Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02373865
Details
2019-02-27
Interventional
44 
Glimepiride Sitagliptin Pho…
Diabetes Mellit… Diabetes Mellit… Hypoglycemia Diabetes Mellit…
Premature termination due to insufficient patient recruitement..
Limitations of the study: deceleration of patient recruitment, break up of patient recruitment, descriptive reporting of patient characteristics of 4 enrolled patients (no statistically reliable results are available)
NCT00920556
Details
2019-02-27
Interventional
224 
Bortezomib
Multiple Myelom… Neoplasms, Plas…
Study terminated.24 subjects enrolled;provided adequate data for decision making.
The study of Multiple Myeloma, was terminated early due to minimal efficacy signal observed.
NCT00315913
Details
2019-02-27
Interventional
20 
Propranolol
Dystocia Dysfunctional L…
Lack of feasibility
-
NCT01168908
Details
2019-02-26
Interventional
220 
Sildenafil Citr…
Muscular Dystro… Muscular Dystro… Becker Muscular… Duchenne Muscul…
As recommended by the DSMB.
-
NCT02973399
Details
2019-02-22
Interventional
15 
Ibrutinib
Cancer
Low recruitment
-
NCT02873702
Details
2019-02-22
Interventional
337 
Dexlansoprazole Lansoprazole
Esophagitis Erosive Esophag…
Compound is not expected to change the current treatment practice or fill significant clinical need for patients in China over currently available EE agents.
-
NCT02123264
Details
2019-02-22
Interventional
328 
Zoledronic Acid
Arthritis Arthritis, Rheu…
-
-
NCT00913393
Details
2019-02-22
Interventional
246 
Antibodies, Mon…
Diabetes Mellit… Diabetes Mellit… Diabetic Nephro… Kidney Diseases Diabetic Kidney… Diabetic Nephro… Type 2 Diabetes…
Study was terminated early for business purposes and as a result of a strategic decision to shift focus to another indication.
-
NCT03361124
Details
2019-02-21
Interventional
40 
Oxytocin
Anemia Hemorrhage Uterine Inertia Blood Loss Anem… Uterine Atony W…
Investigator no longer interested in proceeding with study
-
NCT02708160
Details
2019-02-21
Interventional
20 
Fluorides
Dental Caries
Withdrawn due to business reasons
-
NCT02561832
Details
2019-02-20
Interventional
115 
Carboplatin Cyclophosphamid… Olaparib
Breast Neoplasm… Breast Cancer
This decision was based upon strategic considerations impacting the clinical development of olaparib in this indication.
Early termination leading to a small number of subjects analyzed (N=15).
NCT01195974
Details
2019-02-20
Interventional
113 
Drospirenone an…
Acquired Immuno… Communicable Di… HIV Infections Infections Infection, Huma…
In a Phase II study in HIV-infected patients there were a number of seizures, although exact causality could not be assessed phase 1 activity was terminated.
-
NCT03146403
Details
2019-02-19
Interventional
233 
Vaccines
Communicable Di… Herpes Genitali… Herpes Simplex Herpesviridae I… Infections Genital Herpes HSV-2 Infection
2017 business decision to cease GEN-003 spending.
Small numbers of enrolled subjects likely led to a lack of statistical power. After a 2017 business decision to cease GEN-003 spending, the outcome measures were reduced to 6 months of follow up, rather than the originally planned 12 months.
NCT01376310
Details
2019-02-19
Interventional
2159 
Carboplatin Docetaxel Erlotinib Hydro… Everolimus Gemcitabine Paclitaxel Pemetrexed Trametinib
Cancer
Company Decision
-
NCT02662036
Details
2019-02-18
Interventional
470 
Bupivacaine
Mammaplasty
Interim analysis showed that there was no difference between the two drugs
-
NCT00836927
Details
2019-02-18
Interventional
27 
Sirolimus
Neoplasms Advanced Cancer…
-
-
NCT02620384
Details
2019-02-15
Interventional
3147 
Metolazone
Heart Failure Acute Decompens…
Limited resources available to met accrual goal.
Recruitment ended early due to limited resources,however all protocol directed measures were completed for all enrolled. I&O was measured and recorded manually which introduces room for error.BORG assessment timing not exact due to limited resources.
NCT02409355
2014-003106-33
Details
2019-02-15
Interventional
38 
Atezolizumab Carboplatin Gemcitabine
Carcinoma, Non-… Lung Neoplasms Non-Small Cell …
The study was closed due to low patient enrollment and the Sponsor's decision to include patients with squamous NSCLC into the GO29431 study, NCT02409342.
The study was closed due to low enrollment and the Sponsor's decision to include patients with squamous NSCLC into the GO29431 study.
NCT01841307
Details
2019-02-15
Interventional
116 
Cromolyn Sodium
Gastroesophagea… Idiopathic Pulm… Pulmonary Fibro… Respiratory Asp… Lung Transplant…
Difficulty recruiting; Funding ended; interim analysis provided sufficient data for interpretation.
-
NCT01587222
Details
2019-02-15
Interventional
20 
Midodrine Octreotide
Hepatorenal Syn… Renal Insuffici… Fibrosis Renal Failure
the sponsor did not provide the treatment
-