Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03058094
Details
2019-02-04
Interventional
30 
Abivertinib Pemetrexed
Carcinoma, Non-… NSCLC
Considiering to change the Chemotherapy into Gefitinib
-
NCT02732938
2015-003767-11
Details
2019-02-04
Interventional
222 
Gemcitabine Paclitaxel
Adenocarcinoma Metastatic Panc…
Pfizer made a business-related decision on 04May2017 to terminate study based on change in portfolio prioritization, and is not due to safety or efficacy.
The study was terminated prematurely based on the company's change in prioritization for the portfolio and was not due to any safety concerns or regulatory interactions.
NCT01817699
Details
2019-02-04
Interventional
4161 
Cholecalciferol Vitamin D
Anemia Renal Insuffici… Renal Insuffici… Vitamin D Defic… Kidney Transpla…
The independent Data Monitoring Committee recommended an early termination.
-
NCT02258607
Details
2019-02-01
Interventional
121 
N-(cyanomethyl)… Trametinib
Carcinoma, Non-… Lung Neoplasms Relapsed Metast…
-
-
NCT02244489
Details
2019-02-01
Interventional
116 
Capecitabine N-(cyanomethyl)… Oxaliplatin
Adenocarcinoma Relapsed/Refrac…
-
-
NCT02206763
Details
2019-02-01
Interventional
111 
Erlotinib Hydro… N-(cyanomethyl)…
Carcinoma, Non-… EGFR Mutated EG…
-
-
NCT02162537
Details
2019-02-01
Interventional
395 
Bevacizumab Pemetrexed
Adenocarcinoma … Brain Neoplasms Carcinoma, Non-… Lung Neoplasms Neoplasm Metast… Adenocarcinoma … Cerebral Metast… Non-small Cell … Non-small Cell …
Slow inclusions due in part to a change in practices. The first chemotherapy become a standard for patients with NSCL with asymptomatic brain metastases.
-
NCT02143804
Details
2019-02-01
Interventional
20 
Molgramostim Sargramostim
Urinary Bladder… Bladder Cancer High Grade Non Muscle Inva…
Change in trial design
-
NCT02003573
2013-001752-36
Details
2019-01-31
Interventional
113 
Decitabine
Leukemia Leukemia, Myelo… Leukemia, Myelo…
-
This study was prematurely discontinued following the decision by the sponsor to discontinue the development of volasertib.
NCT02828124
Details
2019-01-30
Interventional
1/225 
Nivolumab
Carcinoma Carcinoma, Hepa… Hepatocellular …
Business objectives have changed
-
NCT01633060
2012-002571-34
Details
2019-01-30
Interventional
3432 
Fulvestrant
Breast Neoplasm… Metastatic Brea…
Novartis decided not to pursue further development of buparlisib program (assessment of moderate PFS benefit with know, but manageable, buparlisib profile).
The primary efficacy analysis was completed by 23May16 (primary PFS analysis cutoff date). The study was later terminated and the final safety analysis was conducted up to 08Sep17. One CRF was collecting on 21Sep2017 for survival follow up (LPLV).
NCT03779100
Details
2019-01-28
Interventional
2-
Antibodies Immunoglobulins Lenvatinib
Cholangiocarcin… Intrahepatic Ch…
Protocol modification
-
NCT03160729
Details
2019-01-28
Interventional
445 
Dexamethasone
Kidney Diseases Postoperative C…
Slow recruitment, schanges in standard treatment
-
NCT02606552
Details
2019-01-28
Interventional
49 
Aspirin Clopidogrel
Atrial Fibrilla… Coronary Artery… Coronary Diseas… Myocardial Isch…
The number of patients registered for the study was low and it was expected to be difficult to derive the study results.
-
NCT02373462
Details
2019-01-28
Interventional
41 
Antihypertensiv… Olmesartan
Intermittent Cl… Peripheral Arte… Peripheral Arte…
The data of the paper referenced in the preparation of the protocols in this task were manipulated and the paper was withdrawn.
-
NCT01372202
Details
2019-01-25
Interventional
231 
Fluorouracil Oxaliplatin Paclitaxel
Esophageal Neop… Esophageal Canc…
Study stopped due to early stopping rule
-
NCT02412475
Details
2019-01-24
Interventional
13 
Cytarabine Decitabine Fludarabine Sorafenib Vorinostat
Leukemia, Myelo… Leukemia, Acute…
We opened a competing study with the TACL consortium
-
NCT03079505
Details
2019-01-23
Interventional
310 
Dasatinib Nilotinib
Leukemia Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Chronic Myeloid…
Protocol Deviation
-
NCT02646800
Details
2019-01-23
Interventional
4105 
Micafungin
Aspergillosis Candidiasis Mycoses
Due to administrative reasons
-
NCT01185509
Details
2019-01-23
Interventional
231 
Trastuzumab Vinorelbine
Breast Neoplasm… Breast Cancer Metastatic Brea…
Not enough confirmed responses to continue treatment.
The study terminated early due to insufficient response per statistical design.