Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

Filter:

Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
Free Text
Annotations

7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01852292
2013-000744-26
Details
2018-07-24
Interventional
2157 
Paclitaxel
Carcinoma Carcinoma, Squa… Squamous Cell C… Head and Neck S…
-
-
NCT01825577
Details
2018-07-24
Interventional
414 
Methylphenidate
Dementia Accidental Fall… Apathy
Administrative Reasons
-
NCT00852332
2008-003930-19
Details
2018-07-24
Interventional
242 
Curcumin Docetaxel
Breast Neoplasm… Breast Cancer
The trial was stopped for futility in view of the results of the anticipated analysis
-
NCT03468777
2017-004832-12
Details
2018-07-23
Interventional
118 
Dexlansoprazole Lansoprazole Ranitidine Ranitidine bism…
Healthy
The study has been terminated due to pending data analysis
-
NCT02591888
Details
2018-07-23
Interventional
418 
Bupivacaine
Pain
Difficult to enroll; since a similar research project on a different population showed no significance the study has been closed.
-
NCT01041781
Details
2018-07-23
Interventional
3
[1 Refs]
313 
Carboplatin Celecoxib Gemcitabine Pemetrexed
Carcinoma, Non-… Lung Neoplasms Lung Cancer
DSMB recommendation
-
NCT03139500
2016-004085-26
Details
2018-07-20
Interventional
147 
Midazolam
Healthy
Terminated due to nonclinical findings
-
NCT03111069
Details
2018-07-20
Interventional
10 
Doxorubicin Liposomal doxor…
Fever Hyperthermia Neoplasms Rhabdomyosarcom… Sarcoma Malignant Neopl… Rhabdomyosarcom… Rhabdomyosarcom…
PI withdrew study
-
NCT03090269
2013-002996-16
Details
2018-07-20
Interventional
20 
Methylphenidate
Cocaine-Related… Substance-Relat…
feasibility reasons.
-
NCT01932541
Details
2018-07-20
Interventional
40 
Lurasidone Hydr…
Bipolar Disorde… Mania Bipolar I Bipolar II Bipolar Spectru…
On hold due to competing departmental studies
-
NCT01836549
Details
2018-07-20
Interventional
243 
Imetelstat Motesanib dipho…
Astrocytoma Brain Stem Neop… Ependymoma Glioblastoma Gliosarcoma Oligodendroglio… Anaplastic Astr… Anaplastic Epen… Astrocytoma, Gr… Brainstem Tumor… Giant Cell Glio…
Due to several intracranial hemorrhages and recommendation by the PBTC DSMB.
-
NCT00169104
Details
2018-07-20
Interventional
2/3
[1 Refs]
23 
Lenograstim Trastuzumab Vinorelbine
Breast Neoplasm… Metastatic Brea…
Closed due to achievement of primary study endpoint
-
NCT03275558
Details
2018-07-19
Interventional
10 
Axitinib Sunitinib
Glioblastoma Glioma Gliosarcoma Anaplastic Glio… Recurrent Gliob…
Study halted prior to enrollment of first participant. (It has been determined on 2018 May 15 that the NCT03275558 study will be stopped by sponsor decision)
-
NCT02439944
Details
2018-07-19
Interventional
2/318 
Nicotine
Tobacco Use Dis… Nicotine Depend…
full RCT funded. no need to continue pilot data collection.
-
NCT00488384
Details
2018-07-19
Interventional
40 
Acitretin
Carcinoma, Squa…
lack of subjects
-
NCT03326258
Details
2018-07-18
Interventional
1/20 
Antibodies Antibodies, Mon… Glembatumumab v… Immunoconjugate… Immunoglobulins Immunotoxins Ipilimumab Nivolumab
Breast Neoplasm… Melanoma Melanoma, Cutan… Neoplasms Skin Neoplasms Uveal Neoplasms Advanced Malign… Estrogen Recept… GPNMB Positive HER2/Neu Negati… Metastatic Mali… Metastatic Mela… Progesterone Re… Stage III Breas… Stage III Cutan… Stage III Uveal… Stage IIIA Cuta… Stage IIIB Cuta… Stage IIIC Cuta… Stage IV Breast… Stage IV Cutane… Stage IV Uveal … Triple-Negative… Unresectable So…
The study itself was Disapproved on 04/20/2018 and will not be moving forward.
-
NCT03172741
Details
2018-07-18
Interventional
2/30 
Cannabidiol Dronabinol
Multiple Sclero… Sclerosis
Did not pursue study
-
NCT02540928
Details
2018-07-18
Interventional
235 
N-(1-(7-fluoro-…
Carcinoma Carcinoma, Squa… Squamous Cell C… Human Papilloma… Positive or Neg…
Safety Reasons
-
NCT01739556
Details
2018-07-18
Interventional
3242 
Aspirin Ticagrelor
Infarction Myocardial Infa… ST Elevation My… Acute ST-elevat…
An interim analysis showed that there is no difference in the primary endpoint, given the small number of events in the groups examined.
-
NCT00531986
Details
2018-07-18
Interventional
460 
Lopinavir
HIV Infections
Unexpectedely high rates of treatment-failure
-