Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

Filter:

Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
Free Text
Annotations

7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02486796
Details
2018-08-01
Interventional
1/25 
Coenzyme Q10 Melatonin Ubiquinone
Quality of Life
Operational barriers prevent critical specimen analyses from being performed.
-
NCT02365233
Details
2018-07-31
Interventional
45 
Dipeptidyl-Pept… Insulin Insulin Glargin… Insulin, Globin… Pioglitazone Saxagliptin Sitagliptin Pho…
Diabetes Mellit… Diabetes Mellit… Fatty Liver Non-alcoholic F… Nonalcoholic Fa… Type II Diabete…
IRB withheld the data due to inadequate supporting documentation
Inadequate documentation and lack of funding resulted in no usable data. IRB withheld the data.
NCT00626574
Details
2018-07-31
Interventional
43 
Epoetin Alfa
Hemorrhage Subarachnoid He…
This study is terminated as a result of data from a study that showed increased mortality in stroke patients.
In late October 2008, we received a letter from the sponsor requesting that we terminate any further work on this study.
NCT02914327
Details
2018-07-30
Interventional
10 
Ibrutinib
Cancer
Lack of enrollment
-
NCT02316847
Details
2018-07-30
Interventional
2126 
Diazepam
Epilepsy
-
-
NCT01935947
NCT01846897
Details
2018-07-27
Interventional
217 
Azacitidine Camptothecin Docetaxel Entinostat Gemcitabine Histone Deacety… Irinotecan Pemetrexed
Carcinoma, Non-… Lung Neoplasms Recurrent Non-S… Stage IIIA Non-… Stage IIIB Non-… Stage IV Non-Sm…
-
Low recruitment lead to slow accrual. Not having enough patients on the trial and high disease progression lead to closing the study.
NCT03207542
Details
2018-07-26
Interventional
20 
Daratumumab
Leukemia Leukemia, Lymph… Neoplasms Precursor Cell … Malignant Neopl…
PI request
-
NCT02893826
Details
2018-07-26
Interventional
16 
Nimodipine
Hemorrhage Subarachnoid He… Subarachnoid He…
Based on DMC recommendation to discontinue EG-01-1962-03
-
NCT02790632
Details
2018-07-26
Interventional
3-
Nimodipine
Hemorrhage Subarachnoid He… Subarachnoid He…
DMC review concluded study has a low probability of meeting its primary endpoint
-
NCT02737124
Details
2018-07-26
Interventional
30 
Acetaminophen
Pain, Postopera… Post Operative …
Study is currently Lapsed
-
NCT02621515
Details
2018-07-26
Interventional
27 
Nivolumab
Brain Neoplasms Melanoma Neoplasm Metast… Brain Metastasi…
In the Netherlands we wanted to add pilimumab to nivolumab. This resulted in a very long METC procedure which resulted in a to slow inclusion rate.
-
NCT02386111
Details
2018-07-26
Interventional
117 
Sunitinib
Carcinoma Carcinoma, Rena… Kidney Diseases Kidney Neoplasm… Neoplasms Neoplasms by Hi… Urogenital Neop… Urologic Diseas… Urologic Neopla… Clear-cell Meta…
Portfolio re-prioritization
-
NCT02277132
Details
2018-07-26
Interventional
2/3216 
Sildenafil Citr…
Fetal Growth Re… Fetal Growth Re…
Results of interim analysis
-
NCT02241551
Details
2018-07-26
Interventional
22 
Fluorouracil Gemcitabine Irinotecan Oxaliplatin Paclitaxel
Pancreatic Neop… Borderline Rese…
Study was terminated with the IRB ended early as logistical concerns of the SBRT
-
NCT01830270
Details
2018-07-26
Interventional
2
[1 Refs]
30 
Epirubicin Paclitaxel
Esophageal Neop… Stomach Neoplas… Lower Oesophagu… Oesophageal Jun…
-
-
NCT01654861
Details
2018-07-26
Interventional
13 
Ascorbic Acid Gemcitabine
Adenocarcinoma Metastatic Aden…
recruiting or enrolling participants has halted prematurely and will not resume
-
NCT01591473
Details
2018-07-26
Interventional
1/2
[1 Refs]
55 
Poly I-C poly(I).poly(c1…
Influenza, Huma…
The CDC indicated nasal spray flu vaccine should not be used during 2016-2017
-
NCT01477853
2011-003600-20
Details
2018-07-26
Interventional
3166 
Atorvastatin Glimepiride Metformin Sitagliptin Pho…
Diabetes Mellit… Diabetes Mellit… Type 2 Diabetes…
The study was terminated early by the Sponsor for business reasons.
The study was terminated early by the Sponsor for business reasons. Due to the small number of participants included in the FAS, the results for Phase A and for the overall study should be interpreted with caution.
NCT02095717
2013-002138-20
Details
2018-07-24
Interventional
250 
Curcumin Docetaxel
Prostatic Neopl… Prostate Cancer…
The trial was stopped for futility in view of the results of the interim analysis
-
NCT02066649
Details
2018-07-24
Interventional
30 
Carvedilol
Hypertension Hypertension, P… Portal Hyperten…
We need to revise and redesign the study
-