Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00276744
Details
2018-10-24
Interventional
2249 
Capecitabine Cetuximab Docetaxel Erlotinib Hydro… Gemcitabine Irinotecan Mitomycin Mitomycins Sirolimus
Pancreatic Neop… Pancreatic Canc…
Because there was no longer an active laboratory component to this study.
-
NCT02972502
Details
2018-10-23
Interventional
466 
Diphenhydramine Haloperidol Haloperidol dec… Metoclopramide Promethazine
Emergencies Headache Migraine Disord… Headache, Migra…
PI lapsed institutional training
This study was terminated by the IRB due to PI lapse in required training. Outcomes data reported includes preliminary figures for n=49 patients. Data not collected from 11 patients.
NCT02500927
Details
2018-10-23
Interventional
231 
Naquotinib
Carcinoma, Non-… Lung Neoplasms EGFR-TKI-naïve…
Following recommendation by SOLAR Study IDMC, Astellas closed enrollment in ASP8273 studies.
-
NCT02929576
2016-000796-25
Details
2018-10-22
Interventional
30 
Paclitaxel
Breast Neoplasm… Triple Negative… Breast Cancer
Further understanding about the role of androgen signaling in TNBC was required
-
NCT02850744
Details
2018-10-19
Interventional
210 
Temozolomide
Glioblastoma Glioblastoma Mu…
-
-
NCT01185548
Details
2018-10-19
Interventional
14 
Tolbutamide
Lymphoma Advanced Cancer
Terminated based on safety results from another trial
-
NCT02739477
Details
2018-10-18
Interventional
22 
Favipiravir
Hemorrhagic Fev… Ebola Virus Sur…
End date of epidemic
-
NCT01917006
2013-001650-94
Details
2018-10-18
Interventional
259 
Botulinum Toxin… Botulinum Toxin… abobotulinumtox…
Premature Birth Premature Ejacu…
Strategic business decision was made to terminate the program. There were no safety concerns.
-
NCT01944969
2012-004169-42
Details
2018-10-17
Interventional
326 
Brexpiprazole
Depression Depressive Diso… Depressive Diso… Major Depressiv…
The study was terminated because the lead-in study (14571A) in elderly was terminated; see Detailed Description.
Because the study was terminated, few efficacy data were collected. These data have not been reported in accordance with the ICH E3 regarding abbreviated clinical study reports. Furthermore, no firm conclusions can be drawn regarding safety.
NCT00874939
Details
2018-10-17
Interventional
14 
Donepezil
Alzheimer Disea… Alzheimer's Dis… Dementia
-
-
NCT03707678
Details
2018-10-16
Interventional
20 
Albuterol
Asthma
After careful review of new data on GSK2245035, GlaxoSmithKline has decided to cancel this study.
-
NCT03020563
Details
2018-10-16
Interventional
40 
Bupivacaine
Fractures, Bone Clavicle Fractu…
no longer necessary
-
NCT02592629
Details
2018-10-16
Interventional
419 
Ethyl Chloride Lidocaine Triamcinolone Triamcinolone A…
Shoulder Pain
Lack of time to enroll due to additional responsibilities of the PI and research coordinator.
-
NCT02474407
Details
2018-10-16
Interventional
278 
Diazepam
Drug Resistant … Epilepsy Refractory Epil…
-
-
NCT02469415
Details
2018-10-16
Interventional
23 
Azacitidine Decitabine
Myelodysplastic… Preleukemia Leukemia
FDA Clinical Hold
-
NCT01602679
Details
2018-10-16
Interventional
112 
Progesterone
Female Reproduc…
Interim analysis suggested futility.
-
NCT03191383
2016-002733-30
Details
2018-10-15
Interventional
20 
Vaccines
Respiratory Syn…
Study was canceled due to instability of the PreF antigen during manufacturing. No safety concern has been identified in past or ongoing studies.
-
NCT02138812
Details
2018-10-12
Interventional
169 
Paclitaxel
Neoplasms Medical Oncolog…
As another Mps1 inhibitor was being developed in parallel, the strategic decision was to move forward with the development of the follow up compound only.
-
NCT01956474
Details
2018-10-12
Interventional
21324 
Riboflavin
Keratoconus
-
-
NCT00132730
Details
2018-10-12
Interventional
2604 
MK 0873
Lung Diseases Pulmonary Disea…
-
The extension studies were terminated based on data from the completed base study suggesting that MK-0873, at doses up to 2.5 mg per day, demonstrated no benefits versus placebo in lung function or symptoms in participants with COPD.