Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02272686
Details
2018-12-05
Interventional
21 
Ibrutinib
Lymphoma Lymphoma, B-Cel…
Slow Accrual
-
NCT01188369
Details
2018-12-03
Interventional
420 
Simendan
Hypertrophy Hypertrophy, Le… Diastolic Dysfu… Left Ventricula…
Terminated prematurely due to high incidence of postoperative atrial fibrillation.
-
NCT01727843
Details
2018-11-30
Interventional
315 
Tranexamic Acid
Femoral Neck Fr… Fractures, Bone Postoperative H… Femoral Neck Fr…
-
-
NCT00657449
Details
2018-11-30
Interventional
445 
Rofecoxib Valdecoxib
Acute Pain Ankle Injuries Sprains and Str…
See termination reason in detailed description.
-
NCT00923247
NCT00863720
Details
2018-11-29
Interventional
1/2
[1 Refs]
22 
Bortezomib
Thyroid Disease… Thyroid Neoplas… Medullary Thyro…
Terminated due to slow accrual,primary endpoint reached & investigator left NIH.
-
NCT01293539
Details
2018-11-27
Interventional
210 
Melphalan
Retinoblastoma
IAC is now recognized as part of standard of care treatment options in the US.
-
NCT00621036
Details
2018-11-26
Interventional
20 
Antibodies Immunoglobulin … Immunoglobulins Immunoglobulins… Methotrexate Sargramostim Thiotepa
Central Nervous… Intestinal Neop… Lymphoma Lymphoprolifera… Nervous System … Brain and Centr… Lymphoprolifera… Small Intestine…
MyVax did not meet its primary endpoints
-
NCT03300362
Details
2018-11-23
Interventional
2862 
Vaccines
Influenza, Huma… Influenza
Change to recommended season flu vaccine in UK
-
NCT00760318
Details
2018-11-23
Interventional
217 
Levetiracetam
Dystonia Dystonic Disord… Torticollis Cervical Dyston…
Sponsor decided to stop enrollment to review data.
-
NCT00412841
Details
2018-11-23
Interventional
243 
Atorvastatin
Necrosis Osteonecrosis Avascular Necro…
-
-
NCT03438344
Details
2018-11-21
Interventional
20 
Vaccines
Leukemia Leukemia, Lymph… Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Lymphoma Myelodysplastic… Myeloproliferat… Precursor Cell … Accelerated Pha… Acute Lymphobla… Acute Myeloid L… Bone Marrow Tra… Chronic Lymphoc… Chronic Phase C… Hematopoietic C… Hodgkin Lymphom… Myelodysplastic… Myelofibrosis Myeloproliferat… Non-Hodgkin Lym…
PI Withdrawal
-
NCT02044822
2013-003314-41
Details
2018-11-19
Interventional
2102 
Idelalisib Rituximab
Leukemia Leukemia, Lymph… Leukemia, Lymph… B-cell Chronic …
-
Due to the early termination of the study, efficacy data were not available for all participants, and therefore the prespecified analyses were not conducted.
NCT01980888
2013-003313-17
Details
2018-11-19
Interventional
3311 
Bendamustine Hy… Idelalisib Rituximab
Leukemia Leukemia, Lymph… Leukemia, Lymph… Chronic Lymphoc…
-
The study was terminated in agreement with the FDA due to urgent safety measures. Due to early study termination, the prespecified efficacy analyses were not conducted. The PFS data presented are investigator assessments rather than IRC assessments.
NCT01980875
2013-004551-20
Details
2018-11-19
Interventional
357 
Chlorambucil Idelalisib Obinutuzumab
Leukemia Leukemia, Lymph… Leukemia, Lymph… Chronic Lymphoc…
-
The study was terminated in agreement with the FDA due to urgent safety measures. Complete data were not collected for any participant.
NCT02334527
Details
2018-11-16
Interventional
212 
Palbociclib
Carcinoma, Tran… Metastatic Urot…
Data from first 12 subjects-primary endpoint not met. Data analysis underway.
-
NCT01853982
Details
2018-11-16
Interventional
34 
Ceftolozane Ceftolozane, ta… Piperacillin Piperacillin, T… Tazobactam
Pneumonia Pneumonia, Vent… Ventilator-Asso…
Terminated to focus on a larger study within the clinical development program.
This study was electively terminated to focus on a larger registrational study, which was also part of the clinical development program for nosocomial pneumonia.
NCT01732926
2012-004034-42
Details
2018-11-16
Interventional
3475 
Bendamustine Hy… Idelalisib Rituximab
Lymphoma Lymphoma, Non-H… Indolent Non-Ho…
-
Due to the early termination of the study, efficacy data were not available for all participants, and therefore the prespecified analyses were not conducted.
NCT01732913
Details
2018-11-16
Interventional
3295 
Idelalisib Rituximab
Lymphoma Lymphoma, Non-H… Indolent Non-Ho…
-
Due to the early termination of the study, efficacy data were not available for all participants, and therefore the prespecified analyses were not conducted.
NCT01203930
Details
2018-11-16
Interventional
2105 
Idelalisib Rituximab
Leukemia Leukemia, Lymph… Leukemia, Lymph… Lymphoma Chronic Lymphoc… Small Lymphocyt…
-
-
NCT03693573
Details
2018-11-15
Interventional
30 
Atezolizumab Bevacizumab
Carcinoma Carcinoma, Rena… Renal Cell Carc…
In the context of the ongoing evaluation of our data, we have determined that there is no need to generate additional safety data at this time in the 1L mRCC pa
-