Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03399435
2016-003958-33
Details
2018-10-11
Interventional
1242 
Bupivacaine Epinephrine Epinephryl bora… Neosaxitoxin Racepinephrine
Analgesia Anesthesia Anesthesia, Loc…
The sponsor decided to stop further dosing of healthy volunteers after reviewing the obtained efficacy data. The decision is not related to any safety concern.
-
NCT02831387
Details
2018-10-11
Interventional
247 
Ophthalmic Solu… Pharmaceutical …
Dry Eye Syndrom… Eye Diseases Keratoconjuncti… Dry Eye Disease
-
-
NCT02780700
Details
2018-10-11
Interventional
21 
Capecitabine Nintedanib
Colorectal Neop…
Substance discontinued
Trial was terminated prematurely because it was determined that nintedanib monotherapy demonstrated lack of efficacy in this indication in pivotal Phase III trial (LUME-Colon 1) that was ongoing at the time of the initiation of this trial.
NCT02055924
Details
2018-10-11
Interventional
185 
Ibrutinib
Lymphoma Lymphoma, B-Cel… B-cell Lymphoma
ANSM decision due to veino occlusive disease (security alert)
-
NCT01820325
2012-005541-21
Details
2018-10-11
Interventional
16 
Carboplatin Paclitaxel
Carcinoma, Non-… Lung Neoplasms Non-Small Cell …
Due to DLTs/AEs safety profile considered challenging.
-
NCT00090779
Details
2018-10-11
Interventional
2
[2 Refs]
130 
Emtricitabine Emtricitabine, … Lopinavir Ritonavir Tenofovir
HIV Infections
The DSMB concluded that the findings regarding the primary analysis would persist and that no additional study goals would be achieved by continuing the study.
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NCT03698045
Details
2018-10-10
Interventional
10 
Ophthalmic Solu…
Conjunctivitis Conjunctivitis,…
the clinical study was canceled by the sponsor due to logistics and programming
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NCT03496519
Details
2018-10-09
Interventional
10 
Antibodies, Mon… Durvalumab Trabectedin
Neoplasms Solid Tumor, Ad…
Contract Issues
-
NCT03340558
Details
2018-10-09
Interventional
20 
Atezolizumab
Colorectal Neop… Metastatic Colo…
Negative results in a similar study
-
NCT03310567
Details
2018-10-09
Interventional
20 
Pembrolizumab
Carcinoma Endometrial Neo… Recurrence Recurrent/ Meta…
Sponsors pulled out of the study
-
NCT02434549
Details
2018-10-09
Interventional
216 
abobotulinumtox…
Cerebral Palsy Muscle Spastici… Paralysis Cerebral Palsy,… Pain
Based on efficacy results from interim analysis
-
NCT01667107
2012-003140-68
Details
2018-10-09
Interventional
426 
Posaconazole
Mycoses Fungal Infectio…
Study terminated due to an unfavorable risk-benefit analysis
-
NCT02565147
2012-002314-39
Details
2018-10-05
Interventional
378 
Bivalirudin Heparin
Infarction Myocardial Infa… Acute Myocardia…
Futility at the interim analysis.
Since the measured difference in infarct size at Day 5 (by CMR) was <18%, the study was terminated for futility at the interim analysis as pre-defined in the protocol.
NCT02794714
Details
2018-10-04
Interventional
40 
Rocuronium
Neuromuscular B…
unresolved budget issues
-
NCT00975104
Details
2018-10-04
Interventional
20 
Immunoglobulin …
Age-associated …
Amgen has chosen at this time not to continue with AMG 745 study 20080733
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NCT02960503
Details
2018-10-02
Interventional
1/20 
Azithromycin
Anemia, Sickle … Sickle Cell Dis…
Key personnel moved to new location. Therefore, we had insufficient resources to initiate the trial.
-
NCT02580708
Details
2018-10-02
Interventional
1/27 
Trametinib
Carcinoma, Non-… Lung Neoplasms Non-small Cell …
Discontinued development of rociletinib in NSCLC. Stopped enrollment of new patients into all studies involving rociletinib.
-
NCT01657240
Details
2018-10-02
Interventional
30 
Olopatadine Hyd… Ophthalmic Solu… Pharmaceutical …
Conjunctivitis Conjunctivitis,… Allergic Conjun…
Formula Reformulation
-
NCT01541904
Details
2018-10-02
Interventional
20 
Ophthalmic Solu… Pharmaceutical …
Conjunctivitis Conjunctivitis,… Ocular Allergy Ocular Itching Perennial Aller… Seasonal Allerg…
Reformulation
-
NCT02769702
Details
2018-10-01
Interventional
42 
Adrenocorticotr…
Iridocyclitis Uveitis Uveitis, Anteri…
-
This study was prematurely terminated, only 2 participants enrolled. Although results are reported they should be interpreted with caution due to small sample size.