Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02415595
2013-005487-26
Details
2018-09-19
Interventional
2210 
BMS-955176
Acquired Immuno… HIV Infections Infection, Huma…
The trial ended early due to GI intolerability and treatment-emergent resistance.
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NCT00413959
Details
2018-09-19
Interventional
212 
Bortezomib Cyclophosphamid… Dexamethasone Rituximab
Lymphoma Lymphoma, B-Cel… Lymphoma, Non-H…
-
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NCT02495662
Details
2018-09-18
Interventional
230 
Methylprednisol… Methylprednisol… Methylprednisol… Prednisolone Prednisolone ac… Prednisolone he… Prednisolone ph…
Fistula Neointima Vascular Remode… Hemodynamics Renal Dialysis
Slow inclusion
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NCT01992562
Details
2018-09-18
Interventional
40 
Ziconotide
Bone Marrow Dis… Pain Spinal Cord Dis… Painful Myelopa… Painful Neuropa…
Logistical issues with study process and recruitment
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NCT03673605
Details
2018-09-17
Interventional
40 
Rivaroxaban Warfarin
Atrial Fibrilla… Constriction, P… Mitral Valve St…
No patients Enrollment
-
NCT03104998
Details
2018-09-17
Interventional
40 
Coenzyme Q10 Ubiquinone
Infertility Idiopathic Infe…
No further patient enrollment
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NCT01691872
Details
2018-09-17
Interventional
10 
Ezogabine
Epilepsies, Par… Epilepsy, Parti…
Development plan of retigabine XR in Japan was readjusted.
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NCT03504566
Details
2018-09-14
Interventional
40 
Empagliflozin Glucuronyl gluc… Linagliptin Telmisartan
Albuminuria Diabetic Nephro… Diabetic Nephro…
Registered and published incorrectly
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NCT03347461
Details
2018-09-14
Interventional
40 
Ciprofloxacin Dexamethasone
Otitis Media Otitis Media wi… Otitis Media Wi… Otorrhea
Low use of Otiprio among otolaryngologists.
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NCT02939846
Details
2018-09-14
Interventional
10 
Trametinib
Cancer
Change in strategy
-
NCT02447939
Details
2018-09-14
Interventional
10 
Dabrafenib Trametinib
Melanoma
Change in strategy
-
NCT01440595
2011-003299-36
Details
2018-09-14
Interventional
25 
Grazoprevir Peginterferon a… Ribavirin
Hepatitis Hepatitis A Hepatitis C Hepatitis C, Ch…
Preliminary results of MK-5172 PN003 (NCT01353911) suggested a possible dose relationship to elevated transaminase levels in treatment with grazoprevir.
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NCT03212807
Details
2018-09-13
Interventional
20 
Durvalumab Lenalidomide
Lymphoma EBV Related Non… Primary CNS Lym… Primary Testicu…
FDA Hold for Combination Studies using Imids and PD1/PDL1 Compounds
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NCT02462525
2014-002609-39
Details
2018-09-13
Interventional
174 
Dexamethasone Pomalidomide
Multiple Myelom… Neoplasms, Plas…
No Go decision for ABBV-838
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NCT02058407
Details
2018-09-13
Interventional
133 
Pharmaceutical …
Bronchiectasis
Drug related AEs observed upon repeat dosing that with longer treatment duration could become worse. Required action on some biomarkers not observed.
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NCT01656395
2012-000643-27
Details
2018-09-13
Interventional
2576 
Montelukast
Asthma
-
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NCT02487953
Details
2018-09-12
Interventional
20 
Nicotine
Tobacco Use Dis… Nicotine Depend…
Study design changed significantly; was submitted as a different protocol.
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NCT01272388
Details
2018-09-12
Interventional
41 
Tadalafil
Aortic Valve St… Constriction, P… Aortic Stenosis
We designed a different pilot trial based on data obtained after this study started - the 2 studies were too overlapping to continue both.
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NCT00934661
Details
2018-09-12
Interventional
440 
Morphine
Hip Arthroplast…
Drug was discontinued by manufacturer
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NCT03491579
Details
2018-09-11
Interventional
10 
Cladribine Cytarabine
Recurrence AML Relapse
IMP will not be further developed
-