Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02873351
Details
2019-04-05
Interventional
20 
Carbidopa Carbidopa, levo… Levodopa
Macular Degener… Age-related Mac…
Decided to do studies in patients with AMD
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NCT02030405
Details
2019-04-05
Interventional
24 
Ixazomib Proteasome Inhi…
Leukemia Leukemia, Eryth… Leukemia, Megak… Leukemia, Monoc… Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Adult Acute Meg… Adult Acute Min… Adult Acute Mon… Adult Acute Mon… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Erythrole… Adult Pure Eryt… Recurrent Adult…
Regulatory
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NCT01485055
Details
2019-04-05
Interventional
211 
Basiliximab Infliximab
Graft vs Host D… Acute GVH Disea… Graft Versus Ho… Steroid Refract…
Sponsor withdrew support
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NCT03175172
Details
2019-04-04
Interventional
210 
Pembrolizumab
Mesothelioma Mesothelioma, M… Malignant Pleur…
Study was stopped due to low enrollment and lack of clinical activity.
Study was terminated early and included a small number of subjects, and insufficient data were available to evaluate the clinical activity of the study treatment. Due to low enrollment, some protocol-specified outcome measures were not evaluated.
NCT03122548
Details
2019-04-04
Interventional
25 
Pembrolizumab
Adenocarcinoma Esophageal Neop… Esophageal Aden… Gastric Adenoca… Gastroesophagea…
Low enrollment and lack of clinical activity in other CRS-207 studies.
Study was terminated early and included a small number of subjects, and insufficient data were available to evaluate the clinical activity of the study treatment. Due to low enrollment, some protocol-specified outcome measures were not evaluated.
NCT03066817
Details
2019-04-04
Interventional
1/2-
Ergocalciferols Vitamin D
Multiple Trauma Musculoskeletal… Vitamin D Defic… Orthopedic Diso… Polytrauma
Waiting for annual IRB progress report to be reviewed and approved
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NCT02575807
Details
2019-04-04
Interventional
1/235 
Pembrolizumab
Ovarian Neoplas… Peritoneal Neop… Platinum-resist… Platinum-resist… Platinum-resist…
Study was stopped due to low enrollment and lack of clinical activity.
Study was terminated early and included a small number of subjects, and insufficient data were available to evaluate the clinical activity of the study treatment. Due to low enrollment, some protocol-specified outcome measures were not evaluated.
NCT02395692
Details
2019-04-04
Interventional
220 
Temozolomide
Glioblastoma Adult Brain Gli…
Pre-specified response criteria not met to proceed to next stage of study.
n for this study 31 subjects w/ a 2 stage design. 19 subjects were treated in stage one with TRC102 and TMZ in recurrent GBM. If no more than 2 responses were observed among the initial 19 patients the study would be terminated and declared negative
NCT01084369
Details
2019-04-04
Interventional
422 
Methyltestoster… Testosterone Testosterone 17… Testosterone en… Testosterone un… Vardenafil Dihy…
Diabetes Mellit… Hypogonadism Type 2 Diabetes
Withdrawal of sponsorship
-
NCT03892161
Details
2019-04-03
Interventional
117 
Darunavir Rifampin Ritonavir
HIV Infections
Risks to participation
-
NCT03384524
Details
2019-04-01
Interventional
1/20 
Bromocriptine Metoprolol Tamsulosin
Macular Edema Diabetic Macula…
withdrawn during planning stages
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NCT02037412
Details
2019-03-29
Interventional
4148 
Clopidogrel Ticagrelor
Acute Coronary … Angina, Unstabl… Infarction Myocardial Infa… Syndrome Acute Myocardia… Unstable Angina…
The patient registration was not successful.
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NCT02992132
2016-001127-32
Details
2019-03-28
Interventional
2111 
Pimavanserin
Aggression Alzheimer Disea… Psychomotor Agi… Agitation and A…
-
The original study (n=432) was powered to detect a treatment effect on CMAI, however recruitment was discontinued early for business reasons and amended accordingly The final study (n=111) was no longer adequately powered to detect a treatment effect
NCT02242084
Details
2019-03-28
Interventional
212 
Tissue Plasmino…
Intestinal Dise… Urinary Retenti… Damage in the A… Motor Weakness … Temperature and… Urinary Retenti…
-
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NCT00979641
2008-003527-24
Details
2019-03-28
Interventional
265 
Docetaxel
Breast Neoplasm… Neoplasms
Participants are no longer being examined. The results are published 2016 Anticancer Research 36: 6431-6438
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NCT02624661
Details
2019-03-27
Interventional
1/21 
Glycerol
Ganglion Cysts Headache Headache Disord… Neuralgia Trigeminal Neur…
technical problems
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NCT01569152
2012-000439-17
Details
2019-03-27
Interventional
282 
Methotrexate
Arthritis Arthritis, Rheu… Rheumatoid Arth…
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This study was terminated early (12 September 2013) based on preliminary analysis of data. The results of this study need to be interpreted with caution given the small sample size (82 participants) resulting from the early termination of the study.
NCT03856112
Details
2019-03-26
Interventional
1/20 
BB 1101 Dexamethasone Dexamethasone a… Glycine Ichthammol Ixazomib Venetoclax
Multiple Myelom… Neoplasms, Plas… Recurrent Plasm… Refractory Plas… t(11;14) Negati…
Per CTEP, Martha Khrum this study is withdrawn. Changing status to update CT.gov
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NCT02568046
2015-003047-19
Details
2019-03-26
Interventional
1/210 
Fluorouracil Irinotecan Leucovorin
Colorectal Neop… Metastatic Colo…
Discontinued development of Sym004 in combination with FOLFIRI
The trial was terminated as development of Sym004 in combination with FOLFIRI was discontinued. The primary objective changed to assess the safety of the treatment combination; collection of data for secondary and exploratory objectives was omitted.
NCT02372578
Details
2019-03-26
Interventional
2115 
Pregabalin
Diabetic Neurop… Pain Peripheral Nerv… Painful Diabeti…
The study was terminated due to futility analysis.
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