Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03444649
Details
2018-09-11
Interventional
10 
Cytarabine Daunorubicin Idarubicin
AML
IMP will not be further developed
-
NCT01591902
Details
2018-09-11
Interventional
4129 
Tesamorelin
Diabetic Retino… Retinal Disease… HIV
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NCT00689390
2006-006529-25
Details
2018-09-11
Interventional
2/31954 
Peginterferon a… Ribavirin
Hepatitis Hepatitis A Hepatitis C Hepatitis C, Ch… Hepacivirus
The study was terminated due to satisfaction of post-marketing commitments
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NCT00621530
Details
2018-09-11
Interventional
262 
Ketorolac Ketorolac Trome…
Hypersensitivit… Hip Arthroplast…
Terminated due to discontinuation of Acular PF (investigational medication)
The trial was terminated because the study drug became unavailable.
NCT02492763
Details
2018-09-10
Interventional
2176 
Liraglutide Metformin
Diabetes Mellit… Diabetes Mellit… Type II Diabete…
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NCT02489500
Details
2018-09-10
Interventional
33 
Bortezomib Lenograstim Melphalan
Amyloidosis Immunoglobulin … AL Amyloidosis
Enrollment held for toxicity evaluation; then closed due to competing trial
Early termination after enrollment held for toxicity evaluation; then closed due to competing trial.
NCT02181387
Details
2018-09-10
Interventional
433 
Acetaminophen
Pain
funding and compounding issues
-
NCT02143141
Details
2018-09-10
Interventional
413 
Morphine
Pain, Postopera… Postoperative P… Scheduled Cesar… Side Effects
feasibility of population needed to complete study
Early termination leading to small number of subjects analyzed. Extreme difficulty in recruiting participants to participate in the study.
NCT02131272
2013-005500-33
Details
2018-09-10
Interventional
3
[1 Refs]
42 
Insulin Insulin Detemir Insulin, Globin… Insulin, Isopha… Isophane Insuli… Isophane insuli…
Diabetes Mellit… Diabetes Mellit… Diabetes
-
The trial was terminated earlier than planned due to a very slow recruitment rate. Based on the low number of subjects, the conclusions should be interpreted with caution.
NCT01863667
2013-000301-23
Details
2018-09-10
Interventional
365 
Glimepiride
Diabetes Mellit… Diabetes Mellit… Type 2 Diabetes…
-
The study was terminated based on business decisions only, and not due to any unexpected safety or efficacy concerns.
NCT00868790
Details
2018-09-10
Interventional
2118 
Metformin
Diabetes Mellit… Diabetes Mellit… Type 2 Diabetes…
Upon interim analysis, sufficient data was accrued to assess study hypotheses.
A pre-specified interim analysis of the efficacy and safety data for the initial cohort of participants in this study (Cohort 1) determined that sufficient data had been accrued to assess the study hypotheses, thus the study was discontinued.
NCT00322881
Details
2018-09-10
Interventional
2
[1 Refs]
12 
Carboplatin Paclitaxel
Fallopian Tube … Mixed Tumor, Me… Fallopian Tube … Ovarian Cancer Primary Periton…
Early closure based on audit by study investigators after 3 patients died on study.
This study terminated early due to 3 deaths on study and consequently results are limited.
NCT00693160
Details
2018-09-07
Interventional
230 
Capsaicin Ketorolac Remifentanil
Healthy
the manufacturing of preservative free ketorolac (Acular-PF) was discontinued
-
NCT00783172
Details
2018-09-06
Interventional
14 
Enkephalins Gemcitabine Mitogens
Pancreatic Neop… Pancreatic Canc…
Problems with IRB
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NCT02757287
Details
2018-09-05
Interventional
40 
Desogestrel
Infertility
Lack of financial support
-
NCT02650635
Details
2018-09-05
Interventional
14 
Cyclophosphamid… Lenograstim
Adenocarcinoma Breast Neoplasm… Carcinoma Carcinoma, Non-… Carcinoma, Rena… Colorectal Neop… Melanoma Melanoma, Cutan… Pancreatic Neop… Recurrence Colorectal Aden… Metastatic Panc… Recurrent Breas… Recurrent Color… Recurrent Melan… Recurrent Non-S… Recurrent Pancr… Recurrent Renal… Solid Neoplasm Stage IV Breast… Stage IV Non-Sm… Stage IV Renal … Stage IV Skin M… Stage IVA Color… Stage IVA Pancr… Stage IVB Color… Stage IVB Pancr…
permanently closed per sponsor's request
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NCT02093221
Details
2018-09-05
Interventional
276 
Alpha 1-Antitry… Protease Inhibi… Protein C Inhib…
Alpha 1-Antitry… Diabetes Mellit… Diabetes Mellit… Type 1 Diabetes…
Wk 52 primary endpoint results would be unaffected by follow-up data so trial was discontinued prior to wk 104. No safety data was collected after wk 52.
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NCT01104662
Details
2018-09-05
Interventional
492 
Cloxacillin Daptomycin Nafcillin Oxacillin Penicillins Vancomycin
Bacteremia Communicable Di… Infections Renal Insuffici… Skin Diseases, … Complicated Ski… Renal Impairmen… S. Aureus Bacte…
Cubist has reached an agreement with the FDA that enrollment in the DAP-RENSE-08-05 study can stop.
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NCT00039091
Details
2018-09-05
Interventional
126 
Antibodies Antibodies, Mon… Antineoplastic … Immunoglobulins Ipilimumab
Carcinoma, Non-… Carcinoma, Ovar… Leukemia Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Lung Neoplasms Melanoma Myelodysplastic… Myelodysplastic… Myeloproliferat… Preleukemia Recurrence Syndrome Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Atypical Chroni… Myelodysplastic… Previously Trea… Recurrent Adult… Recurrent Melan… Recurrent Non-s… Recurrent Ovari… Stage IV Melano… Stage IV Non-sm…
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NCT03082300
Details
2018-08-31
Interventional
13 
Naquotinib
Carcinoma, Non-… Lung Neoplasms Epidermal Growt… Non-small Cell …
Following recommendation by SOLAR Study IDMC, Astellas closed enrollment in ASP8273 studies.
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