Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01613469
Details
2018-08-16
Interventional
25 
Leucovorin
Rectal Neoplasm…
Re-eval of patient population
-
NCT01294683
2010-023939-42
Details
2018-08-16
Interventional
3977 
Niacin Niacinamide Nicotinic Acids Simvastatin
Dyslipidemias Hypercholestero… Dyslipidemia Primary Hyperch…
-
-
NCT01274559
Details
2018-08-16
Interventional
31173 
Niacin
Dyslipidemias Hypercholestero… Mixed Dyslipide… Primary Hyperch…
In HPS2-THRIVE, MK-0524A did not meet the primary efficacy objective and there was a significant increase in incidence of some types of non-fatal SAEs
MK-0524A-133 was stopped prior to completion. Raw individual efficacy data were obtained but none of planned efficacy outcomes were summarized or analyzed. Only safety data were summarized.
NCT01243762
Details
2018-08-16
Interventional
1
[1 Refs]
47 
3-(4-((4-chloro…
Neoplasms Neoplasms Malig…
The study was terminated for business reasons and not due to any safety or efficacy concerns related to dalotuzumab.
The study was terminated for business reasons and not due to any safety or efficacy concerns related to dalotuzumab.
NCT00800137
Details
2018-08-15
Interventional
4
[1 Refs]
984 
Calcium heparin Dalteparin Heparin Heparin, Low-Mo… Tinzaparin Warfarin
Hematoma
At time of pre-specified 2nd interim analysis
-
NCT03377101
Details
2018-08-14
Interventional
20 
Fulvestrant Palbociclib
Breast Neoplasm… Estrogen Recept… HER2/Neu Negati… Progesterone Re… Stage IV Breast…
change in study design.
-
NCT03227432
Details
2018-08-14
Interventional
20 
Dexamethasone Elotuzumab Nivolumab Pomalidomide
Multiple Myelom… Neoplasms, Plas…
Withdrawn before enrollment due to issues around the FDA hold on PD-1/PD-L1 drugs in combination with IMIDs.
-
NCT03143530
Details
2018-08-14
Interventional
40 
Ropivacaine
Agnosia Analgesia, Post… Mastectomy Nerve Block
Extensive protocol revisions initiated.
-
NCT02351037
Details
2018-08-14
Interventional
236 
Azacitidine Ibrutinib
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
Study data do not support development in AML.
-
NCT01911325
2013-000833-11
Details
2018-08-14
Interventional
127 
Docetaxel
Carcinoma, Non-… Lung Neoplasms Squamous Non-sm…
Review of safety and preliminary efficacy data showed marginal anti-tumor activity.
-
NCT01907802
NCT02925689
Details
2018-08-14
Interventional
18 
Dabrafenib
Renal Insuffici… BRAF Gene Mutat… Hepatic Complic… Renal Failure Solid Neoplasm
-
-
NCT03200080
Details
2018-08-13
Interventional
126 
Amphetamine Dextroamphetami…
Abuse Potential
New Safety Information
-
NCT01690325
Details
2018-08-13
Interventional
221 
Bevacizumab Cyclophosphamid… Docetaxel Epirubicin Trastuzumab
Breast Neoplasm… Breast Cancer
Therapy of HER2+ patients according to protocol was no longer appropriate. Patient enrolment behind planned schedule and challenges of site performance
-
NCT01648101
Details
2018-08-13
Interventional
376 
Ezogabine
Epilepsy Seizures
Registration of the medicine is no longer being pursued in South Korea, Taiwan or Vietnam
RTG114855 was designed for registration of retigabine as add-on treatment of drug-resistant POS in South Korea/Taiwan/ Vietnam. GSK decided not to pursue registration in these countries and terminated the study early based on new safety information.
NCT00950261
Details
2018-08-13
Interventional
20 
Cisplatin
Uterine Cervica… Cervical Neopla…
A competing trial has been initiated.
-
NCT00697034
Details
2018-08-13
Interventional
412 
Capsaicin
Psoriasis
Lack of qualified and willing volunteers.
-
NCT02672358
Details
2018-08-10
Interventional
20 
Dabrafenib Trametinib
Carcinoma, Non-… Lung Neoplasms Non-Small-Cell …
Company Decision
-
NCT02343263
Details
2018-08-10
Interventional
218 
Bupivacaine Fibrin Tissue A…
Hemorrhage Pain, Postopera… Postoperative H…
FDA IND was not obtained
study closed due to need for FDA investigational new drug application.
NCT00104806
Details
2018-08-10
Interventional
25 
Arsenic Trioxid… Cholecalciferol Vitamin D
Myelodysplastic… Myelodysplastic… Myeloproliferat… Preleukemia Syndrome Leukemia Myelodysplastic…
sponsor discontinues support
-
NCT03009058
Details
2018-08-09
Interventional
1/22 
Albumin-Bound P… Capecitabine Cetuximab Cyclophosphamid… Fluorouracil Folic Acid Gemcitabine Ipilimumab Irinotecan Leucovorin Levoleucovorin Nivolumab Oxaliplatin Pembrolizumab
Neoplasm Metast… Metastatic Canc…
Commercial reasons
-