Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

Filter:

Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
Free Text
Annotations

7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03151811
Details
2024-01-30
Interventional
3495 
Dexamethasone Dexamethasone a… Melphalan Pomalidomide
Multiple Myelom… Neoplasms, Plas…
Sponsor assessed all endpoints and collected Overall Survival data for another two years following the primary completion date of 03Feb2021.
-
NCT01996696
Details
2024-01-30
Interventional
283 
Metformin
Adenocarcinoma Metabolic Syndr… Prostatic Neopl… Weight Gain Prostatic Neopl…
Results of interim analysis indicate no statistically significant difference in the primary objective between the two arms at baseline and 12 months of follow-up.
-
NCT01311713
2010-023657-12
Details
2024-01-30
Interventional
1/245 
Poly(ADP-ribose…
Neoplasms Solid Tumors
-
The study was terminated due to the reasons which are related to the pharmaceutical properties of the compound and not related to any safety concerns.
NCT01260870
Details
2024-01-30
Interventional
244 
Paclitaxel
Chronic Limb-Th… Ischemia Infrapopliteal … PAD
Bayer terminated the program and sold the IP to Medronic
-
NCT00659776
Details
2024-01-30
Interventional
2255 
Ferrosoferric O…
Inflammation Nervous System … Diagnostic Imag…
Due to staffing shortages and lack of funding during Covid.
-
NCT05176925
Details
2024-01-29
Interventional
25 
Tislelizumab
Carcinoma, Non-… Non-small Cell …
The trial was terminated per sponsor recommendation
-
NCT04869943
Details
2024-01-26
Interventional
352 
Exemestane
Breast Neoplasm… Metastatic Brea…
Business decision
-
NCT06007508
Details
2024-01-25
Interventional
28 
Insulin Glargin…
Diabetic Ketoac… Ketosis DKA
Study intervention was adopted as standard of care.
-
NCT03075527
Details
2024-01-25
Interventional
219 
Durvalumab Tremelimumab
Mesothelioma Mesothelioma, M…
Criteria not met for second stage at time of interim analysis
-
NCT05344625
Details
2024-01-24
Interventional
10 
Ketamine
Anxiety Disorde… Depression Cancer-related … Depressive Symp…
Study team is not moving forward with protocol
-
NCT05331131
Details
2024-01-24
Interventional
20 
Ketamine
Head and Neck N… Mucositis Stomatitis Cancer of Head … Mucositis Oral Pharyngeal Muco…
Study team not moving forward with protocol
-
NCT05173831
Details
2024-01-24
Interventional
20 
N-Methyl-3,4-me…
PTSD
Transfer of Sponsorship
-
NCT04968938
Details
2024-01-24
Interventional
20 
N-Methyl-3,4-me…
Stress Disorder… Stress Disorder… Posttraumatic S…
Sponsor decided not to pursue the study. Study ended prior to study start.
-
NCT04160091
Details
2024-01-24
Interventional
219 
FX006
Bursitis Osteoarthritis Adhesive Capsul… Osteoarthritis …
The study was terminated prematurely due to the COVID-19 pandemic creating uncertainty impacting trial progress and costs.
This study was terminated early by the Sponsor due to the COVID-19 pandemic. Summary statistics were calculated for available data, but given that only approximately 8% of the planned study population had enrolled and there no conclusions can be drawn from this study.
NCT04025216
Details
2024-01-24
Interventional
116 
Cyclophosphamid… Fludarabine
Fallopian Tube … Multiple Myelom… Neoplasms, Plas… Triple Negative… Fallopian Tube … Non-Small Cell … Ovarian Cancer Pancreatic Duct… Triple Negative…
The sponsor finds the risk/benefit analysis unfavorable and has terminated the study.
-
NCT03793010
Details
2024-01-24
Interventional
370 
FX006
Osteoarthritis Osteoarthritis,…
By Sponsor due to occurrences of incomplete study drug administration
This study was terminated early by the Sponsor due to occurrences of incomplete study drug administration. Only 15% of the planned study population had enrolled and no statistical evaluations reported due to insufficient sample size.
NCT03761511
Details
2024-01-24
Interventional
20 
Niacin Niacinamide Nicotinic Acids
Ataxia Cerebellar Atax… Friedreich Atax…
Due to a temporary halt the recruitment start was delayed. A re-evaluation of the sponsor revealed, that the study is no longer feasible due to increased administrative and financial requirements.
-
NCT03584516
Details
2024-01-24
Interventional
2/3155 
Methylprednisol… Methylprednisol… Methylprednisol… Prednisolone Prednisolone ac… Prednisolone he… Prednisolone ph… Prednisone
Bronchiolitis O… Graft vs Host D… Chronic Graft-v…
The study was terminated due to insufficient efficacy to support moving into Part 2 of the study; there were no safety concerns that contributed to this decision.
-
NCT01894633
Details
2024-01-24
Interventional
273 
Chloroquine
Brain Neoplasms Neoplasm Metast… Brain Metastasi…
terminated
-
NCT01769222
Details
2024-01-24
Interventional
13 
Antibodies Antibodies, Mon… Antineoplastic … Immunoglobulins Ipilimumab
Burkitt Lymphom… Immunoblastic L… Intraocular Lym… Leukemia Leukemia, Hairy… Leukemia, Large… Leukemia, Lymph… Leukemia, T-Cel… Leukemia-Lympho… Lymphoma Lymphoma, B-Cel… Lymphoma, B-Cel… Lymphoma, Extra… Lymphoma, Folli… Lymphoma, Large… Lymphoma, Large… Lymphoma, Large… Lymphoma, Mantl… Lymphoma, Non-H… Lymphoma, T-Cel… Lymphoma, T-Cel… Lymphoma, T-Cel… Lymphomatoid Gr… Melanoma Mycoses Mycosis Fungoid… Plasmablastic L… Precursor Cell … Recurrence Sezary Syndrome Waldenstrom Mac… Adult Nasal Typ… Anaplastic Larg… Angioimmunoblas… Cutaneous B-cel… Extranodal Marg… Hepatosplenic T… Nodal Marginal … Peripheral T-ce… Recurrent Adult… Recurrent Adult… Recurrent Adult… Recurrent Adult… Recurrent Adult… Recurrent Adult… Recurrent Adult… Recurrent Adult… Recurrent Colon… Recurrent Cutan… Recurrent Grade… Recurrent Grade… Recurrent Grade… Recurrent Mantl… Recurrent Margi… Recurrent Melan… Recurrent Mycos… Recurrent Recta… Recurrent Small… Refractory Hair… Small Intestine… Splenic Margina… T-cell Large Gr… Testicular Lymp… Waldenström Ma…
Planned Future Study
-