Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02824913
Details
2018-08-31
Interventional
21 
Ophthalmic Solu… Pharmaceutical …
Dry Eye Syndrom… Eye Diseases Keratoconjuncti… Dry Eye Disease
-
-
NCT01842334
Details
2018-08-31
Interventional
1/222 
Nicotine
Tobacco Use Dis… Nicotine Depend… Smoking Cessati…
left institution protocol closed
Due to lack of sufficient funds/resources, the sample size for this study is not large enough to extract any conclusive results. The high number of subjects withdrawing from the study early also hinders any possible conclusions.
NCT01267825
Details
2018-08-31
Interventional
41 
Bupivacaine
Hernia Intervertebral … Radiculopathy Disc Herniation Lumbosacral Rad…
Study terminated early due to low enrollment. No data collected.
-
NCT01015677
Details
2018-08-31
Interventional
299 
Estradiol Estradiol 17 be… Estradiol 3-ben… Polyestradiol p…
Moderate to Sev… Women
-
The study was terminated at the end of Stage 1 so no participants entered Stage 2 and no participants received MK-6913 25 mg.
NCT01621243
Details
2018-08-29
Interventional
1/2128 
Albumin-Bound P… Gemcitabine Paclitaxel
Pancreatic Neop… Metastatic Panc…
The study was terminated after a pre-planned futility analyses showed an insufficient level of efficacy in the study population to warrant continuation.
-
NCT01534351
Details
2018-08-29
Interventional
31 
Finasteride Tamsulosin
Hyperplasia Prostatic Hyper… Benign Prostati…
Business Reasons
The trial was terminated for business reasons.
NCT00632970
Details
2018-08-29
Interventional
46 
Emtricitabine Emtricitabine, … Lopinavir Raltegravir Pot… Ritonavir Tenofovir
HIV Infections
no patients completed
-
NCT03182894
Details
2018-08-28
Interventional
1/20 
Azacitidine Pembrolizumab
Colorectal Neop… Metastatic Colo…
Study will not be conducted due to changes related to the investigational agent.
-
NCT02974114
Details
2018-08-28
Interventional
421 
Acetaminophen Caffeine
Pain
-
The study was terminated early due to breaches of GCP guidelines observed during a GSKCH internal audit. The minimum requirement of 8 subjects per strata was not met because of early termination so some exploratory analyses were not conducted.
NCT02397356
2014-000837-22
Details
2018-08-28
Interventional
40 
Ketamine
Pain, Postopera…
Lack of study personnel
-
NCT00804830
2007-001783-75
Details
2018-08-28
Interventional
215 
Bevacizumab Doxorubicin
Thyroid Carcino… Thyroid Disease… Thyroid Neoplas… Carcinoma Metastatic Canc… Thyroid Cancer
lack of response
-
NCT02864628
Details
2018-08-27
Interventional
10 
Smallpox and mo…
Respiratory Syn…
Protocol was withdrawn from IND
-
NCT01756105
Details
2018-08-27
Interventional
2-
Insulin Insulin, Isopha… Isophane Insuli… Isophane insuli… Metformin
Diabetes Mellit… Diabetes, Gesta… Gestational Dia… Metformin Oxidative Stres… Treatment
-
-
NCT01716234
2007-004645-15
Details
2018-08-27
Interventional
1142 
Posaconazole
Mycoses Fungal Infectio…
Study was terminated early (10 July 2015) based on preliminary analysis of pharmacokinetic data.
Only 1 participant was enrolled in the POS 12 TID 3 months to <2 years group, limiting conclusions that may be drawn for pharmacokinetics or safety.
NCT00960063
Details
2018-08-27
Interventional
14 
Cyclophosphamid… Doxorubicin Etoposide Ifosfamide Irinotecan Temozolomide Vincristine
Bone Neoplasms Kidney Neoplasm… Neoplasms Neuroblastoma Bone Cancer Kidney Tumor Solid Tumors
Study was terminated for business reasons.
-
NCT00907517
Details
2018-08-27
Interventional
124 
Cytarabine
Leukemia Leukemia, Lymph… Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Precursor Cell … Leukemia, Lymph… Leukemia, Lymph… Myelogenous Leu… Myelogenous Leu…
-
-
NCT00427297
Details
2018-08-27
Interventional
334 
Abacavir Didanosine Dideoxynucleosi… Efavirenz Lamivudine Lopinavir Nevirapine Ritonavir Stavudine Tenofovir Zidovudine
HIV Infections
There is no longer equipoise. DSMB recommended termination.
The study team suggested discontinuation of the trial and the DSMB concurred based on slow accrual and based on new data that emerged after the RCT was initiated which made the trial question less relevant.
NCT02483598
Details
2018-08-24
Interventional
4-
Buspirone
Gastric Bypass
Initial analysis of results warranted a study re-design and work on the study was suspended.
-
NCT01868906
2009-015852-11
Details
2018-08-24
Interventional
26 
Temozolomide
Glioma Malignant Gliom…
Isotope (FMISO) production is no longer available in our country.
-
NCT01678820
Details
2018-08-24
Interventional
3299 
Glimepiride Metformin Simvastatin Sitagliptin Pho…
Diabetes Mellit… Diabetes Mellit… Type 2 Diabetes…
Merck terminated the study for business reasons in November 2013.
Study was terminated for business reasons in November 2013.