Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02614560
Details
2019-01-09
Interventional
1/214 
Fludarabine Melphalan
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
-
No patients were enrolled in Phase 2 due to study termination.
NCT02313909
2013-000768-27
Details
2019-01-09
Interventional
3
[3 Refs]
7213 
Aspirin Rivaroxaban
Embolic Stroke Embolism Stroke
Study halted early due to no efficacy improvement over aspirin at an interim analysis and very little chance of showing overall benefit if study were completed
Study terminated early due to no efficacy improvement over aspirin at the second interim analysis and very little chance of showing overall benefit if the study were completed.
NCT01891669
Details
2019-01-09
Interventional
126 
PF-06263507
Breast Neoplasm… Carcinoma, Non-… Neoplasms Ovarian Neoplas… Carcinoma, Non …
The study was terminated on June 23, 2015 due to the company's change in prioritization for the portfolio and is not due to any safety concerns.
This study was terminated prematurely before treatment in Part 2 started due to a business-related decision.
NCT02299635
2014-002286-30
Details
2019-01-08
Interventional
219 
Nirogacestat
Breast Neoplasm… Triple Negative…
The study was terminated on June 24th, 2015 due to change in strategy of PF-03084014 development. There were no safety/efficacy concerns behind the decision.
This study was terminated prematurely based on project re-prioritization by the Sponsor and was not due to any safety concerns or regulatory actions.
NCT02008006
2013-000076-16
Details
2019-01-08
Interventional
221 
Bendamustine Hy… Cytarabine Etoposide Melphalan
Lymphoma Lymphoma, Folli… Follicular Lymp…
Insufficient recruitment and unavailability of the treatment
-
NCT01925274
2013-002095-40
Details
2019-01-08
Interventional
219 
Cetuximab Gedatolisib Irinotecan
Colorectal Neop… Metastatic Colo…
Enrollment to the study was terminated on 11Nvo2014 due to slow recruitment. There were no safety or efficacy issues that contributed to this decision.
This study was terminated by sponsor due to strategic reasons and not due to any safety or efficacy concerns with treatment of PF-05212384.
NCT01457131
Details
2019-01-08
Interventional
12 
Cyclophosphamid… Fludarabine
Kidney Neoplasm… Melanoma Neoplasm Metast… Neoplasms Neoplasms, Seco… Metastatic Canc… Metastatic Mela… Metastatic Rena…
-
-
NCT01441414
2011-002190-33
Details
2019-01-08
Interventional
218 
Axitinib
Carcinoma Carcinoma, Rena… Metastatic Rena…
See termination reason in detailed description.
On 06 Nov 2012, based on Part I safety findings and due to strategic considerations, Pfizer decided not to open enrolment onto Part II of the study and terminated the study. For primary OM, AEs reported in ≥2 participants overall are presented.
NCT01420081
2011-003062-32
Details
2019-01-08
Interventional
267 
Gedatolisib
Endometrial Neo…
See termination reason in detailed description.
-
NCT01232556
2010-020147-12
Details
2019-01-08
Interventional
3338 
Bendamustine Hy… Gemcitabine Inotuzumab Ozog… Rituximab
Aggression Lymphoma Lymphoma, Non-H…
The study was terminated prematurely on May 16, 2013, for futility. No new or unexpected safety issues were identified.
Interpretation of the results is limited by the small number of subjects analyzed and follow-up period was shortened due to the early termination of the study. Adverse Events were calculated using the safety populations.
NCT02567279
Details
2019-01-07
Interventional
32 
Denosumab
Anorexia Anorexia Nervos…
Great difficulties were encountered during recruitment, for fear Denozumab. Only 2 patients have been included since the study start.
-
NCT03092765
Details
2019-01-04
Interventional
229 
Quetmolimab
Cholangitis Liver Cirrhosis… Primary Biliary…
Sponsor's decision (non-safety related)
-
NCT02605122
Details
2019-01-03
Interventional
2/397 
Amoxicillin Amoxicillin-Pot… Ampicillin Azithromycin Ceftriaxone Clavulanic Acid Clavulanic Acid… Erythromycin Erythromycin Es… Erythromycin Et… Erythromycin la… Erythromycin st… Solithromycin
Pneumonia Pneumonia, Bact… Community-acqui…
Development not proceeding
The study was discontinued early due to a company business decision. Study discontinuation was not related to safety or tolerability.
NCT02520518
Details
2019-01-03
Interventional
29 
Dapagliflozin
Body Weight Weight Loss
Designed a new modified/simplified protocol see NCT 03180489
-
NCT03063242
Details
2018-12-31
Interventional
24 
Sargramostim
Kidney Diseases Kidney Transpla…
Insufficient resources necessary for completion.
-
NCT01722292
2012-003174-83
Details
2018-12-28
Interventional
1/226 
Carboplatin Etoposide
Small Cell Lung…
Change in clinical strategy.
Due to strategic reasons, the Phase 2 portion was not initiated, and further clinical development was stopped.
NCT02050321
Details
2018-12-26
Interventional
22 
Acitretin Vemurafenib
Melanoma Malignant Melan…
Pharmaceutical company pulled support for the trial.
-
NCT03026023
Details
2018-12-20
Interventional
40 
Grazoprevir Ribavirin
Hepatitis Hepatitis C Cardiac Transpl…
moved forward with another protocol utilizing pan genotypic treatment once it became commercially available and FDA approved
-
NCT02646774
Details
2018-12-20
Interventional
443 
Micafungin
Aspergillosis Invasive Asperg…
Due to administrative reasons
-
NCT01982071
Details
2018-12-20
Interventional
459 
Micafungin
Candidemia Candidiasis Candidiasis, In…
Due to administrative reasons
-