Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01517165
Details
2018-07-05
Interventional
124 
Pioglitazone
Opioid-Related …
-
-
NCT01459679
Details
2018-07-05
Interventional
31721 
Ophthalmic Solu… Riboflavin
Corneal Disease… Dilatation, Pat… Keratoconus Corneal Ectasia
-
-
NCT01341496
Details
2018-07-05
Interventional
141 
Celecoxib Cyclophosphamid…
Melanoma Neoplasms Sarcoma Epithelial Mali… Pleural Maligna…
-
-
NCT01229644
Details
2018-07-05
Interventional
210 
Crenolanib
Glioma
-
-
NCT00005925
Details
2018-07-05
Interventional
13 
Muscimol
Epilepsy
-
-
NCT02403895
Details
2018-07-03
Interventional
211 
Paclitaxel
Carcinoma, Non-… Lung Neoplasms Squamous Non Sm…
-
Sponsor and Investigator decision was taken to terminate further recruitment into the study due to lack of observed responses rendering it futile to continue. As such, an abbreviated Clinical Study Report was produced based on data from 11 patients.
NCT01724619
Details
2018-07-03
Interventional
17 
Dihydrotestoste…
Prostatic Neopl… Prostate Cancer
Study tracer can no longer be obtained at our institution
-
NCT01135329
Details
2018-07-03
Interventional
215 
Busulfan Cyclophosphamid… Fludarabine Mycophenolic Ac… Tacrolimus
Leukemia Lymphoma Myelodysplastic… Preleukemia Myelodysplastic…
The stopping rule was met and hence the study was closed
-
NCT01059929
Details
2018-07-03
Interventional
441 
Dexmedetomidine Fentanyl Midazolam Propofol
Critical Illnes… Mechanical Vent…
drug and placebo unavailable
-
NCT02460016
Details
2018-07-02
Interventional
11 
Ziresovir
Infections Respiratory Syn… Virus Diseases
We switched this study design to another study per IEC's recommendations.
-
NCT02368197
Details
2018-07-02
Interventional
2/313 
Paclitaxel
Constriction, P… Fistula Dialysis Access…
-
-
NCT00845039
Details
2018-07-02
Interventional
24 
Antibodies, Mon… Cetuximab Irinotecan
Colonic Neoplas… Rectal Neoplasm… Colon Cancer Rectal Cancer
Study terminated early 22Feb2010 with only 4 participants due to business reasons.
Study terminated early 22Feb2010 with only 4 participants due to business reasons. Data were collected for too few participants to draw statistically meaningful conclusions and included concerns on participant confidentiality.
NCT00765375
Details
2018-06-29
Interventional
25 
Botulinum Toxin… Botulinum Toxin… abobotulinumtox…
Acne Vulgaris
Investigator decision
Study terminated after 5 subjects
NCT03506399
Details
2018-06-28
Interventional
10 
Contraceptive A… Contraceptives,… Estradiol Ethinyl Estradi… Levonorgestrel
Healthy
Stopped for futility. Phase 3 studies not likely to meet primary endpoints.
-
NCT01222871
Details
2018-06-28
Interventional
1/21 
Triamcinolone
Nasal Polyps
not enough particpants
-
NCT02862574
2016-000897-39
Details
2018-06-27
Interventional
215 
Methotrexate Tumor Necrosis …
Arthritis Arthritis, Rheu… Necrosis Rheumatoid Arth…
Study was terminated by sponsor and decision was not due to any safety signals.
Gilead decided to discontinue the development of andecaliximab in RA and this study was terminated. The decision was not due to any safety concerns. Because only 15 participants were enrolled, no formal statistical testing was completed.
NCT01579058
Details
2018-06-27
Interventional
420 
Bisoprolol
Aortic Valve St… Constriction, P… Aortic Stenosis
The sponsor discontinued to support the study.
-
NCT01050764
Details
2018-06-27
Interventional
1/210 
Antilymphocyte … Fludarabine Fludarabine pho… Melphalan Thiotepa Thymoglobulin Vidarabine
Leukemia Leukemia, Lymph… Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Lymphoma, Non-H… Myelodysplastic… Precursor Cell … Preleukemia Acute Lymphobla… Acute Myelogeno… Chronic Lymphoc… Chronic Myeloge… Leukemia, Acute Myelodysplastic… Non-Hodgkin Lym…
Safety
-
NCT02413489
2014-005299-26
Details
2018-06-26
Interventional
236 
Daratumumab
Lymphoma Lymphoma, Folli… Lymphoma, Large… Lymphoma, Mantl… Lymphoma, Non-H…
DLBCL and FL cohorts met the pre-specified futility criteria and will not proceed. The MCL cohort was terminated due to slow recruitment and aggressive disease.
The study was terminated due to 2 non-Hodgkin's lymphoma (NHL) sub types (DLBCL and FL cohorts) meeting the futility criteria defined in the protocol and the MCL cohort not having adequate recruitment.
NCT00543309
Details
2018-06-25
Interventional
2
[1 Refs]
106 
Milrinone Natriuretic Pep…
Congenital Abno… Heart Defects, …
DSMB recommended termination based on interim outcomes analysis
Single center design limits generalizability of findings. Study drug doses were extrapolated from published experience in other patient types. Study may have been underpowered to detect differences among treatment groups for secondary outcomes.