Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

Filter:

Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
Free Text
Annotations

7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01210378
Details
2019-02-15
Interventional
247 
Nitroglycerin
Carcinoma, Non-… Lung Neoplasms Non Small Cell …
Accrual stopped
-
NCT01003418
Details
2019-02-15
Interventional
28 
Heptavalent Pne…
Influenza, Huma… Influenza
The study was terminated prematurely for logistic reasons, not related to safety or efficacy of the vaccine.
-
NCT00917293
Details
2019-02-15
Interventional
253 
Pyridoxal Pyridoxal Phosp…
Dyskinesias Tardive Dyskine…
modified formulation under investigation
-
NCT03559387
Details
2019-02-12
Interventional
29 
Lenograstim
Neutropenia Chemotherapy-in…
Study redesign
-
NCT02588261
2015-002894-39
Details
2019-02-12
Interventional
3530 
Erlotinib Hydro… Gefitinib Naquotinib
Carcinoma, Non-… Lung Neoplasms Non-small Cell …
Following recommendation by SOLAR Study IDMC, Astellas closed enrollment in ASP8273 studies
-
NCT01403246
Details
2019-02-12
Interventional
1/29 
Chlorambucil Lenalidomide
Leukemia Leukemia, Lymph… Leukemia, Lymph… Chronic Lymphoc…
Slow patient enrollment and new molecules for chronic lymphoid leukemia, have importantly reduced the interest of conducting the phase II of this study.
-
NCT02346370
Details
2019-02-08
Interventional
116 
Docetaxel
Carcinoma, Non-… Lung Neoplasms Non-small Cell …
Changing standard of care therapy regimen
This study was discontinued early by the Sponsor during the Dose Escalation Period.
NCT01957644
2013-001290-24
Details
2019-02-08
Interventional
116 
Azacitidine
Leukemia Leukemia, Myelo… Myelodysplastic… Preleukemia Syndrome
-
The sponsor discontinued the development of volasertib on 25 Nov 2016 and this trial was discontinued on 16 Dec 2016 for non-clinical reasons. The number of patients enrolled in Part 2 of the study was too small for a meaningful analysis.
NCT02787798
Details
2019-02-07
Interventional
44 
Sacubitril and … Valsartan
Heart Failure
Today Entresto treatment has marketing authorization and is available for all patients, that is the reason why study was halted prematurely.
-
NCT02438761
Details
2019-02-06
Interventional
210 
Gedatolisib
Leukemia Leukemia, Myelo… Leukemia, Myelo… Myelodysplastic… Preleukemia Acute Myeloid L… Therapy-related… de Novo Acute M…
No objective response was observed at the first step. The treatment was considered ineffective, with a complete clinical trial suspension.
-
NCT01335997
2011-001007-12
Details
2019-02-06
Interventional
31139 
Niacin Niacinamide Nicotinic Acids Simvastatin
Dyslipidemias Hypercholestero… Mixed Dyslipide… Primary Hyperch…
Business Reasons
Study was terminated for business reasons.
NCT01301391
Details
2019-02-06
Interventional
230 
Maleic acid
Thymoma Thymus Neoplasm… Malignant Thymo…
For the last patient still on treated nominal therapeutic use of the Milciclib was approved at INT Milano.
-
NCT01011439
2009-014338-79
Details
2019-02-06
Interventional
272 
Maleic acid
Carcinoma Thymoma Thymic Carcinom…
For the 2 last patients still on treated nominal therapeutic use of the Milciclib was approved at INT Milano.
-
NCT02533336
Details
2019-02-05
Interventional
34917 
Abamectin
Malaria
futility ground
-
NCT02393378
2014-002945-23
Details
2019-02-05
Interventional
27 
Adalimumab Folic Acid Methotrexate
Arthritis Arthritis, Rheu… Rheumatoid Arth…
Strategic decision - to understand data from psoriasis study - NCT02129777 and wait for results of formal proof of concept study - NCT02379091.
-
NCT02044510
Details
2019-02-05
Interventional
2/332 
Mirabegron
Urinary Bladder…
Slow recruitment and small observed effect size
-
NCT01115803
Details
2019-02-05
Interventional
129 
Erlotinib Hydro… Everolimus
Carcinoma Carcinoma, Non-… Carcinoma, Rena… Neoplasm Metast… Neuroendocrine … Carcinoma, Non-… Metastases, Neo… Renal Cell Carc…
Primary objective has been met; safety and pharmacokinetics have been characterized.
Study terminated early. Dose confirmation, Part B, was not initiated.
NCT01025882
Details
2019-02-05
Interventional
15 
Gemcitabine
Pancreatic Neop… Pancreatic Canc…
DSMC closed due to patient deaths
-
NCT00080119
Details
2019-02-05
Interventional
2/3
[2 Refs]
1354 
Isoniazid Sulfamethoxazol… Trimethoprim
Infections Pneumonia, Pneu… Tuberculosis HIV Infection Pneumocystis Ji…
Data Safety Monitoring Board (DSMB) recommended stopping study due to futility
DSMB recommended stopping study due to futility: "no compelling reason to enroll additional infants" or "to continue to treat participants with the blinded study medication". Week 192 analyses not done as <4% (26%) of HIVpos (HIVneg) reached wk 192
NCT03717038
2018-003187-31
Details
2019-02-04
Interventional
30 
Trifluridine
Carcinoma Colorectal Neop… Colorectal Canc… Metastatic Colo…
Study was withdrawn due to administrative reasons
-