Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02767024
Details
2018-10-31
Interventional
40 
Dobutamine Furosemide Nitroprusside
Heart Failure Acute Heart Fai…
No patients enrolled
-
NCT01956604
2013-000815-26
2013-000815-26
Details
2018-10-31
Interventional
220 
Clonidine
Delirium
The inclusion rate was too low, due to the exclusion criteria.
-
NCT00963547
Details
2018-10-31
Interventional
1
[1 Refs]
33 
Lapatinib Trastuzumab
Neoplasms Advanced Solid … Breast Cancer
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NCT00043810
Details
2018-10-31
Interventional
1/23 
Busulfan Fludarabine Fludarabine pho… GEL protein, Ge…
Leukemia, Myelo… Leukemia, Myelo… Myelodysplastic… Acute Myelogeno… Myelodysplastic…
-
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NCT00041782
Details
2018-10-31
Interventional
226 
Dalteparin Heparin, Low-Mo… Tinzaparin
Thrombosis Venous Thrombos… Deep Vein Throm… Neoplasms
-
-
NCT00038805
Details
2018-10-31
Interventional
2/33 
Gemtuzumab
Leukemia Myelodysplastic… Precursor Cell … Preleukemia
-
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NCT02410551
Details
2018-10-30
Interventional
24 
Busulfan Fludarabine Fludarabine pho…
Myeloproliferat… Neoplasms Myeloproliferat…
-
-
NCT01655823
Details
2018-10-30
Interventional
2125 
Tetrodotoxin
Neuralgia Peripheral Nerv… Neuropathic Pai… Pain Peripheral Neur…
Interim analysis completed and decided to terminate and proceed to Phase 3 trial.
-
NCT00429169
Details
2018-10-30
Interventional
4
[1 Refs]
101 
Bupropion Paroxetine
Depression Depressive Diso… Suicide
Interim analysis showed differential treatment effects.
Significant dropout meant the number of subjects with analyzable data was smaller than the number enrolled. An interim analysis of this pilot study showed differential treatment effects so a decision was made to stop enrollment early.
NCT01817257
2012-004117-14
Details
2018-10-29
Interventional
2
[1 Refs]
2 
Dalteparin Enoxaparin Heparin Heparin, Low-Mo… Tinzaparin
Embolism Pulmonary Embol… Thromboembolism Thrombosis Venous Thromboe… Venous Thrombos… Cancer Deep Vein Throm… Pulmonary Embol…
Early findings showed trial was not feasible
-
NCT01347866
2011-001671-39
Details
2018-10-29
Interventional
1105 
Gedatolisib Irinotecan
Neoplasms Advanced Cancer
Refer to Detailed Description for documentaion of Termination Statement.
This study was terminated prematurely for strategic reasons based on an internal portfolio prioritization.
NCT03431272
Details
2018-10-25
Interventional
40 
Lifitegrast
Dry Eye Syndrom… Eye Diseases Keratoconjuncti… Contact Lens Dr…
no longer interest / resources to start study
-
NCT03414450
Details
2018-10-25
Interventional
10 
Dasatinib
Blast Crisis Leukemia Leukemia, Lymph… Leukemia, Myelo… Leukemia, Myelo… Precursor Cell … Chronic Myeloid… Chronic Myeloid… Ph+ Acute Lymph… Ph- Acute Lymph…
Withdrawal requested by D3
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NCT02266797
Details
2018-10-25
Interventional
34 
Dexamethasone
Deglutition Dis… Dysphagia After…
-
-
NCT01606800
Details
2018-10-25
Interventional
445 
Interferon alph… Peginterferon a… Ribavirin
Hepatitis Hepatitis A Hepatitis C Hepatitis C, Ch…
The trial was terminated due to change in new standard of therapy during the study period.
This Trial was prematurely terminated due to the availability of more promising treatment for HCV participants and the change in treatment guidelines, which will offer the patient a better treatment opportunity.
NCT00796510
Details
2018-10-25
Interventional
33 
Sildenafil Citr… Sitaxsentan
Familial Primar… Hypertension Hypertension, P… Pulmonary Arter… Pulmonary Hyper…
Safety Issue: The trial was prematurely terminated on Dec 9, 2010, due to safety concerns, specifically new emerging evidence of hepatic injury
Due to the premature termination only 3 participants were recruited into this study. No summarization or analysis was done.
NCT00254436
Details
2018-10-25
Interventional
350 
Epoetin Alfa
Gastrointestina… Rectal Neoplasm… Gastrointestina… Rectal Cancer
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NCT01821040
2011-002353-57
Details
2018-10-24
Interventional
362 
Prednisone
Giant Cell Arte… Polymyalgia Rhe…
-
-
NCT01777854
Details
2018-10-24
Interventional
46 
Omeprazole
Gastroesophagea… Laryngopharynge… Throat Pain
Lack of patient interest in the study.
-
NCT00947466
2008-002428-27
Details
2018-10-24
Interventional
1/225 
Buprenorphine
Mucositis Chemotherapy In… Mouth Pain
25 patients have been recruited and it was considered that further recruitment would add no extra PK information
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