Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02907307
Details
2019-03-08
Interventional
30 
Clotrimazole Miconazole
Candidiasis Candidiasis, Vu… Vulvovaginal Ca…
Development project stopped
-
NCT03695822
Details
2019-03-07
Interventional
40 
Mirabegron
Syndrome Urinary Bladder… Overactive Blad…
I did not pass the 2018 Ministry of Science and Technology research project subsidy, so I applied for the project to close the case.
-
NCT03060980
Details
2019-03-07
Interventional
3245 
Empagliflozin Exenatide Glimepiride
Diabetes Mellit…
Decision by Sponsor
-
NCT02857465
Details
2019-03-07
Interventional
30 
BB 1101 Dexamethasone Dexamethasone a… Dsuvia Ropivacaine Sufentanil
Labor Pain Obstetric Pain Other Complicat…
French Agency for the Safety of Health Products refusal
-
NCT01785771
Details
2019-03-07
Interventional
3-
Exenatide
Diabetes Mellit… Diabetes Mellit… Type 2 Diabetes
Decision by Sponsor
-
NCT01587261
Details
2019-03-06
Interventional
20 
Ascorbic Acid
Burns Wounds and Inju… Severe Thermal …
This potential study was held up at the level of the FDA as they wouldn't approve and IND for the dose of vitamin C we wanted to use.
-
NCT01198158
Details
2019-03-06
Interventional
377 
Antibodies Antibodies, Mon… Antineoplastic … Bevacizumab Endothelial Gro… Everolimus Immunoglobulin … Immunoglobulins
Carcinoma Carcinoma, Rena… Clear Cell Rena… Recurrent Renal… Stage III Renal… Stage IV Renal …
-
-
NCT00754923
Details
2019-03-06
Interventional
211 
Sorafenib
Carcinoma, Non-… Lung Neoplasms Lung Cancer
-
The study was discontinued, after withdrawal from the sponsor due to slow accrual. The discovery of EGFR mutations changed the scope of the trial.
NCT00365937
Details
2019-03-06
Interventional
1/219 
Adjuvants, Immu… Monatide (IMS 3…
Melanoma
New regulatories of the peptides by the pharmaceutical company (the seller)
-
NCT03172988
Details
2019-03-05
Interventional
4126 
BB 1101 Dexamethasone Dexamethasone 2… Dexamethasone a… Flurbiprofen Flurbiprofen ax…
Carcinoma, Non-… Dexamethasone Flubiprofen Axe… Long-term Effec… Surgery
Protocol violation occurred frequently during the postoperative period.
-
NCT00063934
Details
2019-03-05
Interventional
1/231 
Docetaxel Doxorubicin Lenograstim Liposomal doxor… Oblimersen
Breast Neoplasm… Breast Neoplasm… Male Breast Can… Stage IIIA Brea… Stage IIIB Brea… Stage IIIC Brea… Stage IV Breast…
-
-
NCT02846792
Details
2019-03-04
Interventional
1/25 
Nivolumab
Carcinoma, Non-… Lung Neoplasms ALK Gene Transl… EGFR Activating… ROS1 Gene Trans… Recurrent Non-S… Stage IIIB Non-… Stage IV Non-Sm…
Immunotherapy approved for NSCLC in the first line setting
Study terminated (stopped prematurely), due to immunotherapy approved for NSCLC in the first line setting. Participant flow, Baseline Characteristics and Adverse Events recorded for 5 patients treated on study.
NCT02109965
Details
2019-03-04
Interventional
412 
Dexmedetomidine Midazolam Propofol
Sepsis Toxemia Severe Sepsis
-
-
NCT02131155
Details
2019-03-01
Interventional
336 
Afatinib
Head and Neck N…
-
The study was early terminated by the sponsor along with the global companion trial 1200.131 (NCT01345669), following the recommendation from the external Data Monitoring Committee (DMC) due to futility of 1200.131, but not due to safety concern.
NCT01701323
Details
2019-03-01
Interventional
17 
Cytarabine Fludarabine Fludarabine pho…
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Leukemia … Acute Myeloid L…
-
-
NCT02738905
Details
2019-02-28
Interventional
10 
Rifaximin
Kidney Diseases Kidney Failure,… End Stage Renal…
insufficient support
-
NCT02269085
Details
2019-02-28
Interventional
18 
Ibrutinib
Lymphoma Lymphoma, Mantl…
slow accrual
-
NCT01163084
Details
2019-02-28
Interventional
1/210 
Goserelin Leuprolide
Adenocarcinoma Prostatic Neopl… Prostate Adenoc… Stage IIA Prost… Stage IIB Prost…
-
-
NCT02575365
Details
2019-02-27
Interventional
44 
Fingolimod Hydr…
Nerve Degenerat… Brain Volume Lo… Cognition
The trial was terminated due to low enrollment.
The trial was terminated due to low enrollment.
NCT02444793
Details
2019-02-27
Interventional
124 
Mogamulizumab
Neoplasms Advanced/Metast…
The study was terminated due to marginal efficacy and change in sponsor prioritization. The combination had a manageable safety profile.
The study was terminated due to marginal efficacy and change in sponsor prioritization. No participants were enrolled in the dose-expansion portion.