Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00670046
Details
2018-09-28
Interventional
215 
Valproic Acid
Prostatic Neopl… Prostate Cancer
The study was terminated per the PI decision.
The study was designed to have power with 15 patients in each arm. The study was closed before we reached the target as the PI changed institution.
NCT02506985
Details
2018-09-27
Interventional
410 
Rivaroxaban Warfarin
Embolism Pulmonary Embol… Thrombosis Venous Thrombos…
-
-
NCT03091439
Details
2018-09-26
Interventional
21 
Dalbavancin
Osteomyelitis
Business decision outlined by the corporation.
-
NCT02985840
Details
2018-09-26
Interventional
4127 
Dexamethasone Ondansetron
Abdominal Pain Emergencies Nausea
Unable to access EMR for patients enrolled prior to 8/2015 for data collection
Due to the transfer of electronic medical record systems, investigators were unable to access data from patients who were enrolled prior to August 2015 for the retrospective chart review component of this study.
NCT02012959
2013-002005-59
Details
2018-09-26
Interventional
39 
Tolvaptan
Hyponatremia
Issues with participant recruitment & enrollment which made the trial impossible or highly impracticable. Trial termination was not due to safety reasons.
Issues with recruitment and enrollment made trial execution highly impracticable. This ultimately led to termination of the trial. The study was not terminated due to safety reasons.
NCT00939549
Details
2018-09-26
Interventional
20 
(T,G)-A-L Cyclophosphamid… Glatiramer Acet…
Multiple Sclero… Multiple Sclero… Sclerosis Relapsing Remit…
Study revised to retrospective chart review
-
NCT02928419
Details
2018-09-25
Interventional
22 
Lenalidomide
Myelodysplastic… Preleukemia Syndrome
"the study has been closed due to a low rate of patient enrollment (2 patients since the start of the trial)"
-
NCT02797522
Details
2018-09-25
Interventional
147 
Acetaminophen Entecavir Histamine Antag… Histamine H1 An… Tenofovir
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch…
Company decision to discontinue trial
The ARC-521 Injection development program was terminated early for regulatory and business reasons secondary to findings occurring in a non-clinical toxicology study. Program termination was not due to safety findings in humans.
NCT02680847
Details
2018-09-25
Interventional
432 
Naltrexone Oxycodone
Moderate-severe…
The trial was terminated on 08FEB2018. Pfizer has decided to withdraw the New Drug Application and has notified FDA. There are no efficacy or safety concerns.
The study was terminated due to sponsor's decision instead of safety or efficacy reasons. Early termination led to small numbers of participants summarized or described and PK samples were not analyzed.
NCT00818259
Details
2018-09-25
Interventional
1
[1 Refs]
92 
Aprepitant Dexamethasone Fosaprepitant Ondansetron
Vomiting Chemotherapy-In…
Study terminated early prior to completing targeted enrollment of participants <6 months of age due to recruitment challenges.
-
NCT03346538
Details
2018-09-24
Interventional
217 
Edaravone
Cerebral Infarc… Ischemia Ischemic Stroke Stroke Acute Ischemic …
Business objectives have changed.
-
NCT03680976
Details
2018-09-21
Interventional
20 
CXA-10
Asthma
The study will not take place at the University of Pittsburgh
-
NCT02074904
Details
2018-09-21
Interventional
21 
Topiramate
Alcohol Drinkin…
We terminated the study to run it as a sub-study of NCT02371889, which is a 13 week, placebo controlled, double-blind, trial of topiramate in heavy drinkers.
We terminated the study to run it as a sub-study of NCT02371889. We didn't enter results of the one subject randomized to study medication due to privacy concerns.
NCT01121536
2009-016648-38
Details
2018-09-21
Interventional
3867 
Modafinil
Depression Depressive Diso…
Business decision related to efficacy rather than tolerability limitations, not stopped for any safety reasons.
-
NCT00527943
2006-002809-31
Details
2018-09-21
Interventional
3
[2 Refs]
12944 
Vorapaxar
Acute Coronary … Atherosclerosis Infarction Myocardial Infa… Myocardial Isch…
The trial was terminated at the request of the Data and Safety Monitoring Board.
Prior to the planned study completion, the Data Safety Monitoring Board recommended that all participants stop treatment and that the study be closed-out. The protocol-defined target number of primary efficacy endpoints had been reached by this time.
NCT03385057
Details
2018-09-20
Interventional
10 
Acetaminophen Ibuprofen
Hemorrhage Tonsillectomy W…
Study design flaws; research design needed to be reconfigured
-
NCT02688907
Details
2018-09-20
Interventional
27 
Adavosertib
Lung Neoplasms Small Cell Lung… Small Cell Lung…
change regimen
-
NCT02415608
Details
2018-09-20
Interventional
24 
Ibrutinib
Leukemia, Mast-… Mastocytosis Mastocytosis, S… Aggressive Syst… Mast Cell Leuke… Systemic Mastoc…
Slow accrual
-
NCT01164098
Details
2018-09-20
Interventional
330 
Rituximab
Proteinuria Recurrence FSGS
Voluntarily terminated by PI due to lack of feasibility.
-
NCT02551731
Details
2018-09-19
Interventional
29 
Cannabidiol
Spasm Spasms, Infanti…
Sponsor elected not to continue with study
-