuromuscular D… Rheumatic Disea…
For business reason unrelated to safety or tolerability,Tonix has discontinued the Fibromyalgia development with TNX102 SL.
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NCT02589275
Details
2018-04-25
Interventional
3375 
Cyclobenzaprine
Fibromyalgia Myofascial Pain… Primary Fibromy…
For business reason unrelated to safety or tolerability,Tonix has discontinued the Fibromyalgia development with TNX102 SL.
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NCT02296840
Details
2018-04-25
Interventional
445 
Acetaminophen Acetaminophen, … Hydrocodone Ibuprofen
Drug-Related Si… Sleep Apnea Syn… Sleep Apnea, Ob… Tonsillitis Adverse Reactio… Obstructive Sle… Recurrent Tonsi… Sleep Disordere…
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Many participants did not completed the pain control survey, limiting the conclusions that can be made from this study.
NCT00626626
Details
2018-04-25
Interventional
1/2
[1 Refs]
8 
Alemtuzumab Clofarabine Cyclophosphamid…
Leukemia Leukemia, Myelo… Leukemia, Myelo… Lymphoma Multiple Myelom… Myelodysplastic… Preleukemia Chronic Myeloge… Hodgkin's Lymph… Myelodysplastic…
Investigator decision
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NCT02379585
Details
2018-04-24
Interventional
1/28 
Cyclophosphamid… Docetaxel Doxorubicin Paclitaxel Pertuzumab Trastuzumab
Breast Neoplasm… HER2-positive B…
PI Decision
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NCT02002377
Details
2018-04-24
Interventional
423 
Aflibercept
Macular Degener… Age Related Mac…
Inadequate enrollment due to investigational product becoming newly available on the Canadian market soon after study start
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NCT01331824
Details
2018-04-23
Interventional
222 
Amrubicin
Carcinoma, Tran… Urinary Bladder… Bladder Cancer
due to a development decision by the funder
The trial was terminated prematurely due to the results of a phase 3 study seeking registration for amrubicin in small cell lung cancer in the United States, leading the industry funder to discontinue further clinical development of amrubicin.
NCT00796328
Details
2018-04-23
Interventional
445 
Oxymetazoline Phenylephrine
Hypotension Spinal Induced …
Results Invalid, study closed, analysis cannot proceed.
-
NCT00977405
Details
2018-04-20
Interventional
2
[1 Refs]
-
Gentamicins
Surgical Wound … Superficial Sur…
-
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NCT00459108
Details
2018-04-19
Interventional
225 
Dasatinib
Carcinoma Carcinoma, Hepa… Liver Neoplasms Adult Primary H… Advanced Adult … Recurrent Adult…
Halted early for futility.
Study was terminated early after the first stage of a two-stage design, allowing for early termination for discouraging results.
NCT03253224
Details
2018-04-18
Interventional
424 
Magnesium Sulfa…
Pain, Postopera… Arthritis Knee Dexmedetomidine Magnesium Sulfa…
Because the principle investigator will participate a visiting scholar program for one year in other country, this study has been terminated.
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NCT02462265
Details
2018-04-18
Interventional
2-
Antineoplastic … Mitoxantrone
Leukemia Leukemia, Lymph… Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L… Lymphoid Leukem…
-
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NCT03498534
Details
2018-04-17
Interventional
40 
Isoniazid
Diabetes Mellit… Latent Tubercul… Tuberculosis
Due to administrative procedures
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NCT03069768
Details
2018-04-17
Interventional
10 
Varenicline
Tobacco Use Dis… Nicotine Depend…
Unable to obtain varenicline to provide to participants
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