Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02721875
2015-004490-32
Details
2018-08-09
Interventional
11 
Azacitidine
Myelodysplastic… Preleukemia Syndrome
-
Trial was prematurely discontinued and only one patient was treated. So it was not possible to draw any conclusion about volasertib monotherapy/with azacitidine, in patients with Myelodysplastic syndrome after Hypomethylating agent treatment failure
NCT01923311
2013-001969-16
Details
2018-08-09
Interventional
2/331 
Elvitegravir
Acquired Immuno… HIV Infections Immunologic Def… Acquired Immune…
-
-
NCT00012298
NCT01646879
Details
2018-08-09
Interventional
1/281 
Antibodies, Mon… Oprelvekin Rituximab
Leukemia, Lymph… Lymphoma Lymphoma, B-Cel… Lymphoma, B-Cel… Lymphoma, Folli… Lymphoma, Non-H… Recurrence Waldenstrom Mac… Extranodal Marg… Nodal Marginal … Recurrent Grade… Recurrent Grade… Recurrent Grade… Recurrent Margi… Recurrent Small… Splenic Margina… Waldenström Ma…
Trial completed prematurely.
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NCT02585765
Details
2018-08-08
Interventional
20 
Pioglitazone
Pressure Ulcer Spinal Cord Inj… Ulcer Pressure Ulcers Spinal Cord Inj…
an alternate plan of investigation was developed.
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NCT01636960
Details
2018-08-08
Interventional
1
[1 Refs]
9 
Peginterferon a…
Melanoma Malignant Melan…
The study was terminated after 118 weeks from the study start, during the maintenance phase, due to regulatory approval in Japan.
The study was terminated after 118 weeks from the study start, during the maintenance phase, due to regulatory approval in Japan.
NCT02734940
Details
2018-08-07
Interventional
43 
Dexmedetomidine Fentanyl Ketamine Lidocaine Morphine
Heart Diseases
Unable to find participants who met inclusion/exclusion criteria
-
NCT02011126
Details
2018-08-07
Interventional
20 
Imetelstat Motesanib dipho…
Hepatoblastoma Neuroblastoma Neuroectodermal… Neuroectodermal… Neuroectodermal… Osteosarcoma Recurrence Rhabdomyosarcom… Rhabdomyosarcom… Sarcoma, Ewing Previously Trea… Recurrent Child… Recurrent Child… Recurrent Ewing… Recurrent Neuro… Recurrent Osteo…
IND no longer available.
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NCT01795976
Details
2018-08-07
Interventional
22 
Cyclophosphamid… Fludarabine Interleukin-2
Oesophageal Can…
Withdrawal of funding
-
NCT00899678
2014-004381-24
Details
2018-08-07
Interventional
299 
Certolizumab Pe…
Crohn Disease Crohn's Disease
higher than projected discontinuation rate during Maintenance Phase
-
NCT00728585
Details
2018-08-07
Interventional
20 
Mitogens
Mucositis Neoplasms Stomatitis Gastrointestina… Malignant Neopl…
Withdrawn
-
NCT00278564
Details
2018-08-06
Interventional
17 
Cyclophosphamid… Methylprednisol… Methylprednisol… Methylprednisol… Prednisolone Prednisolone ac… Prednisolone he… Prednisolone ph… Rituximab
Muscular Diseas… Myositis MYOPATHY
high relapse rate
Early termination leading to small numbers of subjects analyzed
NCT03465345
Details
2018-08-03
Interventional
10 
Metformin Proanthocyanidi… Procyanidin
Prostatic Neopl… Prostate Cancer
Study was stopped to pursue a new treatment plan with a new study.
-
NCT03196401
Details
2018-08-03
Interventional
10 
Durvalumab
Plasmacytoma Solitary Bone P…
FDA recommendation
-
NCT02363946
2015-001147-36
Details
2018-08-03
Interventional
165 
Diphenhydramine Promethazine
Alpha 1-Antitry… Alpha-1 Antitry…
Company decision to terminate the trial
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NCT01445392
NCT00575770
Details
2018-08-03
Interventional
124 
Antibodies, Mon… Pemetrexed
Mesothelioma Mesothelioma, M…
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NCT02846766
Details
2018-08-02
Interventional
20 
Lenvatinib
Cancer
Unable to execute a contract agreement with the drug manufacturer.
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NCT01755520
2012-003630-16
Details
2018-08-02
Interventional
31893 
Aspirin Ticagrelor
Acute Coronary … Angina, Stable Coronary Artery… Stable Angina
DSMB Interim Analyses
-
NCT00200382
Details
2018-08-02
Interventional
2-
Bortezomib
Carcinoma, Non-… Lung Neoplasms Non-small Cell …
The study did not achieve the statistical success to continue.
-
NCT03370159
Details
2018-08-01
Interventional
1/20 
Docetaxel Thioctic Acid
Carcinoma, Non-… Lung Neoplasms Stage IIIB Non-… Stage IV Non-Sm…
Sponsor decided not to move forward
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NCT03297463
Details
2018-08-01
Interventional
1/20 
Interleukin-2 Ipilimumab
Brain Neoplasms Melanoma Neoplasm Metast… Brain Metastase… Hepatic Metasta… Metastatic Mela… Pulmonary Metas…
Replaced by another study.
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